volume 9, issue 2, P315-339 2017
DOI: 10.18632/aging.101174
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Irina G. Shabalina, Mikhail Yu. Vyssokikh, Natalia Gibanova, Robert I. Csikasz, Daniel Edgar, Anne Hallden-Waldemarson, Zinaida Rozhdestvenskaya, Lora E. Bakeeva, Valeria B. Vays, Antonina V. Pustovidko, Maxim V. Skulachev, Barbara Cannon, Vladimir P. Skulachev, Jan Nedergaard et al.

Abstract: MtDNA mutator mice exhibit marked features of premature aging. We find that these mice treated from age of ≈100 days with the mitochondria-targeted antioxidant SkQ1 showed a delayed appearance of traits of aging such as kyphosis, alopecia, lowering of body temperature, body weight loss, as well as ameliorated heart, kidney and liver pathologies. These effects of SkQ1 are suggested to be related to an alleviation of the effects of an enhanced reactive oxygen species (ROS) level in mtDNA mutator mice: the increa…

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