2013
DOI: 10.1002/jbmr.1996
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Abstract: More accurate techniques to estimate fracture risk could help reduce the burden of fractures in postmenopausal women. Although micro-finite element (µFE) simulations allow a direct assessment of bone mechanical performance, in this first clinical study, we investigated whether the additional information obtained using geometrically and materially nonlinear µFE simulations allows a better discrimination between fracture cases and controls. We used patient data and high-resolution peripheral quantitative compute… Show more

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Cited by 44 publications
(14 citation statements)
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References 34 publications
(61 reference statements)
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“…These procedures would further benefit from more rigorous multicenter training procedures and automation of scan positioning and image quality control. Moreover, other microstructural and biomechanical parameters, such as cortical porosity, trabecular topology, stiffness, or failure load that have been reported to be associated with fracture, (6,(40)(41)(42)(43)(44) but were not evaluated in this study, might also be of interest to discriminate women with and without fracture.…”
Section: Discussionmentioning
confidence: 99%
“…These procedures would further benefit from more rigorous multicenter training procedures and automation of scan positioning and image quality control. Moreover, other microstructural and biomechanical parameters, such as cortical porosity, trabecular topology, stiffness, or failure load that have been reported to be associated with fracture, (6,(40)(41)(42)(43)(44) but were not evaluated in this study, might also be of interest to discriminate women with and without fracture.…”
Section: Discussionmentioning
confidence: 99%
“…High-resolution peripheral quantitative computed tomography (HR-pQCT) is increasingly used [1] to assess bone quality [2,3], to investigate age-, sex-, and race-related differences [4,5], to evaluate bone diseases and monitor drug therapies [69], and to assess fracture risk [10,11]. HR-pQCT allows the acquisition of in vivo high-resolution images (isotropic voxel size 82μm, stack length = 9.02mm) of the distal radius and distal tibia with low radiation dose (3μSv).…”
Section: Introductionmentioning
confidence: 99%
“…It has been demonstrated that such analyses can better predict bone strength than linear elastic analyses (Macneil and Boyd, 2008a;Christen et al, 2013), although the improvements usually are only modest. Such analyses do have the advantage, however, of providing more parameters to quantify the failure behavior, such as the amount of energy absorbed at yielding .…”
Section: Micro-fe Modelingmentioning
confidence: 98%