Improved Efficacy of 10-Day Sequential Treatment for Helicobacter pylori Eradication in Children: A Randomized Trial

Francavilla, Ruggiero; Lionetti, Elena; Castellaneta, Stefania; Magistà, Anna Maria; Boscarelli, Giuseppe; Piscitelli, Domenico; Amoruso, A.; Leo, Alfredo Di; Miniello, Vito Leonardo; Francavilla, A.; Cavallo, Luciano; Ierardi, Enzo

doi:10.1053/j.gastro.2005.09.007

Cited by 133 publications

(118 citation statements)

References 30 publications

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“…This regimen, compared with the conventional triple therapy, improved eradication rates by 18% and 22%, respectively, was well tolerated, safe and had good compliance in both adults and children. [12,13] Local data on eradication rates are not available but anecdotal evidence suggests that there are increasing failure rates to the standard triple therapy regimens.…”

mentioning

confidence: 99%

Effectiveness of sequential v. standard triple therapy for treatment of Helicobacter pylori infection in children in Nairobi, Kenya

et al. 2013

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Background. Once the diagnosis of Helicobacter pylori is confirmed, treatment requires at least two antibiotics and an acid inhibitor for a minimum of seven days. Unfortunately, treatment failures are being frequently reported. Treatment regimens that include sequential administration of antibiotics with acid inhibitors have been developed to try and increase the rate of eradication. Objective. To determine the effectiveness of a novel 10-day sequential therapy compared with the standard 10-day triple therapy for treatment of H. pylori infection in children. Methods. A double-blinded, randomised, controlled trial was conducted. Children under the age of 16 years with recurrent abdominal pain associated with dyspepsia and diagnosed with H. pylori by histology were randomly allocated either to a 10-day sequential treatment regimen or to a 10-day conventional triple therapy. Analysis of the outcome of this study was based on clinical improvement and confirmed H. pylori eradication based on stool H. pylori antigen detection and/or repeat endoscopy. Results. Of the 71 patients included in the analysis, 45 (63.4%) were given the 10-day conventional treatment while 26 (36.6%) received the 10-day sequential treatment. There was no difference in clinical improvement after treatment in the two therapies. However, there was a significant difference in the eradication of H. pylori between the conventional v. sequential regimens (48.8% v. 84.6%, respectively; p=0.02, odds ratio 0.19). Conclusion. The sequential treatment had a significantly higher H. pylori eradication rate than the conventional treatment.

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Effectiveness of sequential v. standard triple therapy for treatment of Helicobacter pylori infection in children in Nairobi, Kenya

et al. 2013

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“…There are a few studies performed in children investigating the role of sequential therapy. Francavilla et al (10) demonstrated that the eradication rate of H. pylori infection was significantly higher in sequential therapy (97,3%) versus standard triple therapy (75,7%) in 87 children. Lionetti et al (11) found an overall eradication rate of 82,5% in 40 children.…”

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confidence: 99%

Ornidazole-based sequential therapy is not effective in Helicobacter pylori eradication in children

Baysoy

In²,

Uslu³

et al. 2013

Turk J Gastroenterol

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“…Wysoką skuteczność i dobrą tolerancję terapii sekwencyjnej w porównaniu z klasyczną trójlekową z CL potwierdzają również wyniki badań Francavilla i wsp. [33] oraz de Francesco i wsp., także w odniesieniu do wysoce opornych na CL szczepów z mutacją w pozycji A2143G podjednostki 23S RNA H. pylori [34].…”

Section: Terapia Sekwencyjnaunclassified

Treatment prospects of Helicobacter pylori infection

Ksiądzyna¹,

Szandruk²,

Szeląg³

2012

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Improved Efficacy of 10-Day Sequential Treatment for Helicobacter pylori Eradication in Children: A Randomized Trial

Cited by 133 publications

References 30 publications

Effectiveness of sequential v. standard triple therapy for treatment of Helicobacter pylori infection in children in Nairobi, Kenya

Effectiveness of sequential v. standard triple therapy for treatment of Helicobacter pylori infection in children in Nairobi, Kenya

Ornidazole-based sequential therapy is not effective in Helicobacter pylori eradication in children

Treatment prospects of Helicobacter pylori infection

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