Improved detection limits using a hand-held optical imager with coregistration capabilities

Three simple and low-cost configurations of handheld scanning probes for optical coherence tomography have been developed. Their design and testing for dentistry applications are presented. The first two configurations were built exclusively from available off-the-shelf optomechanical components, which, to the best of our knowledge, are the first designs of this type. The third configuration includes these components in an optimized and ergonomic probe. All the designs are presented in detail to allow for their duplication in any laboratory with a minimum effort, for applications that range from educational to high-end clinical investigations. Requirements that have to be fulfilled to achieve configurations which are reliable, ergonomic—for clinical environments, and easy to build are presented. While a range of applications is possible for the prototypes developed, in this study the handheld probes are tested ex vivo with a spectral domain optical coherence tomography system built in-house, for dental constructs. A previous testing with a swept source optical coherence tomography system has also been performed both in vivo and ex vivo for ear, nose, and throat—in a medical environment. The applications use the capability of optical coherence tomography to achieve real-time, high-resolution, non-contact, and non-destructive interferometric investigations with micrometer resolutions and millimeter penetration depth inside the sample. In this study, testing the quality of the material of one of the most used types of dental prosthesis, metalo-ceramic is thus demonstrated.

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“…Optical designs 22 as well as improvements in the instruments and the techniques have been approached. 23 – 26 …”

Section: Introductionmentioning

confidence: 99%

Design and testing of prototype handheld scanning probes for optical coherence tomography

Demian

Duma

Sinescu

et al. 2014

Proc Inst Mech Eng H

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“…The positional tracking capability allowed registration of the optical images with respect to the imaged tissue geometry, and hence provided 3D volumetric analysis as well (34). Extensive tissue phantom studies were performed to demonstrate 3D tomographic imaging capabilities of the imager (30, 35) as well as improved target depth detection (36). In vivo 3D tomographic breast imaging studies (on healthy subjects containing superficially placed tumor-like targets) were demonstrated using the hand-held optical imager (33).…”

Section: Introductionmentioning

confidence: 99%

Noninvasive surface imaging of breast cancer in humans using a hand-held optical imager

Erickson-Bhatt

Roman

Gonzalez

et al. 2015

Biomed. Phys. Eng. Express

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X-ray mammography, the current gold standard for breast cancer detection, has a 20% false-negative rate (cancer is undetected) and increases in younger women with denser breast tissue. Diffuse optical imaging (DOI) is a safe (nonionizing), and relatively inexpensive method for noninvasive imaging of breast cancer in human subjects (including dense breast tissues) by providing physiological information (e.g. oxy- and deoxy- hemoglobin concentration). At the Optical Imaging Laboratory, a hand-held optical imager has been developed which employs a breast contourable probe head to perform simultaneous illumination and detection of large surfaces towards near real-time imaging of human breast cancer. Gen-1 and gen-2 versions of the handheld optical imager have been developed and previously demonstrated imaging in tissue phantoms and healthy human subjects. Herein, the hand-held optical imagers are applied towards in vivo imaging of breast cancer subjects in an attempt to determine the ability of the imager to detect breast tumors. Five female human subjects (ages 51–74) diagnosed with breast cancer were imaged with the gen-1 optical imager prior to surgical intervention. One of the subjects was also imaged with the gen-2 optical imager. Both imagers use 785 nm laser diode sources and ICCD camera detectors to generate 2D surfaces maps of total hemoglobin absorption. The subjects lay in supine position and images were collected at various locations on both the ipsilateral (tumor-containing) and contralateral (non-tumor containing) breasts. The optical images (2D surface maps of optical absorption due to total hemoglobin concentration) show regions of higher intensity at the tumor location, which is indicative of increased vasculature and higher blood content due to the presence of the tumor. Additionally, a preliminary result indicates the potential to image lymphatic spread. This study demonstrates the potential of the hand-held optical devices to noninvasively image breast cancer in human subjects.

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“…Some authors have suggested diffuse optical tomography for hematoma detection; however, this approach is costly, requires large instrumentation, and is not as available as a handheld, real-time solution on the full adult head. Another recent approach uses 3D localization to register multiple images collected with a handheld device [ 20 ]; this is a similar idea to that presented here, but is still effectively concerned with using static imaging. Other, so called moving, devices do exist (such as [ 21 ]), but they are also designed to make static measurements at discrete locations, as opposed to taking measurements as the device itself tracks.…”

Section: Introductionmentioning

confidence: 99%

A hematoma detector—a practical application of instrumental motion as signal in near infra-red imaging

Riley

Amyot

Pohida

et al. 2011

Biomed. Opt. Express

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In this paper we discuss results based on using instrumental motion as a signal rather than treating it as noise in Near Infra-Red (NIR) imaging. As a practical application to demonstrate this approach we show the design of a novel NIR hematoma detection device. The proposed device is based on a simplified single source configuration with a dual separation detector array and uses motion as a signal for detecting changes in blood volume in the dural regions of the head. The rapid triage of hematomas in the emergency room will lead to improved use of more sophisticated/expensive imaging facilities such as CT/MRI units. We present simulation results demonstrating the viability of such a device and initial phantom results from a proof of principle device. The results demonstrate excellent localization of inclusions as well as good quantitative comparisons.

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Improved detection limits using a hand-held optical imager with coregistration capabilities

Cited by 9 publications

References 12 publications

Design and testing of prototype handheld scanning probes for optical coherence tomography

Design and testing of prototype handheld scanning probes for optical coherence tomography

Noninvasive surface imaging of breast cancer in humans using a hand-held optical imager

A hematoma detector—a practical application of instrumental motion as signal in near infra-red imaging

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