Improved collagen bilayer dressing for the controlled release of drugs

Abstract

A novel bilayer dressing has been developed from bovine succinylated collagen. The dressing contains an antibiotic, Ciprofloxacin, for both immediate and time-regulated release for controlling the infection, as the infected open wounds need special care. The dressing consists of a sponge and a film, both prepared from succinylated bovine collagen. The sponge has a smooth surface on one side; its rough surface on the other side forms the bilayer system with the film. Both sponge and film act as an anionic reservoir to hold the cationic Ciprofloxacin. The drug, after dispersing in poly (N-vinyl-2-pyrrolidione) (PVP) solution is allowed to spread in the bilayer system by diffusion. The drug stays in the bilayer system because of ionic binding, but starts releasing when comes in contact with the wound. Release of the drug is immediate, but it is regulated by ionic binding between the drug and succinylated collagen. The wound exudates, and there is a polarity-controlled release of the drug from the bilayer system. The PVP and bilayer system permits only time-regulated release, and the system lasts up to 5 days with therapeutically sufficient drug availability.

Antibiotic-eluting bioresorbable composite fibers for wound healing applications: Microstructure, drug delivery and mechanical properties

“…Vascular grafts sealed with albumin and gelatin have been shown to promote such interactions and therefore demonstrate a reduced burst release of antibiotics compared to uncoated grafts [11,12]. A wound dressing based on succinylated collagen, which behaves as an anion after swelling, has been shown to delay the release of the cationic drug ciprofloxacin via ionic interactions [17].…”

“…Hence, characteristic healing has been reported to take 3-7 weeks [14]. Common strategies that have been described in an attempt to overcome the problem of rapid drug release include the entrapment of the hydrophilic drug within a hydrophobic substance as a means to delay water penetration and outward drug diffusion [15,16], or enhancement of drug bonding to the carrying matrix [11,12,17]. The latter can be achieved either by selecting or modifying a matrix material to support the formation of covalent bonds, Van der Waals dispersion forces, hydrogen bonds, or ionic interactions between the drug and the matrix.…”

Physicochemical Properties of Succinylated Calfskin Pepsin-Solubilized Collagen

“…In addition, SPSC with increased negative charges acted as an anionic reservoir to hold the cationic drugs by ionic binding, which permitted only time-regulated release of drugs. 9) Meanwhile, the relative viscosity and intrinsic viscosity of SPSC became about 1.6-fold and 1.8-fold higher than those of PSC respectively, also because of the increase in negative charges of PSC and the hydrodynamic volume of the modified collagen.…”

“…Proper chemical modification can be a good choice for overcoming this limitation of PSC. Succinylation has been widely used in soy protein modification in food industry 3,4) and in collagen modification in the biomedical field, such as time-regulated released drugs, 5) vascular prostheses, 6) and biomaterial carriers with a porous structure. 7) In order to apply succinylated collagen much more efficiently, it is of importance to study its physicochemical properties.…”

Biodegradable soy wound dressings with controlled release of antibiotics: Results from a guinea pig burn model

“…The hydrophilic nature of soy protein enables relatively rapid water intake, leading to full swelling of the matrix within a few hours of immersion. Unfavorable more rapid drug release rates have been reported in the literature for other antibioticeluting systems [33]. Controlling the release of antibiotics from these systems is challenging due to the hydrophilic nature of both the drug and the host polymer.…”