Improved biopharmaceutical attributes of lumefantrine using choline mimicking drug delivery system: preclinical investigation on NK-65 <i>P.berghei</i> murine model

Kaur, Ripandeep; Gorki, Varun; Katare, Om Prakash; Dhingra, Neelima; Chauhan, Monika; Kaur, Ranjot; Nirmalan, Niroshini; Singh, Bhupinder

doi:10.1080/17425247.2021.1946512

Cited by 4 publications

(1 citation statement)

References 71 publications

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“…The improved solubility of lumefantrine (LUM) in an aqueous medium by using lumefantrine phospholipid complex (LMF-PC) enhanced antimalarial activity in a murine model ( Kaur et al, 2021 ). The matrices of microneedle (MN) containing ART (MN-ART) and LUM (MN-LUM) in nanosuspensions, applied as intradermal devices, showed increased solubility of drugs and potential as an alternative treatment for malaria in endemic regions with scarce resources ( Volpe-Zanutto et al, 2021 ).…”

Section: Resistance To Antimalarialsmentioning

confidence: 99%

Potential of nanoformulations in malaria treatment

Chaves

Moraes²,

Ferrarini³

et al. 2022

Front. Pharmacol.

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Malaria is caused by the protozoan Plasmodium sp and affects millions of people worldwide. Its clinical form ranges from asymptomatic to potentially fatal and severe. Current treatments include single drugs such as chloroquine, lumefantrine, primaquine, or in combination with artemisinin or its derivatives. Resistance to antimalarial drugs has increased; therefore, there is an urgent need to diversify therapeutic approaches. The disease cycle is influenced by biological, social, and anthropological factors. This longevity and complexity contributes to the records of drug resistance, where further studies and proposals for new therapeutic formulations are needed for successful treatment of malaria. Nanotechnology is promising for drug development. Preclinical formulations with antimalarial agents have shown positive results, but only a few have progressed to clinical phase. Therefore, studies focusing on the development and evaluation of antimalarial formulations should be encouraged because of their enormous therapeutic potential.

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Section: Resistance To Antimalarialsmentioning

confidence: 99%