Imprint Cytology of Core Needle Biopsy Specimens of Breast Lesions

Albert, Ute‐Susann; Duda, Volker; Hadji, P.; Goerke, Kay; Hild, F.; Bock, Karin; Ramaswamy, A.; Schulz, K.-D.

doi:10.1159/000326226

Cited by 31 publications

(11 citation statements)

References 17 publications

(12 reference statements)

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“…The following measures were satisfactory: absolute sensitivity, complete sensitivity, inadequate rate with carcinoma and suspicious rate. Sensitivity and specificity agree with other authors 9 10 29 30. Among suspicious examinations, 87.5% were reported to be malignant by surgical biopsies, with one report of a chronic inflammatory process, demonstrating elevated concordance with the histological diagnosis of malignancy.…”

Section: Discussionsupporting

confidence: 89%

“…The literature shows a false positive rate ranging from 0% to 5%, typically occurring with the same type of lesions that lead to false positives in FNA 29 31. The false negative rate was also unsatisfactory in relation to values in the literature; this could be associated with lack of experience in breast cytology, or the presence of hypocellular lesions and artifacts 29 30 32…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the clinical efficacy of minimally invasive procedures for breast cancer screening at a teaching hospital

et al. 2011

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Evaluation of the clinical efficacy of minimally invasive procedures for breast cancer screening at a teaching hospital

et al. 2011

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“…But on histopathology a diagnosis tubular carcinoma was made which was the only false negative case in the present study. 12 This study revealed a diagnostic accuracy of 97% on imprint cytology, which was comparable to the studies done by Rosa et al, 6 Vineti et al, 7 Scucchi et al, 8 Albert et al 9 and Khudier et al 2 However it was much higher than that reported by Creager et al 10 The specificity of imprint cytology in the present study was 96.1% which was lesser than that reported by Scuchhi et al, 8 Khudier et al, 2 Rosa et al 6 and Veneti et al 7 but it was higher than the study done by Creager et al 10 and Albert et al 9 In the present study sensitivity of imprint cytology was 98% which was comparable to the study by Rosa et al, 6 Vineti et al, 7 Scucchi et al, 8 Albert et al 9 and Khudier et al 2 But it was much higher than that reported by Creageret al 10 To conclude, the imprint method allows cytological techniques to be used for the examination of individual cells yet preserves to some extent the histological pattern of the imprinted tissue. Differentiating between benign and malignant lesions prior to or during surgery helps the surgeon to decide on the extent of surgery.…”

Section: Invasive Ductal Carcinomasupporting

confidence: 79%

The Diagnostic Accuracy of Imprint Cytology in Breast Lesions

Shashidhar¹,

Ahmed²,

Umaru³

2015

jemds

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BACKGROUND:The imprint cytology is one of the rapid diagnostic tools in the field of diagnostic pathology. This method not only helps us to examine the individual cells but also aids in analyzing the patterns of particular lesion. Differentiating between benign and malignant lesions prior to or during surgery, helps the surgeon to decide on the extent of surgery. AIMS: The present study was conducted to know the accuracy of intraoperative imprint smears and to compare the results with that of histopathological sections in all breast tumors. MATERIALS AND METHODS: This was a descriptive study on 100 cases of breast lesions comprising of inflammatory, benign & malignant. Results were compared with histopathology. STATISTICAL ANALYSIS USED: Sensitivity, specificity, positive predictive value and negative predictive value. RESULTS: Out of 100 cases, 50 cases were diagnosed as benign and 50 cases as malignant lesions on imprint smear. Fibroadenoma (26%) was the most common benign lesion and invasive ductal carcinoma (38%) was the most common malignant lesion. The sensitivity and specificity of imprint cytology were 98% and 96.1% respectively. 96% PPV, 98% NPV and 97% overall diagnostic accuracy was observed for imprint cytology in the present study. CONCLUSIONS: Imprint cytology is a simple, accurate, rapid & cost effective diagnostic tool used intra operatively, where in facilities for frozen sections are not available.

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“…The role of outpatient cytologic and histologic diagnosis in patients presenting with a palpable breast lump is now well established. Both fine‐needle aspiration cytology (FNAC) and percutaneous core biopsy have a specificity approaching 100% in the presence of carcinoma, but their sensitivities range between 80% and 97% (1–5). The overall sensitivity may be increased if both tests are combined, but it is not known how many core biopsies should be taken to maximize the sensitivity.…”

mentioning

confidence: 99%

A Prospective Study of the Use of Fine-Needle Aspiration Cytology and Core Biopsy in the Diagnosis of Breast Cancer

et al. 2003

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A prospective study was carried out on 143 consecutive patients with palpable lumps larger than 2 cm in size which were clinically suspicious of carcinoma. One hundred and five lumps proved to be malignant and 38 were benign. Of the 105 patients with malignancy, confirmation was made in 95 by fine-needle aspiration cytology (FNAC) with a sensitivity of 90.4% and 100 by core biopsy with a sensitivity of 95.2%. The sensitivity of core biopsies increased with the number of cores taken (one core, 76.2%; two cores, 80.9%, three cores, 89.2%; four cores, 95.2%). The combined sensitivity of FNAC and core biopsies was 100%, and so are complementary in the accurate diagnosis of breast cancer. Patients presenting to the breast clinic with a solid suspicious breast lump larger than 2 cm can benefit from FNAC and a minimum of four core biopsies to improve diagnosis.

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Imprint Cytology of Core Needle Biopsy Specimens of Breast Lesions

Cited by 31 publications

References 17 publications

Evaluation of the clinical efficacy of minimally invasive procedures for breast cancer screening at a teaching hospital

Evaluation of the clinical efficacy of minimally invasive procedures for breast cancer screening at a teaching hospital

The Diagnostic Accuracy of Imprint Cytology in Breast Lesions

A Prospective Study of the Use of Fine-Needle Aspiration Cytology and Core Biopsy in the Diagnosis of Breast Cancer

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