Important clinical and laboratory correlates of glomerular filtration rate in sickle cell anemia

Madu, AJ; Ubesie, Agozie C; Ocheni, S; Chinawa, JM; Madu, KA; Ibegbulam, Obike; Nlemadim, C; Eze, Alozie

doi:10.4103/1119-3077.154220

Cited by 5 publications

(8 citation statements)

References 9 publications

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“…This study examined the renal function of HbSS children in a steady state in a tertiary health facility. The mean eGFR of 146:5 ± 31:1 ml/min/1.73 m 2 in HbSS subjects is comparable to findings by Madu et al [17] (150 ± 74:8 ml/min/1.73 m 2 ) in Enugu South-East Nigeria, Abhulimhen-Iyoha et al [18] (148:96 ± 23:2 ml/min/1.73 m 2 ) in Benin City South-South Nigeria, and Bodas et al [4] (140 ml/min/1.73 m 2 ) in the USA. The mean eGFR in HbSS subjects in this study was significantly higher than that of age-and sex-matched HbAA subjects (128:7 ± 18:5 ml/min/1.73 m 2 ).…”

Section: Discussionsupporting

confidence: 88%

“…In this study, a weak positive correlation was found between eGFR and frequency of hospitalized past painful crisis. Similar to the index study, Bodas et al [4] and Madu et al [17] did not find any statistically significant correlation between eGFR and frequency of past painful crisis in their study. This may be due to few past history of painful crisis obtained from the subjects in this study.…”

Section: Discussionsupporting

confidence: 72%

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Sickle Cell Nephropathy and Associated Factors among Asymptomatic Children with Sickle Cell Anaemia

Nnaji

Ogoke²,

Okafor

et al. 2020

International Journal of Pediatrics

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Background. Sickle cell nephropathy (SCN) is a serious complication of sickle cell anaemia (SCA) with asymptomatic onset in childhood and possible progression to chronic kidney disease (CKD). In Southeast Nigeria, few studies have evaluated renal function in paediatric SCA patients for early detection of renal impairment and early intervention to reduce morbidity and mortality. Therefore, this study evaluated the renal function of paediatric SCA patients in a steady state based on glomerular filtration rate and urinalysis findings (proteinuria and haematuria). Methods. A cross-sectional study of consecutively recruited sixty haemoglobin SS (HbSS) children in a steady state and sixty age- and sex-matched haemoglobin AA (HbAA) controls aged 2–18 years was done. Renal function of HbSS subjects was evaluated using estimated glomerular filtration rate (eGFR) which was compared with healthy HbAA subjects. The prevalence of significant proteinuria and haematuria, its association with eGFR, and the effect of past sickle cell crisis (in the preceding 24 months) on renal function were also evaluated. Results. Mean eGFR was significantly higher in HbSS subjects than in the HbAA subjects (p=0.001) and decreased with age. Significant proteinuria and haematuria were more prevalent in the HbSS group (3.4% and 6.7%, respectively) compared to the HbAA subjects (0% and 0%, respectively) (p=0.496 and 0.119, respectively). No significant association was observed between eGFR and proteinuria (p=1.000) or haematuria (p=1.000). There was a positive correlation between eGFR and frequency of past painful crisis that required hospitalization (r=0.138, p=0.295) and between eGFR and frequency of blood transfusion (r=0.679, p≤0.001). Conclusions. Asymptomatic paediatric HbSS (SCA) patients had higher mean eGFR indicating an increased risk of nephropathy. There was no association between eGFR and proteinuria or haematuria. Frequent sickle cell crises especially one requiring transfusion were positively correlated with hyperfiltration.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 72%

Sickle Cell Nephropathy and Associated Factors among Asymptomatic Children with Sickle Cell Anaemia

Nnaji

Ogoke²,

Okafor

et al. 2020

International Journal of Pediatrics

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Section: Clinical Presentationsmentioning

confidence: 99%

“…The risk factors for leg ulceration are being a man, younger age (<20 years), low level of fetal hemoglobin, a hemoglobin level less than 6 g/dL, certain HLA types, and antithrombin deficiency. 8 Recently vasculopathic abnormalities involving abnormal vascular tone and activated, adhesive endothelium have been recognized as a contributor to end organ damage in patients with SCD. 9 Vasculopathy of SCD has been implicated in the development of pulmonary hypertension, stroke, leg ulceration, and priapism linked to hemolytic severity.…”

Section: Clinical Presentationsmentioning

confidence: 99%

Hemoglobinopathies and Leg Ulcers

Alavi

Kirsner

2015

The International Journal of Lower Extremity Wounds

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Major hemoglobinopathies, including sickle cell anemia, are becoming a global health issue. Leg ulcers are the most common cutaneous manifestation of sickle cell disease and an important contributor to morbidity burden in this population. Leg ulcers following sickling disorders are extremely painful, and hard to heal. The clinical evidence for the optimal management of these ulcers is limited. Treating the cause and the strategies to prevent sickling are the mainstay of treatment. The basic principles of wound bed preparation and compression therapy is beneficial in these patients.

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“…On the other hand, this study does not present any parameter related to kidney function, which provides the missing information of whether AST is related or not with SN 25 . However, Madu et al correlated AST levels and proteinuria, without statistical significance, which also indicates a poor correlation between this predictor and kidney injury 26 .…”

mentioning

confidence: 99%

Predictors associated with sickle cell nephropathy: a systematic review

Maurício

Ribeiro

Santos

et al. 2021

Rev. Assoc. Med. Bras.

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INTRODUCTION: Sickle cell anemia affects more than 30 million people worldwide. Chronic kidney disease develops in 40% of individuals. The death rate of patients with sickle nephropathy is still high, with little known predictors related to its development. To answer the question "What predictors are associated with the onset of chronic kidney disease in patients with sickle cell anemia?", this article seeks to contribute to a better understanding of sickle nephropathy, making possible a new look at the sickle cell anemia and its kidney complications. METHODS:A systematic review was developed, using the PRISMA recommendation, for cohort studies on predictors related to the outcome of sickle nephropathy in patients with sickle cell anemia. RESULTS:Initially 321 studies were identified in Pubmed, of which six were selected to compose this systematic review. Lower hemoglobin levels, increased ages and albuminuria were the most pointed predictors associated with chronic kidney disease. CONCLUSION:The main predictors associated with the development of chronic kidney disease in individuals with sickle cell anemia were lower hemoglobin levels, increased ages, and albuminuria. New studies evaluating predictors for the development of chronic kidney disease in sickle cell anemia are needed to better understand its installation and prevent its progression.

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Important clinical and laboratory correlates of glomerular filtration rate in sickle cell anemia

Abstract: High serum direct bilirubin and ALP are associated with a deteriorating eGFR_MDRD. Other clinical and laboratory indicators of disease severity in SCD do not show the relationship with the GFR. MDRD_GFR estimation seemed to be a more appropriate method of estimating GFR in SCD.

Cited by 5 publications

References 9 publications

Sickle Cell Nephropathy and Associated Factors among Asymptomatic Children with Sickle Cell Anaemia

Sickle Cell Nephropathy and Associated Factors among Asymptomatic Children with Sickle Cell Anaemia

Hemoglobinopathies and Leg Ulcers

Predictors associated with sickle cell nephropathy: a systematic review

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