Importância dos testes sorológicos de triagem e confirmatórios na detecção de doadores de sangue infectados pelo vírus da hepatite C

Garcia, Fernanda Bernadelli; Gomide, Geisa Peres; Pereira, Gilberto A.; Moraes-Souza, Hélio

doi:10.1590/s1516-84842008000300011

Cited by 9 publications

(11 citation statements)

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“…The total length of sample collection was seven months. After selection, the participants underwent the following steps: a) approach, called the pre-test, in which the counseling premises contained in the Handbook of Viral Hepatitis Counseling of the Ministry of Health 13 14 ; e) examination results, called post-test, the moment the researchers had the opportunity to clarify any doubts; f ) after a negative result, this was noted on the completed form and the participants were released with a copy of the printed report; g) in the event of the occurrence of a positive result the subjects were immediately scheduled in the Municipal STD/AIDS and Hepatitis Program to confirm the diagnosis and for subsequent treatment according to the clinical criteria proposed by the Clinical Protocol and Thera- 16 . In this study, confirmation was made by means of the third generation enzyme immunoassay (EIA), or ELISA--III, which detects antibodies directed against several epitopes of the C virus located in the capsid.…”

Section: Methodsmentioning

confidence: 99%

Prevalência da hepatite viral C em adultos usuários de serviço público de saúde do município de São José dos Pinhais - Paraná

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Cubas

Kusma

et al. 2012

Rev. bras. epidemiol.

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Section: Methodsmentioning

confidence: 99%

Prevalência da hepatite viral C em adultos usuários de serviço público de saúde do município de São José dos Pinhais - Paraná

Neto

Cubas

Kusma

et al. 2012

Rev. bras. epidemiol.

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“…All blood donors with a positive or indeterminate enzyme-linked immunosorbent assay (ELISA) anti-hCV test (third and fourth generation) who were seen at the uberaba regional Blood Center between November 1992 and December 2005 were studied, as explained in a previous paper 6 . The donors were first divided into first-time donors and repeat donors.…”

Section: Methodsmentioning

confidence: 99%

Epidemiological profile of hepatitis C in blood donors at the Uberaba Regional Blood Center

Garcia

Pereira

Martins

et al. 2009

Rev. Soc. Bras. Med. Trop.

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The aim of the present study was to outline the serological profile of hepatitis C among blood donors seen at the uberaba regional Blood Center, hemominas Foundation, over the last 14 years. The frequency of hepatitis C was compared between first-time and repeat donors and the epidemiological characteristics of those with positive and indeterminate ELISA anti-hCV (third and fourth generation) were analyzed based on the donor histories kept in the archives of the uberaba regional Blood Center. The serological ineligibility rate was 0.3%, with higher prevalence in the group of firsttime donors. We did not find any significant differences regarding age, skin color, marital status or place of residence between eligible and ineligible donors; however, the frequency of positive serology was higher among men. The lower (0.3%) rate of ineligibility due to hepatitis C that was observed at the uberaba regional Blood Center, in relation to most Brazilian blood centers, is probably due to the large number of repeat donors (83.3%). This reinforces the importance of achieving donor commitment for increasing transfusion safety. Key-words:Blood donor. Serological screening. hepatitis C. Epidemiology. RESuMOO objetivo deste estudo foi traçar o perfil sorológico para a hepatite C nos doadores de sangue do hemocentro regional de uberaba/Fundação hemominas nos últimos 14 anos, comparando a sua ocorrência em doadores iniciais e de retorno e analisando as características epidemiológicas daqueles com ELISA anti-hCV (terceira e quarta geração) positivo e indeterminado, a partir dos históricos dos doadores nos arquivos do hemocentro regional de uberaba. A inaptidão sorológica encontrada foi de 0,3%, com maior ocorrência no grupo de doadores iniciais. Não encontramos diferenças significativas quanto à idade, cor da pele, estado civil e local de residência entre os aptos e os inaptos, porém a ocorrência de sorologia positiva foi maior nos homens. A menor prevalência de inaptidão para hepatite C (0,3%) no hemocentro regional de uberaba, em relação à maioria dos hemocentros do país, é provavelmente devido ao grande (83,3%) número de doadores de repetição, reforçando assim a importância da fidelização do doador para o aumento da segurança transfusional. The hepatitis C virus (hCV) was identified in 1989 by Choo et al 5 and current estimates indicate that 130 million people worldwide are infected 7 . hCV is transmitted through infected blood and its derivatives, by means of percutaneous exposure (shared use of syringes by drug addicts, tattooing and accidents with biological material), and possibly through domestic or sexual contact with hCV-infected persons. In approximately 30% of hepatitis C cases, no risk factor can be identified 2 . Vertical transmission is rare when compared with hepatitis B; however, pregnant women with a high hCV load or coinfected with hIV are at greater risk of transmitting the disease to their children 14 . According to the World health Organization, shared use of syringes by intravenous drug users is the m...

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“…Studies have shown that with the new technique, the 'immunological window' is reduced from 22 to 10 days for HIV infections and from 90 to 15 days for HCV infections. Studies carried out in the HRU in 2008 and in a blood bank in São Paulo in 2004 also support the implementation of this method (19,20) . A work published in 2011 also defends the use of increasingly sensitivity and specific serological screening methods in an attempt to increase transfusion safety (21) .…”

Section: Discussionmentioning

confidence: 86%

The importance of hemovigilance in the transmission of infectious diseases

Martins

Barbosa

et al. 2013

Revista Brasileira De Hematologia E Hemoterapia

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BackgroundHemovigilance is an organized system of surveillance throughout the transfusion chain intended to evaluate information in order to prevent the appearance or recurrence of adverse reactions related to the use of blood products. ObjectiveThe aims of this study were to assess the late reporting of incidents related to possible seroconversion in respect to age, marital status and ethnical background, annual variations in late reporting, the number of reports opened and closed, seroconversion of donors and transfusions of blood products within the window period. MethodsThis retrospective, descriptive study used data on blood donations in the blood bank in Uberaba during the period from 2004 to 2011. Some socio-epidemiological characteristics of the donors and serology test results of donors and recipients were analyzed in respect to the late reporting of incidents related to possible seroconversion. The Chi-square test, odds ratio and a regression model were used for statistical analysis. ResultsFrom 2004 to 2011, the blood bank in Uberaba collected 117,857 blood bags, 284 (0.24%) of which were investigated for late reported incidents. The profile of the donors was less than 29 years old, unmarried and non-Whites. Differences in age (p-value < 0.0001), marital status (p-value = 0.0002) and ethnical background (p-value < 0.0001) were found to be statistically significant. There was no statistical difference between men and women (0.24% and 0.23% respectively; p-value = 0.951). The number of late reported incidents increased until 2008 followed by a downward trend until 2011. There were twelve cases of seroconversion in subsequent donations (seven human immunodeficiency virus, four hepatitis B and one hepatitis C) with proven human immunodeficiency virus infection after screening of only one recipient. ConclusionThe twelve cases of seroconversion in donors with subsequent infection proven in one recipient underscores the importance of this tool to increase transfusion safety.

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Importância dos testes sorológicos de triagem e confirmatórios na detecção de doadores de sangue infectados pelo vírus da hepatite C

Cited by 9 publications

References 11 publications

Prevalência da hepatite viral C em adultos usuários de serviço público de saúde do município de São José dos Pinhais - Paraná

Prevalência da hepatite viral C em adultos usuários de serviço público de saúde do município de São José dos Pinhais - Paraná

Epidemiological profile of hepatitis C in blood donors at the Uberaba Regional Blood Center

The importance of hemovigilance in the transmission of infectious diseases

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