Importance of zwitterionic incorporation into polymethacrylate-based hydrogels for simultaneously improving optical transparency, oxygen permeability, and antifouling properties

Wu, Jiang; He, Chaochao; He, Huacheng; Cheng, Chuanbing; Zhu, Junyi; Xiao, Zecong; Zhang, Hongyu; Li, Xiaokun; Zheng, Jie; Xiao, Jian

doi:10.1039/c7tb00757d

Cited by 39 publications

(35 citation statements)

References 62 publications

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“…The FTIR spectra of PHEMA and PHEMA/BA composite hydrogels were displayed in Figure . As demonstrated here, several absorption bands at 3429 (OH stretching vibration), 2958 and 2886 (CH 2 antisymmetric vibration), 1721 (CO stretching vibration), 1155 (COC antisymmetric vibration), and 1075 cm −1 (COC stretching vibration) are characteristic peaks of PHEMA hydrogel . On the other hand, all PHEMA/BA composite hydrogels are similar absorption peaks in the FTIR spectra and in this these peaks are overlapped with peaks from the PHEMA.…”

Section: Resultssupporting

confidence: 62%

Poly(2‐hydroxyethyl methacrylate)/boric acid composite hydrogel as soft contact lens material: Thermal, optical, rheological, and enhanced antibacterial properties

Ulu

Balcıoğlu

Birhanlı

et al. 2018

J of Applied Polymer Sci

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The present work proposes to fabricate a composite hydrogel material that well characterized, transparent, biocompatible, and self‐antibacterial as potential soft contact lens material. For this purpose, poly(2‐hydroxyethyl methacrylate) (PHEMA)/boric acid (BA) composite hydrogels were successfully prepared by chemical crosslinking with BA through in situ polymerization using different BA ratios between 1 and 10% w/w. Afterward, the compositions, thermal stability, transparence, oxygen permeability, water uptake capacity, swelling ratio as well as morphological and rheological properties, in vitro degradability, in vitro cytotoxicity, and antibacterial properties of the all prepared materials were analyzed using a series of different techniques. The thermal stability, hydrophilicity, water uptake, oxygen permeability gradually increased depending ratio of BA, which is desirable for biomaterial. While the transparence and refractive index decreased, the composite hydrogels, except for BA content of 10 wt %, maintained enough transparency to be used for contact lens. In addition, PHEMA/BA composite hydrogels exhibited good cytocompatibility (PHEMA‐1%BA and PHEMA‐3%BA) and excellent antibacterial activity against Gram‐positive (Staphylococcus aureus and Enterococcus faecium) and Gram‐negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. Overall, the results demonstrated that the obtained PHEMA/BA composite hydrogels could be considered as self‐antibacterial contact lens and a potential composite biomaterial for other applications. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46575.

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Section: Resultssupporting

confidence: 62%

Poly(2‐hydroxyethyl methacrylate)/boric acid composite hydrogel as soft contact lens material: Thermal, optical, rheological, and enhanced antibacterial properties

Ulu

Balcıoğlu

Birhanlı

et al. 2018

J of Applied Polymer Sci

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“…The reduction of platelet deposition associated with SB block copolymer conjugation are likely related to changes of the surface properties and the reduced protein (e.g., fibrinogen) adsorption, as confirmed in our previous study. 52 The antifouling mechanisms associated with zwitterion-modified surfaces have also been extensively considered in terms of surface property changes (interactions with water and salts) in previous publications 53,54 while the antifouling effectiveness on the SB modified surface could be variable based upon salt concentration, buffer composition, solution pH level and temperature. 55,56 The majority of studies developing thromboresistant coatings have focused on a single material and application.…”

Section: Figurementioning

confidence: 99%

Development of zwitterionic sulfobetaine block copolymer conjugation strategies for reduced platelet deposition in respiratory assist devices

Malkin

Lee

et al. 2018

J Biomed Mater Res

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Respiratory assist devices, that utilize ∼2 m of hollow fiber membranes (HFMs) to achieve desired gas transfer rates, have been limited in their adoption due to such blood biocompatibility limitations. This study reports two techniques for the functionalization and subsequent conjugation of zwitterionic sulfobetaine (SB) block copolymers to polymethylpentene (PMP) HFM surfaces with the intention of reducing thrombus formation in respiratory assist devices. Amine or hydroxyl functionalization of PMP HFMs (PMP-A or PMP-H) was accomplished using plasma-enhanced chemical vapor deposition. The generated functional groups were conjugated to low molecular weight SB block copolymers with N-hydroxysuccinimide ester or siloxane groups (SBNHS or SBNHSi) that were synthesized using reversible addition fragmentation chain transfer polymerization. The modified HFMs (PMP-A-SBNHS or PMP-H-SBNHSi) showed 80-95% reduction in platelet deposition from whole ovine blood, stability under the fluid shear of anticipated operating conditions, and uninhibited gas exchange performance relative to non-modified HFMs (PMP-C). Additionally, the functionalization and SBNHSi conjugation technique was shown to reduce platelet deposition on polycarbonate and poly(vinyl chloride), two other materials commonly found in extracorporeal circuits. The observed thromboresistance and stability of the SB modified surfaces, without degradation of HFM gas transfer performance, indicate that this approach is promising for longer term pre-clinical testing in respiratory assist devices and may ultimately allow for the reduction of anticoagulation levels in patients being supported for extended periods. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2681-2692, 2018.

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“…The collagen capsules of the tissue gradually form at the interface between tissue and implant materials due to the inflammatory response. Masson trichrome stain, which stains collagen blue, was used to evaluate capsule formation after subcutaneous implantation for 1 month ( Figure 8 ) [ 53 ]. As shown in Figure 8 B,C, crosslinked electrospun gelatin scaffold was still nondegraded, whereas the Gel–HPA fibrous hydrogel was almost entirely biodegraded after in vivo implantation for one month.…”

Section: Resultsmentioning

confidence: 99%

Enzyme-Crosslinked Electrospun Fibrous Gelatin Hydrogel for Potential Soft Tissue Engineering

et al. 2020

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Soft tissue engineering has been seeking ways to mimic the natural extracellular microenvironment that allows cells to migrate and proliferate to regenerate new tissue. Therefore, the reconstruction of soft tissue requires a scaffold possessing the extracellular matrix (ECM)-mimicking fibrous structure and elastic property, which affect the cell functions and tissue regeneration. Herein, an effective method for fabricating nanofibrous hydrogel for soft tissue engineering is demonstrated using gelatin–hydroxyphenylpropionic acid (Gel–HPA) by electrospinning and enzymatic crosslinking. Gel–HPA fibrous hydrogel was prepared by crosslinking the electrospun fibers in ethanol-water solution with an optimized concentration of horseradish peroxidase (HRP) and H2O2. The prepared fibrous hydrogel held the soft and elastic mechanical property of hydrogels and the three-dimensional (3D) fibrous structure of electrospun fibers. It was proven that the hydrogel scaffolds were biocompatible, improving the cellular adhesion, spreading, and proliferation. Moreover, the fibrous hydrogel showed rapid biodegradability and promoted angiogenesis in vivo. Overall, this study represents a novel biomimetic approach to generate Gel–HPA fibrous hydrogel scaffolds which have excellent potential in soft tissue regeneration applications.

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Importance of zwitterionic incorporation into polymethacrylate-based hydrogels for simultaneously improving optical transparency, oxygen permeability, and antifouling properties

Abstract: The introduction of zwitterionic SBMA into HEMA hydrogels enables to improve optical transparency, oxygen permeability, and antifouling property for contact lenses-based ophthalmic applications.

Cited by 39 publications

References 62 publications

Poly(2‐hydroxyethyl methacrylate)/boric acid composite hydrogel as soft contact lens material: Thermal, optical, rheological, and enhanced antibacterial properties

Poly(2‐hydroxyethyl methacrylate)/boric acid composite hydrogel as soft contact lens material: Thermal, optical, rheological, and enhanced antibacterial properties

Development of zwitterionic sulfobetaine block copolymer conjugation strategies for reduced platelet deposition in respiratory assist devices

Enzyme-Crosslinked Electrospun Fibrous Gelatin Hydrogel for Potential Soft Tissue Engineering

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