volume 269, issue 1, P195-202 2004
DOI: 10.1016/j.ijpharm.2003.09.005
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Abstract: BMS-480188 is a weak base. The aqueous solubility of BMS-480188 is 0.036 mg/ml at pH 6.5 at 37 degrees C. The mesylate salt of BMS-480188 was prepared to improve its solubility. Capsules containing mesylate salt alone (Formulation A) or mesylate salt with excipients, including lactose, croscarmellose sodium, sodium lauryl sulfate, syloid and magnesium stearate (Formulation B), were prepared. Both formulations show similar dissolution profiles in 1l 0.01N HCl at 37 degrees C. However, the bioavailability of For…

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