PLoS ONE volume 9, issue 7, Pe98323 2014 DOI: 10.1371/journal.pone.0098323 View full text
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Francesca Fiorentino, Chris A. Rogers, Alan J. Bryan, Gianni D. Angelini, Barnaby C. Reeves

Abstract: ObjectiveCharacterisation of anticoagulant control is fundamental to investigations of its association with clinical outcome. Anticoagulant control depends on several factors. This paper aims to illustrate the implications of different methods for measuring and analysing anticoagulant control in patients with second generation mechanical heart valve prostheses.MethodsInternational normalised ratio (INR) data collected during the 10-year follow-up of a randomised controlled trial were analysed. We considered th…

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