2017
DOI: 10.3892/etm.2017.5515
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Abstract: Breast cancer represents one of the most common forms of cancer in women worldwide, with an increase in the number of newly diagnosed patients in the last decade. The role of fatty acids, particularly of a diet rich in ω-3 and ω-6 polyunsaturated fatty acids (PUFAs), in breast cancer development is not fully understood and remains controversial due to their complex mechanism of action. However, a large number of animal models and cell culture studies have demonstrated that high levels of ω-3 PUFAs have an inhi… Show more

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Cited by 46 publications
(51 citation statements)
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References 117 publications
(162 reference statements)
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“…Increasing evidence suggests that n-3 PUFA, but not n-6 PUFAs, have anticancer activity and improve the effectiveness of conventional cancer therapy [5][6][7][8][9][10][11][12][13][14]. However, the analysis of PUFAs-enriched diet effects on breast cancer appearance and progression is complex and controversial due to the multitude of cancer typologies and origins and the pleiotropic effect of PUFAs [15][16][17]. Docosahexaenoic acid (DHA, 22:6n-3) is a polyunsaturated fatty acid with its first double bond at the n-3 (or omega-3) position (n-3 PUFA).…”
Section: Introductionmentioning
confidence: 99%
“…Increasing evidence suggests that n-3 PUFA, but not n-6 PUFAs, have anticancer activity and improve the effectiveness of conventional cancer therapy [5][6][7][8][9][10][11][12][13][14]. However, the analysis of PUFAs-enriched diet effects on breast cancer appearance and progression is complex and controversial due to the multitude of cancer typologies and origins and the pleiotropic effect of PUFAs [15][16][17]. Docosahexaenoic acid (DHA, 22:6n-3) is a polyunsaturated fatty acid with its first double bond at the n-3 (or omega-3) position (n-3 PUFA).…”
Section: Introductionmentioning
confidence: 99%
“…The relationship between monounsaturated fatty acids (MUFAs) and BC risk is more conflicting, and seems to depend on the contributing food source, such as olive oil and margarines [ 5 , 7 ]. On the other hand, higher consumption of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) as well as elevated intake of n-3/n-6 PUFA ratio seem to exert a protective effect on this tumor [ 5 , 7 , 9 , 10 , 11 , 12 ]. To assess the usual intake of fatty acids, these studies were based on commonly-used dietary questionnaires.…”
Section: Introductionmentioning
confidence: 99%
“…For example, the combination of EPA and DHA decreases the production of eicosanoids formed from AA, leading to the inactivation of NF-κB and hindering proliferation [ 46 ]. They are also able to inhibit the activity of AKT protein, which is involved in cell survival and the inhibition of apoptotic processes [ 49 ]. Furthermore, PUFAs are involved in different processes such as lipid peroxidation, cell oxidative stress [ 50 , 51 ] and regulation of gene expression for controlling growth factor mediated carcinogenesis [ 52 ].…”
Section: Fatty Acids and Lipid Supply For Membrane Formation In Camentioning
confidence: 99%