Implications of dietary oils and polyunsaturated fatty acids in the management of cutaneous disorders

Ziboh, V. A.

doi:10.1001/archderm.125.2.241

Cited by 12 publications

(5 citation statements)

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“…It has been shown that oral PUFA administration is associated with an alteration of plasma fatty acids in mice (12) and with their increased incorporation into skin (17). PUFA play an important role for the integrity of the stratum corneum and are essential for maintaining a regular function and structure of the skin barrier (18).…”

Section: Discussionmentioning

confidence: 99%

Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen‐induced dermatitis in mice

Weise

Heunemann

Loddenkemper

et al. 2011

Pediatric Allergy Immunology

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Dietary DHA/AA supplementation leads to a significant amelioration of allergen-induced dermatitis. This was accompanied with the presence of increased regulatory T cells and IL-10 expression in lesional skin. Moreover, we identify keratinocytes, which play a crucial role in the regulation of skin inflammation, as important targets of DHA/AA supplementation. Future studies are needed to clarify whether DHA/AA acts directly or whether its biologic active metabolites are responsible for these findings. This may unravel novel therapeutical compounds for allergen-induced dermatitis.

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Section: Discussionmentioning

confidence: 99%

Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen‐induced dermatitis in mice

Weise

Heunemann

Loddenkemper

et al. 2011

Pediatric Allergy Immunology

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“…The recent observation that a diet poor in long‐chain fatty acids and enriched with medium‐chain fatty acids improved skin and liver manifestations 7,19 suggests that an early initiation of such a diet might prevent systemic disturbances and improve skin alterations.…”

Section: Discussionmentioning

confidence: 99%

Erythrokeratoderma variabilis-like ichthyosis in Chanarin-Dorfman syndrome

Pujol¹,

Gilaberte²,

Toll³

et al. 2005

Br J Dermatol

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Neutral lipid storage disease (Chanarin-Dorfman syndrome) is an autosomal recessive metabolic disorder associated with congenital ichthyosis and a multisystemic accumulation of neutral lipids (lipid droplets) in various types of cells. The clinical presentation has been reported to correspond to that of nonbullous congenital ichthyosiform erythroderma. We report a 4-year-old boy presenting a generalized ichthyosiform disorder manifested by migrating scaly plaques alternating with areas of normal-looking skin, showing erythematous borders with sharp margins, clinically suggestive of erythrokeratoderma variabilis (EKV). A peripheral blood smear revealed cytoplasmic vacuoles in most granulocytes. Genetic studies from the patient and his parents revealed that the patient carried two different and novel mutations of the ABHD5 gene: a nonsense mutation in exon 6 (transmitted by the father) and an insertion/deletion in exon 4 (transmitted by the mother). Our observation demonstrates the clinical heterogeneity of the ichthyosiform dermatoses observed in Chanarin-Dorfman syndrome and widens the clinical range of conditions presenting migrating scaly plaques mimicking EKV.

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“…In vitro and in vivo studies have shown GLA to selectively kill tumor cells without harming normal cells (Reddy and others 1998). GLA is also implicated in the amelioration of a number of diseased states including schizophrenia, multiple sclerosis, dermatitis, diabetes, and rheumatoid arthritis (Ziboh 1989; Sajilata and others 2008).…”

Section: Current Uses Of Microalgae As Foodmentioning

confidence: 99%

Microalgae for “Healthy” Foods—Possibilities and Challenges

Chacón-Lee¹,

González-Mariño²

2010

Comp Rev Food Sci Food Safe

341

149

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Microalgae have the potential to become a novel source of bioactive molecules, especially for those who might wish to enhance the nutritional and functional quality of foods. Spirulina, one of the most popular microalgae, has been described by the World Health Organization as one of the greatest superfoods on earth serving as an example of the potential of microalgae. This review provides background on current and future uses of microalgae in the human diet, lists the most common species of microalgae used to this end, and describes some production methods used in research and industrial production and recovery. The review also discusses some of the difficulties so far encountered such as low productivities and recovery rates, as well as challenges in the production of compounds of interest. Many scientists and engineers in research centers around the globe are currently dedicated to solve these problems as the various capabilities of microalgae have caught the attention of the energy, environmental, and agricultural industries, we propose that the food industry should as well evaluate the potential of microalgae as a novel source of "health promoting" compounds.

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Implications of dietary oils and polyunsaturated fatty acids in the management of cutaneous disorders

Cited by 12 publications

References 0 publications

Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen‐induced dermatitis in mice

Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen‐induced dermatitis in mice

Erythrokeratoderma variabilis-like ichthyosis in Chanarin-Dorfman syndrome

Microalgae for “Healthy” Foods—Possibilities and Challenges

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