Implication of the HLA-DRB3 gene in graves' disease: Predominance of Allele Dw24

Sémana, G.; Allanic, H; Quillivic, F.; Vallejo, Marie-Thérèse; Simon, Jean‐Pierre; Genetet, B; Fauchet, R.

doi:10.1016/0198-8859(90)90077-3

Cited by 11 publications

(8 citation statements)

References 15 publications

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“…While the increased prevalence of HLA-DR3 has been confirmed in several studies, the association with HLA-DR5 (another member of the HLA-DRw52 family) was only inconsistent [1,2,10,[17][18][19]. The present study strengthens evidence of an association with serologically defined HLA specificities HLA-DR3 and of HLA-DR5 when combined with HLA-DR3.…”

Section: Discussionsupporting

confidence: 74%

“…These HLA specificities belong to the HLADRw52 family characterized by the presence of the HLA-DRB3 gene [3,24]. The heterogeneity of the HLA-DRB3 gene products has been described using molecular techniques [1,5,9,10,19]. Recently we found an association of an HLADRw52 subtype (i.e., the HLA-DRB3*0101) allele with GD in a small group of patients [1].…”

mentioning

confidence: 91%

“…Recently we found an association of an HLADRw52 subtype (i.e., the HLA-DRB3*0101) allele with GD in a small group of patients [1]. In a larger survey from France, the HLA-DRB3*0101 allele was also found to be the strongest susceptibility marker in this population [19].…”

mentioning

confidence: 97%

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HLA-DRB3 gene alleles in Caucasian patients with Graves' disease

et al. 1992

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Graves' disease (GD) is a human leukocyte antigen (HLA) linked organ-specific autoimmune disease. In German GD patients the disease is associated with HLA specificities of the HLA-DRw52 family (HLA-DR3, -DR5, and DR6; HLA-DRB3 positive HLA haplotypes). Recently, a strong association with a HLA-DRB3 restriction fragment length polymorphism gene has been described. To study HLA-DRB3 alleles and their association with the disease, a large cohort of controls (n = 3724) and GD patients (n = 304) was analyzed. HLA-DR allelic combinations revealed an increase in HLA-DR3/DR5 heterozygous patients (relative risk 2.9; P < 0.001). HLA-DRB3 alleles, as defined by DNA typing in HLA-DR matched groups revealed a significant increase in DRB3*0101 homozygosity (relative risk 17.5; P < 0.001) in HLA-DR3 homozygous patients. In GD patients with ophthalmopathy (grade II or higher, according to Werner) DRB3*0101/*0202 heterozygosity revealed an increased relative risk of 5.5 (P < 0.001). Non-HLA-DR3 homozygous, DRB3*0101/*0202 heterozygous patients were at the highest risk for endocrine ophthalmopathy (relative risk 10; P < 0.001). Our data, based on DNA typing methods of HLA-D genes, provide evidence that the susceptibility is strongly associated with HLA-DRB3 genes.

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Section: Discussionsupporting

confidence: 74%

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confidence: 91%

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HLA-DRB3 gene alleles in Caucasian patients with Graves' disease

et al. 1992

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“…DRB3 is known to be associated with Graves' disease, as in our study here and as previously reported by others in patients with a variety of ages of disease onset (5,22). However, DRB1*03 and DRB3 are in such tight linkage disequilibrium (23) that it has been difficult to identify which is the primary locus.…”

Section: Discussioncontrasting

confidence: 41%

HLA-DRB1108, DRB1103/DRB310101, and DRB310202 Are Susceptibility Genes for Graves’ Disease in North American Caucasians, Whereas DRB1107 Is Protective1

Chen

Huang

She

et al. 1999

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…HLA association with autoimmune endocrinopathies in Caucasian populations is stronger for Type 1 diabetes, where DQB1*0201 and DQB1'0302 occur in more than 90% of affected individuals, while DQBl*O602 is negatively correlated with the disease (Todd et al, 1987;Deschamps & Khalil, 1993). HLA-DR3 frequency is also significantly increased in individuals with Addison's disease and Graves' disease (Semana et al, 1990) and a positive association with DR4/DR5 in Hashimoto's thyroiditis has been reported (Roman et al, 1992), although the association of Hashimoto's thyroiditis with DR5 is controversial (Jenkins et al, 1992) but it is close with DR3. The predisposition for Graves' disease in the Caucasoid population is localized to the HLA-DRB3 genes and homozygosity of HLA-DRB3*0101 alleles confers a high relative risk (Bohm et al, 1992).…”

Section: Genetic Susceptibilitymentioning

confidence: 99%

Lymphocytic traffic and homing into target tissue and the generation of endocrine autoimmunity

Pozzilli

Carotenuto

Delitala

1994

Clinical Endocrinology

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Summary Endocrine autoimmunity is known to be characterized by the presence of specific autoantibodies and from the histopathological point of view by lymphocytic inflitration in the target tissue. The presence of mononuclear cell infiltrates is the pathological hallmark of most endocrine diseases characterized by an autoimmune process directed against antigens expressed on endocrine cells. Infiltrating cells can usually be detected by biopsy or by using other, non‐invasive, techniques. However, in endocrine tissue such as the islets of Langerhans and the adrenal glands it is difficult to perform biopsies and diagnosis of the autoimmune process is dependent mainly upon detection of specific autoantibodies. A crucial aspect of endocrine autoimmunity and of all processes of organ specific autoimmunity is why and how lymphocytes migrate from primary lymphoid tissue to their specific targets. This occurs mainly through contact with specific adhesion molecules which enable lymphocytes to adhere to the endothelial vessels. In close proximity to the target tissue. In this review we discuss the homing of peripheral mononuclear cells into target endocrine tissues and the mediating role of adhesion molecules.

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Implication of the HLA-DRB3 gene in graves' disease: Predominance of Allele Dw24

Cited by 11 publications

References 15 publications

HLA-DRB3 gene alleles in Caucasian patients with Graves' disease

HLA-DRB3 gene alleles in Caucasian patients with Graves' disease

HLA-DRB1108, DRB1103/DRB310101, and DRB310202 Are Susceptibility Genes for Graves’ Disease in North American Caucasians, Whereas DRB1107 Is Protective1

Lymphocytic traffic and homing into target tissue and the generation of endocrine autoimmunity

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