2018
DOI: 10.18632/aging.101502
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Abstract: With increases in life expectancy, it is vital to understand the dynamics of aging, their interaction with lifestyle factors, and the connections to age-related disease processes. Our work on environmental enrichment (EE), a housing environment boosting mental health, has revealed a novel anticancer and anti-obesity phenotype mediated by a brain-fat axis: the hypothalamic-sympathoneural-adipocyte (HSA) axis in young animals. Here we investigated EE effects on healthspan and lifespan when initiated after middle… Show more

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Cited by 26 publications
(44 citation statements)
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References 89 publications
(84 reference statements)
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“…We have investigated whether environmental modulation of the HSA axis and adjacent neuro-immuno-endocrine mechanisms could promote healthy aging and increase healthspan in murine models. Consistent with previous work in younger mice, short-term EE (6 weeks) in middle-age mice (10 months old) was able to stimulate hypothalamic BDNF as well as associated improvements in metabolism and related molecular pathways ( 82 ). These results acted as a proof-of-concept for the use of EE in aged models, indicating that even a short exposure of EE could yield a meaningful phenotype for future studies.…”
Section: Hsa Axis Modulation Of Healthy Systemic Agingsupporting
confidence: 89%
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“…We have investigated whether environmental modulation of the HSA axis and adjacent neuro-immuno-endocrine mechanisms could promote healthy aging and increase healthspan in murine models. Consistent with previous work in younger mice, short-term EE (6 weeks) in middle-age mice (10 months old) was able to stimulate hypothalamic BDNF as well as associated improvements in metabolism and related molecular pathways ( 82 ). These results acted as a proof-of-concept for the use of EE in aged models, indicating that even a short exposure of EE could yield a meaningful phenotype for future studies.…”
Section: Hsa Axis Modulation Of Healthy Systemic Agingsupporting
confidence: 89%
“…Mental stimulation, social partners, and additional complex stimuli may play a role in healthy aging and anti-cancer processes. As discussed previously ( 6 , 28 , 82 ), the full benefits of EE could not be recapitulated with exercise alone, indicating the importance of other factors in environmental activation of the HSA axis and adjacent neural-immuno-endocrine mechanisms.…”
Section: Discussion and Future Directionsmentioning
confidence: 74%
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“…EE housing provides animals with speciesappropriate cognitive, motor, sensory, and social stimuli with novelty and complexity. Compared to standard lab housing environments (SE), EE reduces age-related obesity, reduces hepatosteatosis, and improves glycemic control [8]. We previously identified a specific brainadipose axis, the hypothalamic-sympathoneural-adipocyte (HSA) axis, through which EE-induced hypothalamic brain-derived neurotrophic factor (BDNF) expression leads to increased sympathetic tone to adipose tissue [9,10].…”
Section: Agingmentioning
confidence: 99%
“…We have used a mouse model of environmental enrichment (EE) to study an active lifestyle influence on health and diseases (Cao et al 2004, Cao & During 2012, During et al 2015, Foglesong et al 2016, Xiao et al 2016, 2019, Mcmurphy et al 2018. EE refers to a housing with increased space, physical activity and social interactions that facilitate enhanced sensory, cognitive, motor and social stimulation (Nithianantharajah & Hannan 2006).…”
Section: Introductionmentioning
confidence: 99%