Implantation of Stimulation Electrodes in the Subretinal Space to Demonstrate Cortical Responses in Yucatan Minipig in the Course of Visual Prosthesis Development

Sachs, Helmut; Gekeler, Florian; Schwahn, Hartmut; Jakob, Wolfgang; Kohler, M; Schulmeyer, Frank J.; Marienhagen, J.; Brunner, U; Framme, Carsten

doi:10.1177/112067210501500413

Cited by 29 publications

(25 citation statements)

References 17 publications

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“…The anatomic similarities to human eyes, along with comparable physiologic processes, enable miniature swine to be good candidates for surgical procedures and reliable for model development and subsequent testing of potential therapeutic agents (Kyhn et al 2008;Rosolen, Rigaudiere, and Le Gargasson 2003;Sachs et al 2005). Swindle and Ravi 2007;Reilly et al 2008, Ruiz-Ederra et al 2005Shafiee et al 2008;Kyhn et al 2008;Iandiev et al 2006;Czajka et al 2004;Sachs et al 2005;Petters et al 1997). The pig does not have a tapetum lucidum, a true macula, or a fovea; they do have a cone-rich visual streak (Fernandez de Castro et al 2014).…”

Section: Ophthalmology Modelsmentioning

confidence: 99%

The Miniature Swine as a Model in Experimental and Translational Medicine

2016

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The use of the miniature swine as a nonrodent species in research has continued to expand for over a decade, and they are becoming routinely used both in experimental pharmacology and as a therapeutic model for human diseases. Miniature swine models are regularly used for studies designed to assess efficacy and safety of new therapeutic compounds given through different routes of exposure and are used as an alternative model to rodents, canines, or nonhuman primates. Translational preclinical swine study data presented here support the current understanding that miniature swine are the animal model of choice for the assessment of drugs targeting endocrine, dermal, and ocular disorders. Because research investigators need to be familiar with some of the important features of the models developed in the miniature swine in order to place clinical and experimental findings in their proper perspective, relevant references and data from these models will be presented, compared, and partially illustrated.

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Section: Ophthalmology Modelsmentioning

confidence: 99%

The Miniature Swine as a Model in Experimental and Translational Medicine

2016

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“…On the contrary, numerous functional studies dealing with specific regions of the cortex have been performed either in miniature or conventional domestic pig. According to the existing literature, we propose an approximate mapping of the pig's cortical areas in Figure 2.Functional studies have successfully explored the visual cortex of the pig with EP recordings (Laube et al, 2003;Sachs et al, 2005;Strain et al, 2006) or functional MRI (Fang et al, 2006;Gizewski et al, 2007). Exploration of the auditory cortices has also been addressed with EP recordings in miniature pig (Andrews et al, 1990) or cytoarchitectonic techniques in domestic pigs (Plogmann and Kruska, 1990).…”

mentioning

confidence: 99%

The pig model in brain imaging and neurosurgery

Sauleau

Lapouble

Val‐Laillet

et al. 2009

Animal

206

178

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The pig model is increasingly used in the field of neuroscience because of the similarities of its brain with human. This review presents the peculiarities of the anatomy and functions of the pig brain with specific reference to its human counterpart. We propose an approximate mapping of the pig's cortical areas since a comprehensive description of the equivalent of Brodmann's areas is lacking. On the contrary, deep brain structures are received more consideration but a true three-dimensional (3D) atlas is still eagerly required. In the second section, we present an overview of former works describing the use of functional imaging and neuronavigation in the pig model. Recently, the pig has been increasingly used for molecular imaging studies using positron emission tomography (PET). Indeed, the large size of its brain is compatible with the limited spatial resolution of the PET scanner built to accommodate a human being. Similarly, neuronavigation is an absolute requirement to target deep brain areas in human and in pig since the surgeon cannot rely on external skull structures for zeroing the 3D reference frame. Therefore, a large body of methodological refinements has been dedicated to image guided surgery in the pig model. These refinements allow now a millimetre precision: an absolute requirement for basal nuclei targeting. In the third section, several examples of ongoing studies in our laboratory were presented to illustrate the intricacies of using the pig model. For both examples, after a brief description of the scientific context of the experiment, we present, in detail, the methodological steps required to achieve the experimental goals, which are specific to the porcine model. Finally, in the fourth section, the anatomical variations depending on the breed and age are discussed in relation with neuronavigation and brain surgery. The need for a digitized multimodality brain atlas is also highlighted.Keywords: pig, neuroimaging, single photon emission tomography, neuronavigation, deep brain stimulation ImplicationsThe pig model is increasingly used in the field of neuroscience because of the similarities of its brain with human. Indeed, aside from the rodent model there is a critical need for a large animal model ethically acceptable, i.e. excluding non-human primates. In this review we present some experiments dealing with the various procedures achievable in the pig model ranging from image-guided brain surgery to functional brain imaging studies. The recent advances in functional imaging data processing pointed out our partial knowledge of pig brain neuro-anatomy and the requirement for a digitalized atlas matching MRI (magnetic resonance imaging) and histological resources. IntroductionSwine have been used extensively as a model of human in biomedical researches such as cardiovascular, metabolic and transplantation (Phillips et al., 1982;Larsen and Rolin, 2004;Imai et al., 2006;Groth, 2007). In the last decade, an increasing number of studies in the field of neuroscience has been reported (Lind et ...

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“…The species involved include rats (n=6) [26,29,76,80,81,96], rabbits (n=14) [33,36,42,72,73,90,94,95,102,103,105,106,116,121], cats (n=18) [18, 19, 21-23, 30, 32, 43, 78, 79, 82, 93, 98, 99, 101, 114, 117, 120], dogs (n=4) [16,39,40,66], sheep (n=1) [51] and pigs/minipigs (n=9) [34,42,49,59,69,91,92,100,102]. Two papers [16,26] which involved three animal species do not figure in Table 2 due to lack of space, but are discussed in the review.…”

Section: Resultsmentioning

confidence: 99%

“…Notwithstanding these limitations, minipigs and pigs have featured extensively in prosthesis research. Published studies include feasibility/safety of implant procedures [34,92], control of retinal-implant contact using impedance measurements [49], long-term biocompatibility [42,59,69,102], physiological effects of the implants using epidural recordings of evoked cortical potentials [59,91,92,100,102] and behavioural reactions to electrical stimulation [34].…”

Section: Pig/minipigmentioning

confidence: 99%

A review of in vivo animal studies in retinal prosthesis research

Bertschinger¹,

Beknazar²,

Silva

et al. 2008

Graefes Arch Clin Exp Ophthalmol

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Background The development of a functional retinal prosthesis for acquired blindness is a great challenge. Rapid progress in the field over the last 15 years would not have been possible without extensive animal experimentation pertaining to device design and fabrication, biocompatibility, stimulation parameters and functional responses. This paper presents an overview of in vivo animal research related to retinal prosthetics, and aims to summarize the relevant studies. Methods A Pubmed search of the English language literature was performed. The key search terms were: retinal implant, retinal prosthesis, artificial vision, rat, rabbit, cat, dog, sheep, pig, minipig. In addition a manual search was performed based on references quoted in the articles retrieved through Pubmed. Results We identified 50 articles relevant to in vivo animal experimentation directly related to the development of a retinal implant. The highest number of publications related to the cat (n=18). Conclusion The contribution of animal models to the development of retinal prosthetic devices has been enormous, and has led to human feasibility studies. Grey areas remain regarding long-term tissue-implant interactions, biomaterials, prosthesis design and neural adaptation. Animals will continue to play a key role in this rapidly evolving field.

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Implantation of Stimulation Electrodes in the Subretinal Space to Demonstrate Cortical Responses in Yucatan Minipig in the Course of Visual Prosthesis Development

Abstract: The feasibility of subretinal stimulation of the retina was demonstrated in a retinal model that is similar to the human retina. This animal model therefore offers a suitable means of studying the tolerability of stimulation situations in the course of visual prosthesis development.

Cited by 29 publications

References 17 publications

The Miniature Swine as a Model in Experimental and Translational Medicine

The Miniature Swine as a Model in Experimental and Translational Medicine

The pig model in brain imaging and neurosurgery

A review of in vivo animal studies in retinal prosthesis research

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