Implantable Micro-Light-Emitting Diode (µLED)-based optogenetic interfaces toward human applications

Lee, Jae Hee; Lee, Sinjeong; Kim, Daesoo; Lee, Keon Jae

doi:10.1016/j.addr.2022.114399

Cited by 13 publications

(7 citation statements)

References 170 publications

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“…Recently, micro-light-emitting diode (µLED) has been used to manufacture highly integrated optogenetic devices [101]. Because small devices can be directly implanted into target tissues, efficient light transmission and high-resolution control can be achieved through external power devices.…”

Section: Optogenetic Device Applicationsmentioning

confidence: 99%

Neural repair and regeneration interfaces: a comprehensive review

Sha,

2024

Biomed. Mater.

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Neural interfaces play a pivotal role in neuromodulation, as they enable precise intervention into aberrant neural activity and facilitate recovery from neural injuries and resultant functional impairments by modulating local immune responses and neural circuits. This review outlines the development and applications of these interfaces and highlights the advantages of employing neural interfaces for neural stimulation and repair, including accurate targeting of specific neural populations, real-time monitoring and control of neural activity, reduced invasiveness, and personalized treatment strategies. Ongoing research aims to enhance the biocompatibility, stability, and functionality of these interfaces, ultimately augmenting their therapeutic potential for various neurological disorders. The review focuses on electrophysiological and optophysiology neural interfaces, discussing functionalization and power supply approaches. By summarizing the techniques, materials, and methods employed in this field, this review aims to provide a comprehensive understanding of the potential applications and future directions for neural repair and regeneration devices.

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Section: Optogenetic Device Applicationsmentioning

confidence: 99%

Neural repair and regeneration interfaces: a comprehensive review

Sha,

2024

Biomed. Mater.

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“…These devices would allow for selective power increase via the optrode shank, without increase in light power to the cortical surface, while also positioning microLEDs in direct contact with optrode shanks, which minimizes light loss. This approach is currently limited by microLED power thresholds, but with advances in this area occurring rapidly, these devices might represent the ideal method of light delivery in NHP (reviewed in Hee Lee et al, 2022 ).…”

Section: Delivering Optical Stimulationmentioning

confidence: 99%

Optogenetics in primate cortical networks

Merlin

Vidyasagar

2023

Front. Neuroanat.

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The implementation of optogenetics in studies on non-human primates has generally proven quite difficult, but recent successes have paved the way for its rapid increase. Limitations in the genetic tractability in primates, have been somewhat overcome by implementing tailored vectors and promoters to maximize expression and specificity in primates. More recently, implantable devices, including microLED arrays, have made it possible to deliver light deeper into brain tissue, allowing targeting of deeper structures. However, the greatest limitation in applying optogenetics to the primate brain is the complex connections that exist within many neural circuits. In the past, relatively cruder methods such as cooling or pharmacological blockade have been used to examine neural circuit functions, though their limitations were well recognized. In some ways, similar shortcomings remain for optogenetics, with the ability to target a single component of complex neural circuits being the greatest challenge in applying optogenetics to systems neuroscience in primate brains. Despite this, some recent approaches combining Cre-expressing and Cre-dependent vectors have overcome some of these limitations. Here we suggest that optogenetics provides its greatest advantage to systems neuroscientists when applied as a specific tool to complement the techniques of the past, rather than necessarily replacing them.

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“…Optogenetic stimulation offers neuroscientists a unique tool for manipulating neuronal activity with precision, providing cell-type specificity and high spatial and temporal resolution (1,2). Until recently, longterm optogenetic wide-field manipulations in higher mammals were limited, but now become feasible through implantable stimulator arrays using single-photon-based stimulation (3,4). This advancement opens a path towards a sophisticated interrogation of sensory or motor code in meaningful volumes of cortex (3,(5)(6)(7)(8), as well as development of neuro-prosthetic systems for vision and hearing loss remediation (3,(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Optogenetic stimulation recruits cortical neurons in a morphology-dependent manner

Berling,

Baroni,

Chaffiol

et al. 2024

Preprint

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Optogenetic stimulation has recently proven effective for vision restoration in the human eye, underlining its clinical potential. Its application in sensory cortices could exploit the spatial organization of stimulus feature encoding along the cortical surface to induce artificial perception for restoring a lost sense. However, engaging sensory neuronal populations requires high stimulation precision, which is potentially limited by spatially extending neuronal morphology. Here, we characterize how morphology impacts spatial stimulation precision using an experimentally validated computational model. We show that morphology limits precision at a scale of several hundred micrometers and that the spatial distribution of direct neuronal activation is non-linearly dependent on the stimulation intensity. We compare precision in pyramidal neurons from layers 2/3 and 5 and explore the potential of improving precision through preferentially somatic opsin expression and stimulator design, revealing complex relationships. Our findings have important implications for interpreting existing experimental data and for optimizing future optogenetic interventions.

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Implantable Micro-Light-Emitting Diode (µLED)-based optogenetic interfaces toward human applications

Cited by 13 publications

References 170 publications

Neural repair and regeneration interfaces: a comprehensive review

Neural repair and regeneration interfaces: a comprehensive review

Optogenetics in primate cortical networks

Optogenetic stimulation recruits cortical neurons in a morphology-dependent manner

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