2016
DOI: 10.1038/nm.4162
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Abstract: Orthopedic implants containing biodegradable magnesium have been used for fracture repair with considerable efficacy; however, the underlying mechanisms by which these implants improve fracture healing remain elusive. Here we show the formation of abundant new bone at peripheral cortical sites after intramedullary implantation of a pin containing ultrapure magnesium into the intact distal femur in rats. This response was accompanied by substantial increases of neuronal calcitonin gene-related polypeptide-α (CG… Show more

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Cited by 667 publications
(479 citation statements)
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References 68 publications
(97 reference statements)
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“…The magnesium ion released from the coating could transport to the periosteal region through Harversian’s or Volkmann’s canals since the diameter of magnesium ion (<300 pm) is much smaller than that of Harversian’s or Volkmann’s canals55. The bone cells were recruited to the surface and inside of the titanium alloy and facilitated the new bone formation.…”
Section: Discussionmentioning
confidence: 99%
“…The magnesium ion released from the coating could transport to the periosteal region through Harversian’s or Volkmann’s canals since the diameter of magnesium ion (<300 pm) is much smaller than that of Harversian’s or Volkmann’s canals55. The bone cells were recruited to the surface and inside of the titanium alloy and facilitated the new bone formation.…”
Section: Discussionmentioning
confidence: 99%
“…However, mainly due to the lack of adequate mammalian genetic models, it still remains unclear whether an imbalance in Mg 2+ metabolism is merely associated with or can directly trigger the latter pathophysiological processes. Furthermore, it has recently been shown that cellular Mg 2+  fluxes regulate the circadian rhythm and energy balance (Feeney et al, 2016), CGRP-mediated osteogenic differentiation (Zhang et al, 2016) and synaptic plasticity (Palacios-Prado et al, 2014), and that changes in the composition of brain interstitial Mg 2+  concentrations participate in the control of the sleep-wake cycle (Ding et al, 2016). …”
Section: Introductionmentioning
confidence: 99%
“…Mg encourages osteogenesis [18], which has clear potential for orthopaedic applications [2]. Furthermore, the corrosion products of the Mg implant may be beneficial in certain applications [1].…”
Section: Medical Magnesium and Biocorrosionmentioning
confidence: 99%
“…The selection of appropriate animal models which reflect or match the part of the targeted part of the human system most effectively is a topic which gathers much discussion and research in biomedical materials [118,119]. For orthopaedic applications small animal studies are generally conducted in rodents such as rats or rabbits [18,27,120,121]. For larger animal studies sheep [122] and pigs [123] have been used previously, with dogs and goats also established in the field [119].…”
Section: Consideration For Selecting An Appropriate In Vivo Modelmentioning
confidence: 99%