Impetigo herpetiformis and hypoparathyroidism

Impetigo herpetiformis during the Puerperium

“…A 64-year-old woman presented recurrent impetigo herpetiformis triggered by episodes of hypocalcemia secondary to postsurgical hypoparathyroidism, the correction of the hypocalcemia resulting in quick improvement of the skin disease. Although best known for its association with pregnancy, impetigo herpetiformis should also be considered an important manifestation of the postthyroidectomy syndrome [15]. Subsequent pregnancies of the patients are not recommended by some authors [16].…”

Generalized Pustular Psoriasis of Pregnancy (Impetigo herpetiformis)

“…Baker and Ryan [1], found only 15 patients without any previous manifestation of psoriasis in their large study on 104 patients with generalized pustular psoriasis. Other accompanying symptoms described in impetigo herpetiformis are hormonal dysregulation with possible placental insufficiency and hypercalcemia as described in hyperparathyroidism (mostly after injury of the parathyroid glands during strumectomy) [5, 6, 7]. …”

“…Since these findings are not commonly associated with reported cases of impetigo herpetiformis, the causal relationship that is discussed in single cases remains speculative [5, 12]. Sporadic cases with hypoalbuminemia probably due to the loss of albumin in large exudative areas have been reported [14].…”

“…Besides other causes of a disseminated spread of pustules and blisters, differential diagnosis includes also impetigo herpetiformis, of which nearly 100 cases have been reported until now. This disease has been observed in pregnancy with and without hormonal dysregulations [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14]. In the more recent literature, this disease is considered to be a generalized manifestation of pustular psoriasis [5, 6, 14].…”

“…This disease has been observed in pregnancy with and without hormonal dysregulations [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14]. In the more recent literature, this disease is considered to be a generalized manifestation of pustular psoriasis [5, 6, 14]. We report an impressive case of impetigo herpetiformis because the coexistence of typical papulosquamous lesions of psoriasis is in keeping with the concept that this disease represents a variant of psoriasis.…”