Impairment of the executive function in breast cancer patients receiving chemotherapy treatment: a functional MRI study

Liu, Tao; Lin, Hailong; Yan, Yuchun; Xu, Xiaojun; Wang, L.; Zhang, J.; Yu, Yongqiang

doi:10.1111/ecc.12553

Cited by 37 publications

(30 citation statements)

References 55 publications

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“…The median PM2.5 in study homes was higher (33 μg/m 3 ) than seen in a multistate study of homes with woodstoves (17.5 μg/m 3 ) 27 and was higher than World Health Organization recommendations. 23 Elevated PM2.5 was associated with increased cough between colds in household children.…”

Section: Discussioncontrasting

confidence: 67%

“…in respiratory symptoms 26. In addition, VOCs were present in all households, probably contributed by wood burning, tobacco smoke, fuel storage, and small engine repair in homes.The median PM2.5 in study homes was higher (33 μg/m 3 ) than seen in a multistate study of homes with woodstoves (17.5 μg/m 3 )27 and was higher than World Health Organization recommendations. In addition, VOCs were present in all households, probably contributed by wood burning, tobacco smoke, fuel storage, and small engine repair in homes.The median PM2.5 in study homes was higher (33 μg/m 3 ) than seen in a multistate study of homes with woodstoves (17.5 μg/m 3 )27 and was higher than World Health Organization recommendations.…”

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confidence: 67%

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Housing characteristics and indoor air quality in households of Alaska Native children with chronic lung conditions

et al. 2016

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Alaska Native children experience high rates of respiratory infections and conditions. Household crowding, indoor smoke, lack of piped water, and poverty have been associated with respiratory infections. We describe the baseline household characteristics of children with severe or chronic lung disease participating in a 2012-2015 indoor air study. We monitored indoor PM2.5, CO , relative humidity %, temperature, and VOCs and interviewed caregivers about children's respiratory symptoms. We evaluated the association between reported children's respiratory symptoms and indoor air quality indicators using multiple logistic regression analysis. Compared with general US households, study households were more likely overcrowded 73% (62%-82%) vs 3.2% (3.1%-3.3%); had higher woodstove use as primary heat source 16% (9%-25%) vs 2.1% (2.0%-2.2%); and higher proportion of children in a household with a smoker 49% (38%-60%) vs 26.2% (25.5%-26.8%). Median PM2.5 was 33 μg/m . Median CO was 1401 ppm. VOCs were detectable in all homes. VOCs, smoker, primary wood heat, and PM2.5>25 μg/m were associated with higher risk for cough between colds; VOCs were associated with higher risk for wheeze between colds and asthma diagnosis. High indoor air pollutant levels were associated with respiratory symptoms in household children, likely related to overcrowding, poor ventilation, woodstove use, and tobacco smoke.

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Section: Discussioncontrasting

confidence: 67%

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confidence: 67%

Housing characteristics and indoor air quality in households of Alaska Native children with chronic lung conditions

et al. 2016

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“…[25][26][27] By using fMRI, changes in brain activation have been observed during the execution of active tasks 25 as well as during rest (eg, in the attention and default mode network, a network that is involved in processes such as self-reflection, day dreaming, and rumination). [28][29][30][31][32] Interestingly, several recent reviews have demonstrated that practicing mindfulness meditation is associated with increased neural activation in brain regions related to external attention (ie, prefrontal and anterior cingulate cortex) [33][34][35][36] and reduced connectivity in the DMN involved in internal attention. 37,38 We hypothesized that an MBI would have an effect on resting state functional connectivity in networks related to both external attention and internal attention and would reduce both objectively and subjectively assessed cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

Effects of a mindfulness‐based intervention on cancer‐related cognitive impairment: Results of a randomized controlled functional magnetic resonance imaging pilot study

Gucht

Ahmadoun

Melis

et al. 2020

Cancer

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Background Many breast cancer survivors suffer from cognitive complaints after cancer treatment, affecting their quality of life. The objective of this pilot study was to investigate the effect of a blended‐care mindfulness‐based intervention (MBI) on chemotherapy‐related cognitive impairment and functional brain changes. Furthermore, correlations between changes in cognitive functioning and self‐reported behavioral factors were investigated. Methods Breast cancer survivors (n = 33) who reported cognitive impairment were randomly allocated to a mindfulness condition (n = 18) or a waitlist control condition (n = 15). Patients completed questionnaires on cognitive impairment, emotional distress, and fatigue; neuropsychological tests; and resting‐state functional magnetic resonance imaging before the start of MBI (time 1 [T1]), immediately after the completion of an 8‐week MBI program (T2), and 3 months postintervention (T3). Resting‐state functional connectivity was estimated in the default mode network, the dorsal and salience attention networks, and the frontoparietal network. Mixed model repeated‐measures analysis was performed to test the intervention effect. Results Patients in the mindfulness condition exhibited significantly higher connectivity between the dorsal and salience attention networks after the mindfulness intervention compared with those in the control condition. MBI participants also had reduced subjective cognitive impairment, emotional distress, and fatigue. No intervention effect was observed on neurocognitive tests. Conclusions MBI may induce functional brain changes in networks related to attention and may have a positive effect on subjective measures of cognitive impairment in breast cancer survivors. Therefore, MBI could be a suitable intervention to improve quality of life in this population and deserves further study in this context.

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“…Previous studies showed that BC patients have brain structure changes after adjuvant chemotherapy, such as reduced gray matter and alterations in white matter. In addition, brain functional changes were observed in BC patients, such as decreased efficiency of functional connectivity (FC) and neural networks in a resting state ( Piccirillo et al, 2015 ; Tao et al, 2017 ), and cerebral activation alterations during the performance of cognitive tasks ( Silverman et al, 2007 ). Recently, researchers used resting-state FC to explore the neural activity of brain regions ( Fox and Raichle, 2007 ; Li et al, 2019 ; Liao et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Modulation of Interhemispheric Functional Coordination in Breast Cancer Patients Receiving Chemotherapy

et al. 2020

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Objectives: Chemotherapy induces cognitive impairments including memory impairment attention deficit and executive dysfunction in patients with breast cancer (BC) during or after chemotherapy. Previous studies identified brain structural and functional changes in BC patients receiving chemotherapy; however, there are no studies assessing functional connectivity (FC) between homotopic brain regions in BC patients using a voxel-mirrored homotopic connectivity (VMHC) method. In the present study, we explored cognitive function and whole brain homotopic FC in BC patients receiving chemotherapy compared with healthy controls using the VMHC method. Methods: The present cross-sectional study included 35 premenopausal women with breast cancer who received chemotherapy, as well as 32 age-and sex-matched healthy controls (HC). All subjects underwent resting-state functional magnetic resonance imaging, which measured homotopic brain FC, and cognitive neuropsychological assessments evaluating attention, memory, and executive function domains. Results: The BC group had lower VMHC than the HC group in the cingulated posterior, insular and postcentral regions. No region exhibited higher VMHC in the BC group than in HC group. Correlation analysis in the BC group indicated that VMHC values in the cingulated posterior were significantly correlated with executive function tests, and that the VMHC values in the insular were significantly correlated with memory tests. Conclusion: The present study showed that VMHC decreased in different brain regions including cingulated posterior, insular and postcentral regions. A significant correlation was observed between the VMHC values in the brain regions and neuropsychological tests. These results suggested that changes in VMHC values in different brain regions may underlie cognitive changes in BC patients receiving chemotherapy.

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Impairment of the executive function in breast cancer patients receiving chemotherapy treatment: a functional MRI study

Cited by 37 publications

References 55 publications

Housing characteristics and indoor air quality in households of Alaska Native children with chronic lung conditions

Housing characteristics and indoor air quality in households of Alaska Native children with chronic lung conditions

Effects of a mindfulness‐based intervention on cancer‐related cognitive impairment: Results of a randomized controlled functional magnetic resonance imaging pilot study

Modulation of Interhemispheric Functional Coordination in Breast Cancer Patients Receiving Chemotherapy

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