Impaired Vitamin D Metabolism in Hospitalized COVID-19 Patients

Povaliaeva, Alexandra; Bogdanov, Viktor; Pigarova, Ekaterina; Dzeranova, Larisa; Katamadze, Nino; Малышева, Н. М.; Ioutsi, Vitaliy; Nikankina, Larisa; Rozhinskaya, Liudmila; Mokrysheva, Natalia

doi:10.3390/ph15080906

Cited by 11 publications

(11 citation statements)

References 67 publications

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“…Vitamin D depletion is common in severely ill COVID-19 patients [7]. The connection between abnormal kidney function, abnormal vitamin D metabolism, and hypophosphatemia has been demonstrated in a recent study done by Povaliaeva et al [35]. The authors indicated that patients with severe COVID-19 had abnormal vitamin D metabolism, higher serum creatinine levels, and lower serum phosphate levels [35].…”

Section: Discussionmentioning

confidence: 98%

Hypophosphatemia in Coronavirus Disease 2019 (COVID-19), Complications, and Considerations: A Systematic Review

Fakhrolmobasheri

Vakhshoori

Heidarpour

et al. 2022

BioMed Research International

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Coronavirus disease 2019 (COVID-19) has various manifestations on different body organs, including the lungs, heart, kidneys, and central nervous system. However, the frequency of electrolyte abnormalities, especially hypophosphatemia, is still debated in this pandemic. Our main aim in this review is to evaluate the frequency and complications of hypophosphatemia in COVID-19-infected individuals. A systematic literature review was performed in Web of Science, Scopus, PubMed, EMBASE, and Cochrane electronic databases with the combination of different keywords till October 2021. We recruited all relevant published records (including cross-sectional and case-control studies as well as editorials and brief reports) assessing hypophosphatemia among patients with COVID-19 infection. After assessing all 928 recruited records and discarding duplicates, 4 records met the inclusion criteria. Three articles were further included during a manual search of the literature. Overall, the included studies reported 1757 subjects (males: 51.3%), with the mean age ranging from 37.2 ± 13.6 years to 65.9 ± 13.9 years. Hypophosphatemia prevalence has been reported from 7.6% to 19.5%. Patients with the severe status of COVID-19 had a higher prevalence of low serum phosphate levels than those with moderate infection. This review indicates that hypophosphatemia might be categorized as a complication in clinical settings during the COVID-19 pandemic, requiring a high clinical suspicion to implement appropriate diagnostic and therapeutic interventions to prevent life-threatening outcomes. However, it needs to be more elucidated by further studies whether hypophosphatemia in severe COVID-19 is directly related to COVID-19 or is just a complication of severe illness.

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Section: Discussionmentioning

confidence: 98%

Hypophosphatemia in Coronavirus Disease 2019 (COVID-19), Complications, and Considerations: A Systematic Review

Fakhrolmobasheri

Vakhshoori

Heidarpour

et al. 2022

BioMed Research International

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“…Importantly, the study of Povaliaeva et al 22 found that severely ill covid-19 patients do not have only low levels of vitamin D but they also have profound abnormalities in the metabolism of vitamin D regardless of the clinical course of the disease. Also, the experimental study of Arora et al 23 provided evidence of the protective role of vitamin D against pulmonary viral infection.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Prognostic Significance of Baseline Serum Vitamin D Levels in Hospitalized Egyptian Covid-19 Patients

Mostafa¹,

Mohammed²,

Elshennawy³

et al. 2022

IJGM

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Background andAim: Vitamin D is a hormone with essential roles in both cellular metabolism and immunity. It controls calcium homeostasis and modulates innate and adaptive immune system responses. Many studies suggested an association between vitamin D deficiency and clinical outcomes of covid-19 infection, while others failed to document such a relation. The present study aimed to evaluate the clinical and prognostic significance of baseline vitamin D levels in hospitalized Egyptian covid-19 patients. Patients and Methods: The present retrospective study included 300 hospitalized covid-19 patients. Patients were submitted to standard clinical, laboratory, and radiological assessment. According to vitamin D levels, patients were classified to have normal levels (≥30), insufficient levels (20-29) or deficient levels (<20). Results: According to their vitamin D levels, patients were classified into those with normal vitamin D (n=135), others with vitamin D insufficiency (n=114), and a third group with vitamin D deficiency (n=51). Patients with normal vitamin D levels and vitamin D insufficiency are significantly younger [median (IQR): 49.0 (39.0-57.0) versus 51.0 (40.0-61.0) and 55.0 (43.0-62.0) years, respectively, p=0.012] and had less frequency of severe disease (24.4% versus 40.4% and 51.0%, respectively) when compared with those with vitamin D deficiency. Moreover, they had significantly lower levels of D dimer [median (IQR): 1.

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“…The prevalence of vitamin D deficiency is high among individuals with severe COVID-19 infection [ 40 ]. Povaliaeva et al recently conducted a study that established an association between abnormal kidney function, abnormal vitamin D metabolism and hypophosphatemia ( Table 1 ) [ 41 ]. According to the authors, individuals with severe COVID-19 manifested atypical vitamin D metabolism, increased serum creatinine levels and decreased serum phosphate levels ( Figure 4 ) [ 41 ].…”

Section: Incidence Of Phosphocalcium Metabolism Disorders Related To ...mentioning

confidence: 99%

“…Vitamin D (VD) has been recognized for its significant involvement in various metabolic pathways related to musculoskeletal health [ 41 ]. Previous research has demonstrated that supplementation with VD has been shown to confer advantages in muscle recovery following periods of intense physical activity and tissue damage [ 31 , 50 ].…”

Section: Incidence Of Phosphocalcium Metabolism Disorders Related To ...mentioning

confidence: 99%

Calcium, Phosphorus and Magnesium Abnormalities Associated with COVID-19 Infection, and Beyond

Anghel,

Manole,

Nechita

et al. 2023

Biomedicines

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The coronavirus disease (COVID-19) pandemic caused by the novel coronavirus SARS-CoV-2 has had a profound impact on global health, leading to a surge in research to better understand the pathophysiology of the disease. Among the various aspects under investigation, disruptions in mineral homeostasis have emerged as a critical area of interest. This review aims to provide an overview of the current evidence linking calcium, phosphorus and magnesium abnormalities with COVID-19 infection and explores the potential implications beyond the acute phase of the disease. Beyond the acute phase of COVID-19, evidence suggests a potential impact of these mineral abnormalities on long-term health outcomes. Persistent alterations in calcium, phosphorus and magnesium levels have been linked to increased cardiovascular risk, skeletal complications and metabolic disorders, warranting continuous monitoring and management in post-COVID-19 patients.

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Impaired Vitamin D Metabolism in Hospitalized COVID-19 Patients

Cited by 11 publications

References 67 publications

Hypophosphatemia in Coronavirus Disease 2019 (COVID-19), Complications, and Considerations: A Systematic Review

Hypophosphatemia in Coronavirus Disease 2019 (COVID-19), Complications, and Considerations: A Systematic Review

Clinical and Prognostic Significance of Baseline Serum Vitamin D Levels in Hospitalized Egyptian Covid-19 Patients

Calcium, Phosphorus and Magnesium Abnormalities Associated with COVID-19 Infection, and Beyond

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