Impaired NK cell functionality and increased TNF-α production as biomarkers of chronic chikungunya arthritis and rheumatoid arthritis

Thanapati, Subrat; Ganu, Mohini A.; Giri, Prashant S.; Kulkarni, Shruti P.; Sharma, Meenal; Babar, Prasad; Ganu, Ashok; Tripathy, Anuradha S.

doi:10.1016/j.humimm.2017.02.006

Cited by 56 publications

(37 citation statements)

References 30 publications

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“…In addition to soluble host factors responsible for regulating antiviral responses, CD4+ T cells have been shown to be a major driver of arthritic disease during chikungunya virus infection in mouse models and in the follow‐up of patients with chronic chikungunya arthritis . Moreover, impaired NK cell function was shown to be associated with chronic arthritis in infected patients . Importantly, Treg cells, a subset of CD4+ T cells, may play a role in moderating excessive chikungunya virus–induced immune responses.…”

Section: Chronic Stage Of Chikungunya Virus (>3 Months After the Onsementioning

confidence: 99%

Review: Chikungunya Arthritis: Implications of Acute and Chronic Inflammation Mechanisms on Disease Management

Zaid

Gérardin

Taylor

et al. 2018

Arthritis & Rheumatology

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In the past decade, arboviruses-arthropod-borne viruses-have been the focus of public health institutions worldwide following a spate of devastating outbreaks. Chikungunya virus, an arbovirus that belongs to the alphavirus genus, is a reemerging arthritogenic virus that has caused explosive outbreaks since 2006, notably on Réunion Island, and more recently in the Caribbean, South America, India, and Southeast Asia. The severity of arthritic disease caused by chikungunya virus has prompted public health authorities in affected countries to develop specific guidelines to tackle this pathogen. Chikungunya virus disease manifests first as an acute stage of severe joint inflammation and febrile illness, which later progresses to a chronic stage, during which patients may experience debilitating and persisting articular pain for extended periods. This review aims to provide a broad perspective on current knowledge of chikungunya virus pathogenesis by identifying key clinical and experimental studies that have contributed to our understanding of chikungunya virus to date. In addition, the review explores the practical aspects of treatment and management of both acute and chronic chikungunya virus based on clinical experience during chikungunya virus outbreaks. Finally, recent findings on potential therapeutic solutions-from antiviral agents to immunomodulators-are reviewed to provide both viral immunologists and clinical rheumatologists with a balanced perspective on the nature of a reemerging arboviral disease of significant public health concern, and insight into future therapeutic approaches to better address the treatment and management of chikungunya virus.

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Section: Chronic Stage Of Chikungunya Virus (>3 Months After the Onsementioning

confidence: 99%

Review: Chikungunya Arthritis: Implications of Acute and Chronic Inflammation Mechanisms on Disease Management

Zaid

Gérardin

Taylor

et al. 2018

Arthritis & Rheumatology

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“…ICAM-1 is an adhesion molecule that allows cells to connect to other cells or to extracellular matrix molecules and plays an important role in inflammatory processes [31]. These factors are known to increase during inflammatory or apoptotic diseases, such as myocarditis, rheumatoid arthritis, diabetes, and systemic lupus erythematosus [32][33][34][35]. In the EIU model, we observed an inflammatory response in the ocular anterior segment, and these inflammatory cytokines were markedly higher than in the control group.…”

Section: Discussionmentioning

confidence: 90%

Synthetic Glucocorticoid-Induced Leucine Zipper Peptide Inhibits Lipopolysaccharide-Induced Ocular Inflammation in Rats

Guo

et al. 2019

Ophthalmic Res

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To demonstrate the anti-inflammatory action of a synthetic glucocorticoid-induced leucine zipper (GILZ 98-134) peptide (GILZ-p) in a model of endotoxin-induced uveitis (EIU) in rats. Methods: The EIU model was induced in Sprague Dawley rats with an intravitreal injection of lipopolysaccharide (LPS). Synthetic GILZ-p was injected intravitreally 6 h after the LPS injection. To evaluate the anti-inflammatory effects of GILZ-p, the inflammatory response in the anterior chamber and iris of the rat eyes was evaluated with a slitlamp microscope on days 0, 1, 2, 3, and 4 after GILZ-p injection. The retinal expression of inflammatory cytokines was measured on days 0, 1, 2, 3, and 4 after GILZ-p injection. Müller cell gliosis was also detected at planned time points after GILZ-p injection. Results: Anterior segment inflammation peaked at 24 h after LPS injection in the EIU model. Compared with the controls, intravitreal GILZ-p significantly suppressed LPS-induced anterior segment inflammation in the EIU rats. The levels of retinal inflammatory factors IL-1β, TNF-α, MCP-1, and ICAM-1 were simultaneously reduced by the intravitreal GILZ-p injection. The expression of vimentin in the EIU retina was significantly reduced by GILZ-p, and the downregulated aquaporin 4 in the EIU retina was significantly restored by GILZ-p. Conclusion: The synthetic GILZ-p inhibited the inflammatory reaction in the EIU model and may have utility in the treatment of inflammatory ocular disease.

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“…Exclusion criteria for this group were presence of RA factor [Rheumatoid factor, which is a set of heterogenous immunoglobins produced in an individual suffering from rheumatoid arthritis(RA)], anti‐cyclic citrullinated peptide (CCP) antibody, anti‐nuclear antibody (ANA) positivity and raised serum uric acid levels, to exclude similar looking illnesses. (b) Chronic chikungunya patients: chronic persistent inflammatory polyarthritis/arthralgias lasting for more than 3 months after an episode of acute febrile polyarthritis and positive for chikungunya IgM/IgG antibodies . Exclusion criteria for this group were the presence of RA factor, anti‐CCP antibody, ANA positivity, and raised serum uric acid levels.…”

Section: Methodsmentioning

confidence: 99%

Association of IL1RN VNTR polymorphism with chikungunya infection: A study from Western India

Tripathy

Ganu

Lata

et al. 2019

Journal of Medical Virology

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Chikungunya, caused by the chikungunya virus (CHIKV) mostly presents as acute and chronic articular inflammatory manifestations. Interleukin 1 receptor antagonist (IL-1RN) is a potent endogenous competitive inhibitor of IL-1α and 1β and has an antiinflammatory role. The present study evaluated the possible association of IL1RN variable number tandem-repeat (VNTR) alleles and genotypes, and CHIKV stimulated IL-1RN cytokine production with resistance and/or susceptibility to chikungunya infection and disease state in 224 patients with chikungunya (61 patients with acute chikungunya and 163 patients with chronic chikungunya) and 355 healthy controls.Polymerase chain reaction, CHIKV stimulated cytokine assay and luminex platform were used for assessing polymorphism and protein levels respectively. The study revealed a significant association of IL1RN*1/*1 genotype under recessive genetic model with the risk of developing chikungunya infection. Our findings also indicated that IL1RN *2 allele under dominant mode was associated with protection to chronic chikungunya. The results also revealed a higher production of IL-1 RN protein in patients with chronic chikungunya. To conclude, the results suggest the association of ILRN VNTR polymorphism and IL-RN protein levels with chronic chikungunya.

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Impaired NK cell functionality and increased TNF-α production as biomarkers of chronic chikungunya arthritis and rheumatoid arthritis

Cited by 56 publications

References 30 publications

Review: Chikungunya Arthritis: Implications of Acute and Chronic Inflammation Mechanisms on Disease Management

Review: Chikungunya Arthritis: Implications of Acute and Chronic Inflammation Mechanisms on Disease Management

Synthetic Glucocorticoid-Induced Leucine Zipper Peptide Inhibits Lipopolysaccharide-Induced Ocular Inflammation in Rats

Association of IL1RN VNTR polymorphism with chikungunya infection: A study from Western India

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