volume 29, issue 4, P783-791 2012
DOI: 10.3233/jad-2012-111880
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Li-Min Chua, Mei-Li Lim, Pey-Rou Chong, Ze Ping Hu, Nam Sang Cheung, Boon-Seng Wong

Abstract: Reduced glucose utilization is likely to precede the onset of cognitive deficits in Alzheimer's disease (AD). Similar aberrant glucose metabolism can also be detected in the brain of several AD mouse models. Although the cause of this metabolic defect is not well understood, it could be related to impaired insulin signaling that is increasingly being reported in AD brain. However, the temporal relationship between insulin impairment and amyloid-β (Aβ) biogenesis is unclear. In this study using female AβPPsw/PS…

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