1999
DOI: 10.1046/j.1365-2125.1999.00915.x
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Abstract: Aims We investigated whether venoconstriction by a-adrenoceptor stimulation, and venodilation by b-adrenoceptor stimulation and nitroglycerin are altered in patients with diabetes mellitus (DM). Methods Eight male patients with non insulin-dependent DM and eight agematched control subjects were included. The patients had neither hypertension nor hyperlipidaemia. Noradrenaline (1 to 512 ng min Conclusions These data suggested that venoconstriction by a-adrenoceptor stimulation and venodilation by nitroglycerin … Show more

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Cited by 9 publications
(4 citation statements)
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References 21 publications
(34 reference statements)
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“…Impaired β-adrenoceptor-mediated vasodilation has been shown recently in mesenteric arteries of obese Zucker rats [3] and in peripheral veins of patients with type 2 diabetes mellitus [11]. In this regard, the present data on coronary arteries add novel information to further understand metabolic syndrome-associated vascular dysfunction in general and coronary dysfunction in particular.…”
Section: Discussionmentioning
confidence: 88%
“…Impaired β-adrenoceptor-mediated vasodilation has been shown recently in mesenteric arteries of obese Zucker rats [3] and in peripheral veins of patients with type 2 diabetes mellitus [11]. In this regard, the present data on coronary arteries add novel information to further understand metabolic syndrome-associated vascular dysfunction in general and coronary dysfunction in particular.…”
Section: Discussionmentioning
confidence: 88%
“…b-Adrenoceptor-mediated vasodilatation is impaired in diseases such as hypertension and type 2 diabetes (Naslund et al, 1990;Harada et al, 1999;Chen and Doggrell, 2002;Grisk et al, 2007). As ERK activity is enhanced in vascular smooth muscle in these diseases (Touyz et al, 2002;Kim et al, 2005;Matsumoto et al, 2006), the data presented here open up the possibility that the impairment of b-adrenoceptor function is due in part to the increased ERK activity.…”
Section: Discussionmentioning
confidence: 65%
“…β‐Adrenoceptor‐mediated vasodilatation is impaired in diseases such as hypertension and type 2 diabetes (Naslund et al. , 1990; Harada et al. , 1999; Chen and Doggrell, 2002; Grisk et al.…”
Section: Discussionmentioning
confidence: 99%
“…These findings are consistent with the previous studies (4-6) using the dorsal hand vein method. By contrast, the β-adrenoceptor-mediated venodilating effect in HT or DM patients is reported to be reduced as compared with that in control subjects (7,8), and it is also reduced by aging (5).…”
Section: Discussionmentioning
confidence: 85%