Impaired β‐adrenoceptor mediated venodilation in patients with diabetes mellitus

Abstract

Aims We investigated whether venoconstriction by a-adrenoceptor stimulation, and venodilation by b-adrenoceptor stimulation and nitroglycerin are altered in patients with diabetes mellitus (DM). Methods Eight male patients with non insulin-dependent DM and eight agematched control subjects were included. The patients had neither hypertension nor hyperlipidaemia. Noradrenaline (1 to 512 ng min Conclusions These data suggested that venoconstriction by a-adrenoceptor stimulation and venodilation by nitroglycerin are not altered, whereas venodilation by b-adrenoceptor stimulation might be impaired in patients with DM.Keywords: diabetes mellitus, vein, vascular response, a-and b-adrenoceptors, nitroglycerin important to investigate the functions of both a-and Introduction b-adrenoceptors in blood vessels in DM.In the present study, we examined, using a dorsal hand Diabetes mellitus (DM) is a prevalent disease often associated with vascular complications, such as microvein technique [8], the vasoconstrictor response to noradrenaline, an a-adrenoceptor agonist, and vasodilator angiopathy and atherosclerosis. Although the mechanisms of vascular dysfunction in DM are poorly understood, responses to isoprenaline, a b-adrenoceptor agonist, and nitroglycerin in DM patients and control subjects. several reports [1][2][3][4][5] have provided data suggesting alternations in vascular responses to vasoactive agents. Based on the findings obtained from studies of diabetic Methods animals [1, 2] and humans [3, 4], it is suggested that endothelium-dependent vasodilation is impaired in DM. Subjects However, whether vasodilator response to nitrates and Eight male DM patients and eight male control subjects vasoconstrictor response to a-adrenoceptor agonists are who were not hypertensive and had normal serum altered in DM is controversial [1-5]. Furthermore, to cholesterol level were included in this study (Table 1). our knowledge, it is unknown whether vasodilation They did not take any medications except for hypoglyinduced by b-adrenoceptor stimulation is impaired in DM.cemic drugs for at least 7 days before the study. There As the sympathetic nervous system plays an important were three smokers in each group, but they did not role in the regulation of systemic circulation and is smoke for at least 24 h before the study. All the patients involved in the onset of cardiovascular events [6, 7], it is had non-insulin-dependent DM (NIDDM) with the history of 6 to 17 (mean 10) years, and six of them had and/or voglibose (0.4-0.6 mg day −1 ), an a-glucosidase

Impaired coronary function in Wistar Ottawa Karlsburg W rats—a new model of the metabolic syndrome

“…Impaired β-adrenoceptor-mediated vasodilation has been shown recently in mesenteric arteries of obese Zucker rats [3] and in peripheral veins of patients with type 2 diabetes mellitus [11]. In this regard, the present data on coronary arteries add novel information to further understand metabolic syndrome-associated vascular dysfunction in general and coronary dysfunction in particular.…”

Effect of inhibition of extracellular signal‐regulated kinase on relaxations to β‐adrenoceptor agonists in porcine isolated blood vessels

“…b-Adrenoceptor-mediated vasodilatation is impaired in diseases such as hypertension and type 2 diabetes (Naslund et al, 1990;Harada et al, 1999;Chen and Doggrell, 2002;Grisk et al, 2007). As ERK activity is enhanced in vascular smooth muscle in these diseases (Touyz et al, 2002;Kim et al, 2005;Matsumoto et al, 2006), the data presented here open up the possibility that the impairment of b-adrenoceptor function is due in part to the increased ERK activity.…”

“…β‐Adrenoceptor‐mediated vasodilatation is impaired in diseases such as hypertension and type 2 diabetes (Naslund et al. , 1990; Harada et al. , 1999; Chen and Doggrell, 2002; Grisk et al.…”

Vasoconstricting Effect of Angiotensin II in Human Hand Veins: Influence of Aging, Diabetes Mellitus and Hypertension.

“…These findings are consistent with the previous studies (4-6) using the dorsal hand vein method. By contrast, the β-adrenoceptor-mediated venodilating effect in HT or DM patients is reported to be reduced as compared with that in control subjects (7,8), and it is also reduced by aging (5).…”