volume 28, issue 4, P765-769 2012
DOI: 10.3233/jad-2011-111502
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Abstract: Preclinical diagnosis of Alzheimer's disease is a major challenge. The present study evaluates glutamatergic and GABAergic neurotransmitter energetics at the age of 6 months in AβPPswe-PS1dE9 mouse model of Alzheimer's disease by using (1)H-[(13)C]-NMR spectroscopy together with infusion of [1,6-(13)C(2)]glucose. NMR analysis suggested no significant derangement in neurochemical profile in AβPPswe-PS1dE9 mice. However, decrease in labeling of glutamate-C4, GABA-C2 and glutamine-C4 at early infusion-time togeth…

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