Impaired gastric motility and its relationship to reflux symptoms in patients with nonerosive gastroesophageal reflux disease

Kamiya, Tetsuro; Adachi, Hiroshi; Hirako, Makoto; Shikano, Michiko; Matsuhisa, Eriko; Wada, Takeshi; Ogasawara, Nagahisa; Nojiri, Shunsuke; Kataoka, Hiromi; Sasaki, Makoto; Ohara, Hirotaka; Joh, Takashi

doi:10.1007/s00535-008-2289-z

Cited by 36 publications

(29 citation statements)

References 37 publications

(32 reference statements)

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“…All these clinical and basic data suggest the possibility that rikkunshito relieves the symptoms of PPI-refractory GERD patients, especially those with NERD, via attenuation of the motility dysfunction around the esophagogastric junction. On the basis of this consideration, some studies have been conducted to verify the usefulness of prokinetic agents such as mosapride, which promotes acetylcholine secretion via the stimulation of serotonin type 4 receptors, and itopride, which has antagonistic actions on dopamine D2 receptors, for PPI-refractory NERD patients [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan

et al. 2011

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“…Another possible mechanism is that gastric emptying is delayed, and dyspepsia is common in diabetic patients [43]. Gastric hypomotility appears to be an important factor in reflux symptom generation, thereby leading to Barrett's esophagus and adenocarcinoma [44]. Furthermore, most of diabetic individuals were overweight or obese.…”

Section: Discussionmentioning

confidence: 99%

Risk of esophageal cancer in diabetes mellitus: a meta-analysis of observational studies

Huang

Ren

Ben

et al. 2011

Cancer Causes Control

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“…If there is an interaction between delayed gastric emptying and GERD symptoms, prokinetic agents may improve GERD symptoms by resolving delayed gastric emptying. Kamiya et al [26] reported that the symptoms response rates to treatment with mosapride is higher in nonerosive reflux disease (NERD) patients with delayed gastric emptying than in NERD patients with normal gastric emptying. Their result is compatible with our present study.…”

Section: Discussionmentioning

confidence: 99%

Gender Difference of Gastric Emptying in Healthy Volunteers and Patients with Functional Dyspepsia

Mori¹,

Suzuki

Matsuzaki³

et al. 2017

Digestion

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Background and Aim: Delayed gastric emptying is one of the reasons why functional dyspepsia (FD) occurs. The ¹³C-acetate breath test is widely used to evaluate gastric emptying. Nevertheless, the standard value of ¹³C-acetate breath test has not taken into account the gender difference of gastric emptying among healthy individuals. The main aim of this study was to readjust the standard value of ¹³C-acetate breath test in the light of gender differences. In addition, we clarified the prevalence and clinical characteristics of delayed gastric emptying in patients with FD using the modified standard values of ¹³C-acetate breath test. Methods: Fifty-two healthy individuals and 126 patients with patients with FD were enrolled. Gastric emptying was evaluated by the ¹³C-acetate breath test. The cut-off points of T_max for the diagnosis of delayed gastric emptying were determined on the basis of results from healthy individuals making a distinction of genders. Gastroesophageal reflux symptoms, dyspeptic symptoms, scores of anxiety and depression, age, body mass index (BMI), smoking and alcohol consumption were compared between the delayed gastric emptying group and the non-delayed gastric emptying group. Results: Since gastric emptying was delayed in healthy women compared with that in healthy men (T_max, 53.6 ± 19.3 vs. 42.7 ± 16.9 min, p = 0.04), we set the cut-off points of T_max at 60 min in men and at 75 min in women. In patients with FD, the prevalence of delayed gastric emptying was not different between men and women with the modified standard values of ¹³C-acetate breath test. (31.0 vs. 27.4%, p = 0.68). BMI was lower in the delayed gastric emptying group than in the non-delayed group among the male patients. Reflux symptoms were more severe in delayed gastric emptying group than in the non-delayed group among the female patients. Conclusion: The standard values of ¹³C-acetate breath test should be modified bearing the gender difference in mind. It provides us more appropriate information to understand the mechanisms of FD.

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Impaired gastric motility and its relationship to reflux symptoms in patients with nonerosive gastroesophageal reflux disease

Abstract: Gastric hypomotility appears to be an important factor in reflux symptom generation in some NERD patients.

Cited by 36 publications

References 37 publications

Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan

Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan

Risk of esophageal cancer in diabetes mellitus: a meta-analysis of observational studies

Gender Difference of Gastric Emptying in Healthy Volunteers and Patients with Functional Dyspepsia

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