Impaired Fibrinolytic Capacity Predisposes for Recurrence of Venous Thrombosis

Abstract

SummaryThe fibrinolytic capacity of 121 patients with a history of venous thrombosis and/or pulmonary embolism was studied by venous occlusion technique, at earliest 3 months after the last thromboembolic episode. After discontinuation of oral anticoagulation treatment the clinical course of the patients was followed and new thromboembolic episodes were noted. During the observation period of 56 ± 18.8 months 45 of 121 patients experienced recurrence of thrombosis. The recurrence-rate was significantly lower in patients with a post-occlusion ELT shorter than 60 min (4.8%/year) than in patients with an ELT longer than 60 min (10.3%/year). It is concluded that the fibrinolytic capacity is a useful parameter for determining the risk of recurrence in patients with venous thrombosis.

Thrombophilia in ethnic Arabs in Kuwait

“…The significance of hypofibrinolysis as a possible risk factor for venous and arterial thrombosis has been critically reviewed in several publications [3,4,[32][33][34][35][36][37].…”

“…Some of these publications are based on descriptive case studies and family studies [3,35]. The prevalence of impaired fibrinolytic activity among patients with recurrent venous and arterial thrombosis ranged from 7 to 37% in these studies [3,4,34,35,37].…”

The Incidence of Recurrent Venous Thromboembolism After Treatment With Vitamin K Antagonists in Relation to Time Since First Event

“…Of the remaining 118 studies, 1,2,8-123 100 had to be excluded. The reasons for exclusion were absence of data on timing of the recurrent events (83 studies), 1,2, reports on the same cohort (9 studies), [89][90][91][92][93][94][95][96][97] loss to follow-up exceeding 10% (4 studies), [97][98][99][100][101] lack of confirmation of diagnosis by objective diagnostic methods (3 studies), [102][103][104] and concomitant use of antiplatelet or other anticoagulant drug (1 study). 105 Therefore, a total of 18 studies were available for data extraction, [106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122][123] some of which used prothrombin time, or Thrombotest, 124 to estimate international normalized ratio.…”

Fibrinolytic Activity of Blood and its Determinants in Healthy Medical Students

“…This is found to be well correlated with proneness towards stroke, IHD, thrombo-embolic diseases and is an independent predictor of both fatal and nonfatal IHD [4][5][6]. Thus assessment of fibrinolysis time is one of the most important markers of cardiovascular health [7].…”