Impaired coronary microvascular function in familial Mediterranean fever

Çalışkan, Mustafa; Güllü, Hakan; Yılmaz, Sema; Erdoğan, Doğan; Unler, Gulhan Kanat; Çiftçi, Özgür; Topçu, Semra; Kayhan, Zeynep; Yücel, Eftal; Müderrisoğlu, Haldun

doi:10.1016/j.atherosclerosis.2007.06.014

Cited by 62 publications

(50 citation statements)

References 25 publications

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“…Additionally, a few previous studies have shown that FMF was associated with increased atherosclerosis risk (17)(18)(19). However, according to the results of this study, MPV changes in FMF patients might not be a predisposing factor for increased atherosclerosis at least in pediatric age group.…”

Section: Discussioncontrasting

confidence: 33%

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Mean Platelet Volume in Children with Familial Mediterranean Fever and the Relationship with Attack Status, Colchicine Treatment and Gene Mutation

et al. 2014

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Section: Discussioncontrasting

confidence: 33%

“…The increase in atherosclerosis risk in FMF patients was reported in a few recent studies (17)(18)(19). However, there are a few studies investigating MPV levels in FMF patients (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Mean Platelet Volume in Children with Familial Mediterranean Fever and the Relationship with Attack Status, Colchicine Treatment and Gene Mutation

et al. 2014

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“…During attack-free periods, patients with FMF may still experience arthritis, myalgia, autonomic dysregulation with altered cardiovascular reactivity [30] and other cardiovascular symptoms related to persistent subclinical inflammation [18]. Importantly, recent studies with cardiovascular imaging techniques identified signs of diastolic dysfunction and microvascular coronary pathology which were correlated with elevated levels of CRP during attack-free period [31,32]. Clinical significance of coronary pathology in FMF was also highlighted in a few previous reports of coronary vasculitis, transient left bundle branch block and MI associated with inflammation in FMF [33][34][35].…”

Section: Fmf As a Low-grade Inflammatory Disordermentioning

confidence: 99%

Familial Mediterranean Fever as an Emerging Clinical Model of Atherogenesis Associated with Low-Grade Inflammation

Yüksel¹,

Ayvazyan²,

Gasparyan³

2010

TOCMJ

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Numerous inflammatory and innate immune pathways are involved in atherogenesis. Elaboration of clinical models of inflammation-induced atherogenesis may further advance our knowledge of multiple inflammatory pathways implicated in atherogenesis and provide a useful tool for cardiovascular prevention. Familial Mediterranean fever (FMF) is a chronic inflammatory disorder with profiles of inflammatory markers close to that seen in the general population. In a few recent studies, it has been shown that endothelial dysfunction, increased atherosclerotic burden and activation of platelets accompany attack-free periods of FMF. Colchicine is proved to be useful in suppression of inflammation in FMF. Preliminary basic and clinical studies suggest that this relatively safe drug may be useful for cardiovascular protection in patients with FMF and in the general population. Multinational prospective studies are warranted to further elaborate clinical model of inflammation-induced atherosclerosis associated with FMF.

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“…[1][2][3] Inflammation may play an important role in the initiation and progression of atherosclerosis and ischemic cardiac disease. [4][5][6] Various clinical and subclinical cardiovascular involvements have been reported in FMF patients. 4,5,7 Patients with inflammatory diseases are now considered to have an increased risk of atherosclerotic cardiovascular complications.…”

mentioning

confidence: 99%

“…[4][5][6] Various clinical and subclinical cardiovascular involvements have been reported in FMF patients. 4,5,7 Patients with inflammatory diseases are now considered to have an increased risk of atherosclerotic cardiovascular complications. 8 Cardiac repolarization abnormalities may be seen due to cardiac involvement in FMF.…”

mentioning

confidence: 99%

QT and JT Dispersion in Children With Familial Mediterranean Fever

et al. 2015

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Objectives: This study aims to determine QT dispersion and JT dispersion, and their relationship with conventional echocardiography values in a group of children with familial Mediterranean fever (FMF). Patients and methods:The study included 48 FMF patients (26 males, 22 females, mean age 11.10±3.42 years; range 5 to 18 years) as the FMF patients and 31 healthy children (17 males, 14 females, mean age 9.61±2.83 years; range 5 to 17 years) as the healthy controls. Electrocardiography and conventional echocardiography were performed on the FMF patients and healthy controls. Both groups were evaluated with a standard 12-lead electrocardiography. QT, JT and RR distances were measured in both groups. The corrected QT (QTc) and corrected JT (JTc) were calculated. QTcd and corrected JT dispersion (JTcd) were detected. Results: There was no statistically significant difference between the FMF patients and healthy controls in terms of RR, QT, QTd, QTcd, JT, JTc, JTd, and JTcd measurements and echocardiography parameters. QTc value was higher in the FMF patients than the healthy controls. Conclusion: QTc value indicates increased ventricular sensitivity and is an important marker of cardiovascular mortality. It has an important effect on sudden cardiac death and arrhythmia. Our study results suggest that electrocardiographic monitoring may be useful in patients with FMF.

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Impaired coronary microvascular function in familial Mediterranean fever

Cited by 62 publications

References 25 publications

Mean Platelet Volume in Children with Familial Mediterranean Fever and the Relationship with Attack Status, Colchicine Treatment and Gene Mutation

Mean Platelet Volume in Children with Familial Mediterranean Fever and the Relationship with Attack Status, Colchicine Treatment and Gene Mutation

Familial Mediterranean Fever as an Emerging Clinical Model of Atherogenesis Associated with Low-Grade Inflammation

QT and JT Dispersion in Children With Familial Mediterranean Fever

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