Impaired Adipogenesis and Insulin Resistance in Epicardial Fat-Mesenchymal Cells From Patients With Cardiovascular Disease

Fernández-Trasancos, Ángel; Fandiño-Vaquero, Rubén; Agra, Rosa M.; Fernández, Ángel L.; Viñuela, Juan E.; González-Juanatey, José Ramón; Eiras, Sonia

doi:10.1002/jcp.24619

Cited by 25 publications

(30 citation statements)

References 39 publications

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“…An interesting result of our study is the significant correlation between EAT and HOMA-IR, consistent with the reported data in adults (53,54) and in contrast with the results of those few pediatric studies available (50,55). In pediatric cohorts, despite not finding an association between EAT and HOMA-IR, EAT was able to identify patients with insulin resistance (19,51).…”

Section: Eat Evaluationsupporting

confidence: 91%

Precocious Preclinical Cardiovascular Sonographic Markers in Metabolically Healthy and Unhealthy Childhood Obesity

et al. 2020

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Background: Childhood obesity is related to a wide spectrum of cardiovascular and metabolic comorbidities.Objectives: (1) To identify precocious, preclinical, cardiovascular sonographic modifications, in a cohort of overweight (OW) and obese (OB) children and adolescents compared to lean controls; (2) to investigate the association between clinical and metabolic variables and cardiovascular sonographic parameters; (3) to evaluate their relation with two different phenotypes of obesity: metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO). Materials and Methods:Fifty-nine OW and OB children and adolescents (9.8 ± 2.9 years) and 20 matched lean controls underwent anthropometric, biochemical, echocardiography assessment, and sonographic evaluation of carotid artery and ascending aorta (AA). OW and OB subjects were divided in MHO and MUO, according to the Camhi et al. definition.Results: OW and OB children showed significantly higher left ventricular (LV) dimensions and mass, carotid artery intima-media thickness (CIMT), carotid stiffness [β-index, pulse wave velocity (PWV)], significantly lower mitral peak early (E) and late (A) velocity ratio (E/A ratio), and significantly impaired global longitudinal strain (GLS) compared to controls. BMI SD and HOMA-IR were positively significantly related to LV dimensions, LA volume and epicardial adipose tissue (EAT), and negative to E/A ratio. Waist circumference (WC) was positively correlated to LV dimensions, LA volume, CIMT, PWV, AA diameter, and EAT. Furthermore, WC was a strong predictor of LV dimensions, LA volume and strain, AA stiffness and diameter; BMI SD was significantly associated with EAT, LVM index, and E/A ratio; HOMA-IR and triglycerides were significant predictors of GLS. MUO patients showed higher BMI SD (p = 0.02), WC (p = 0.001), WHtR (p = 0.001), HOMA-IR (p = 0.004), triglycerides (p = 0.01), SBP (p = 0.001), as well as LV dimensions, EAT (p = 0.03), CIMT (p = 0.01), AA diameter (p = 0.02), β-index (p = 0.03) and PWV (p = 0.002), AA stiffness (p = 0.006), and significantly impaired GLS (p = 0.042) compared to MHO.Corica et al. Cardiovascular Sonographic Markers in Childhood ObesityConclusions: Severity of overweight, abdominal obesity, insulin resistance, and MUO phenotype negatively affect cardiovascular remodeling and subclinical myocardial dysfunction in OW and OB children. MUO phenotype is likely to increase the risk of developing cardiometabolic complications since the pediatric age. Distinction between MHO and MUO phenotypes might be useful in planning a personalized follow-up approach in obese children.

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Section: Eat Evaluationsupporting

confidence: 91%

Precocious Preclinical Cardiovascular Sonographic Markers in Metabolically Healthy and Unhealthy Childhood Obesity

et al. 2020

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“…Previous studies found that pericardial fat is associated with atrial conduction [24,25] and EAT is associated with blood pressure levels [26], AF [27] and cardiovascular disease [18,20,28,29]. Van Gaal et al showed that EAT is a biologically active organ that may play a role in the association between obesity and CAD [30].…”

Section: Discussionmentioning

confidence: 99%

Increased epicardial adipose tissue volume is associated with PR interval prolongation

Hung¹,

Tang²,

Wang³

et al. 2015

CIM

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Increased epicardial adipose tissue volume is associated with PR interval prolongationAbstract Purpose: Epicardial fat is visceral adipose tissue that possesses inflammatory properties. Inflammation and obesity are associated with cardiovascular disease and arrhythmogenesis, but little is known about the relationship between epicardial fat and PR-Interval prolongation. The purpose of this study was to investigate the association between epicardial adipose tissue (EAT) volume and PR-interval prolongation as assessed by computed tomography (CT) and Twelve-lead ECGs.Methods: Patients (n=287) were referred for 64-slice CT for exclusion of coronary artery disease and EAT volumes were determined. Twelve-lead ECGs were obtained from each subject and were evaluated by two independent readers.Results: Patients with significant PR interval prolongation had higher median EAT volume than patients with normal PR interval. Statistically significant correlations were observed between the EAT volume and the PR interval (p = 0.183, p = 0.003), and QRS duration (p = 0.144, p = 0.018). Multivariate and trend analyses confirmed that EAT volume was independently associated with the presence of PR interval prolongation. The receiver operator characteristics curve of EAT volume showed that an EAT volume >144.4 cm 3 was associated with PR interval prolongation.Conclusion: This study indicates that EAT volume is highly associated with PR interval prolongation. Whether epicardial fat plays a role in the pathogenesis of PR interval prolongation requires future investigation.

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“…(1) demuestra que existe una fuerte asociación entre el tejido adiposo abdominal y corporal con el tejido adiposo epicárdico medido por ecocardiografía en mujeres posmenopáusicas. Se ha observado que la grasa epicárdica de las mujeres produce mayores concentraciones de leptina que la de los varones (5,15,16). Actualmente se está estudiando la relación de esta citocina con el riesgo cardiovascular (5,15,16), planteándose si es la precursora de la obesidad y la diabetes, así como de la disminución de la distensibilidad arterial.…”

Section: Discussionunclassified

“…Así, al igual que en otros estudios (14,16), la GV mostró una sensibilidad y una especificidad ligeramente mayor que el resto de parámetros estudiados. No obstante, en el estudio de Ozhan y cols.…”

Section: Figuraunclassified

Síndrome metabólico y grasa visceral en mujeres con un factor de riesgo cardiovascular

et al. 2017

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ResumenIntroducción: las enfermedades cardiovasculares son la primera causa de muerte en las mujeres tras la menopausia, ya que después de esta etapa se producen profundos cambios metabólicos y hormonales que favorecen el desarrollo de síndrome metabólico. Un aumento en el porcentaje de la grasa visceral puede estar relacionado con la aparición de dicho síndrome. Objetivo: establecer la relación entre la grasa visceral y los parámetros del síndrome metabólico y determinar el punto de corte óptimo para las variables relacionadas con la obesidad, en mujeres con un factor de riesgo cardiovascular. Método: estudio descriptivo transversal realizado en dos centros de salud urbanos de España. Fueron evaluadas 320 mujeres de edades comprendidas entre 45 y 60 años con hipertensión, diabetes mellitus y/o dislipemia. Se estudiaron edad, actividad estrogénica, grasa visceral y grasa corporal medida a través de un dispositivo de bioimpedancia, índice de masa corporal, perímetro abdominal, presión arterial sistólica y diastólica, triglicéridos, lipoproteínas de alta densidad, glucosa y presencia o no de síndrome metabólico. Resultados: las mujeres menopáusicas presentaban mayor cantidad de grasa visceral (p = 0,011). Se observó una correlación signifi cativa entre la grasa visceral y todos los parámetros defi nitorios del síndrome metabólico (p < 0,05). El punto de corte óptimo para las variables relacionadas con la obesidad fue: grasa visceral (8 kg), perímetro abdominal (93,5 cm), índice de masa corporal (26,9 kg/m 2 ) y grasa corporal total (24,3 kg). Conclusiones: mostraron mayor cantidad de grasa visceral las mujeres menopáusicas. Se observa una asociación entre la grasa visceral y los parámetros que defi nen el síndrome metabólico. Sería recomendable realizar un estudio más complejo que estudiase la utilidad de la grasa visceral como posible parámetro de cribado en el síndrome metabólico. Key words:Menopause. Metabolic syndrome. Intraabdominal fat. Women. AbstractIntroduction: Cardiovascular diseases are the leading cause of death in women after menopause, since after this stage there are profound metabolic and hormonal changes which favor the development of metabolic syndrome. An increase in the percentage of visceral fat may be related to the onset of this syndrome. Objective: To establish the relationship between visceral fat and parameters of the metabolic syndrome and to determine the optimal cut-off point for the variables related to obesity in women with a cardiovascular risk factor. Method: Cross-sectional descriptive study carried out in two urban health centers in Spain. We evaluated 320 women aged 45 to 60 years with hypertension, diabetes mellitus and/or dyslipidemia. Age, estrogenic activity, visceral fat and body fat measured through a bioimpedance device, body mass index, abdominal perimeter, systolic and diastolic blood pressure, triglycerides, high density lipoprotein, glucose and the presence or absence of syndrome metabolic were considered. Results: There is a signifi cant correlation between visceral...

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Impaired Adipogenesis and Insulin Resistance in Epicardial Fat-Mesenchymal Cells From Patients With Cardiovascular Disease

Cited by 25 publications

References 39 publications

Precocious Preclinical Cardiovascular Sonographic Markers in Metabolically Healthy and Unhealthy Childhood Obesity

Precocious Preclinical Cardiovascular Sonographic Markers in Metabolically Healthy and Unhealthy Childhood Obesity

Increased epicardial adipose tissue volume is associated with PR interval prolongation

Síndrome metabólico y grasa visceral en mujeres con un factor de riesgo cardiovascular

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