Impacts of dietary supplementation with p-coumaric acid and indole-3-acetic acid on survival and biochemical response of honey bees treated with tau-fluvalinate

Mitton, Giulia; Szawarski, Nicolás; Mitton, Francesca María; Iglesias, Azucena; Eguaras, Martín Javier; Ruffinengo, Sergio; Maggi, Matías

doi:10.1016/j.ecoenv.2019.109917

Cited by 18 publications

(8 citation statements)

References 65 publications

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“…The role of dietary phytochemicals in honeybees’ sensitivity to pesticide exposure cannot be overstated. The dietary supplementation with p -coumaric and indole-3-acetic acids (20 μM) enhanced the survival of bees exposed to tau-fluvalinate (~20%) [ 157 ]. Abscisic acid (ABA), a natural component found in nectar, honey, pollen, and honeybees, is critical for bees’ health.…”

Section: Strategies To Enhance Honeybee Immunitymentioning

confidence: 99%

Bee Stressors from an Immunological Perspective and Strategies to Improve Bee Health

El-Seedi

Ahmed

El-Wahed

et al. 2022

Veterinary Sciences

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Honeybees are the most prevalent insect pollinator species; they pollinate a wide range of crops. Colony collapse disorder (CCD), which is caused by a variety of biotic and abiotic factors, incurs high economic/ecological loss. Despite extensive research to identify and study the various ecological stressors such as microbial infections, exposure to pesticides, loss of habitat, and improper beekeeping practices that are claimed to cause these declines, the deep understanding of the observed losses of these important insects is still missing. Honeybees have an innate immune system, which includes physical barriers and cellular and humeral responses to defend against pathogens and parasites. Exposure to various stressors may affect this system and the health of individual bees and colonies. This review summarizes and discusses the composition of the honeybee immune system and the consequences of exposure to stressors, individually or in combinations, on honeybee immune competence. In addition, we discuss the relationship between bee nutrition and immunity. Nutrition and phytochemicals were highlighted as the factors with a high impact on honeybee immunity.

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Section: Strategies To Enhance Honeybee Immunitymentioning

confidence: 99%

Bee Stressors from an Immunological Perspective and Strategies to Improve Bee Health

El-Seedi

Ahmed

El-Wahed

et al. 2022

Veterinary Sciences

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show abstract

“…RNA-sequencing analysis revealed that both low and high levels of quercetin in larval diets induced upregulation of multiple cytochrome P450 monooxygenases, one of the major enzyme subfamilies responsible for the metabolism of toxins in honey bees ( 24 ). Diet supplementation with p- coumaric acid increased metabolism of the acaricide coumaphos ( 25 ), and increased the survival of honey bees exposed to the insecticide tau-fluvalinate ( 26 ). Supplementation with abscisic acid increased the tolerance of honey bees to the pesticide carvacrol, and the acaricide oxalic acid ( 27 ).…”

Section: The Advantages Of Processing and Storing Nectar As Honeymentioning

confidence: 99%

The role of honey in the ecology of the hive: Nutrition, detoxification, longevity, and protection against hive pathogens

et al. 2022

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Honey is the source of energy for the European honey bee, Apis mellifera. Beyond simple nutrition and a hedge against the seasonal, geographic, and chemical unpredictability of nectar, honey has properties that protect the hive against various stresses. Enzyme-mediated detoxification during honey ripening neutralizes potentially toxic phytochemicals, and bees that consume honey have enhanced tolerance to other ingested toxins. Catalase and antioxidant phenolics protect honey bees from oxidative damage caused by reactive oxygen species, promoting their longevity. Phytochemical components of honey and microRNAs have the potential to influence developmental pathways, with diet playing a large role in honey bee caste determination. Components of honey mediate stress response and promote cold tolerance during overwintering. Honey has a suite of antimicrobial mechanisms including osmotic pressure, low water activity, low pH, hydrogen peroxide, and plant-, honey bee-, and microbiota-derived compounds such as phytochemicals and antimicrobial peptides. Certain types of honey, particularly polyfloral honeys, have been shown to inhibit important honey bee pathogens including the bacteria responsible for American and European Foulbrood, the microsporidian Nosema ceranae, and the fungi responsible for Stonebrood. Understanding the diverse functional properties of honey has far-ranging implications for honey bee and hive health and management by beekeepers.

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Section: Introductionmentioning

confidence: 99%

“…Recently, bee nutrition has surged as a key factor in bee resilience against insecticides and other environmental stressors ( Bernklau et al, 2019 ; Brodschneider and Crailsheim, 2010 ; Liao et al, 2017 ; Mao et al, 2013 ; Mitton et al, 2020 ; Negri et al, 2019 ). Specific nutrients such as caffeine, p -coumaric acid, quercetin, kaempferol and casein increase resilience against insecticides while enhancing pathogen tolerance and supporting the immune system ( Bernklau et al, 2019 ; Folly et al, 2021 ; Liao et al, 2017 ; Mao et al, 2013 ; Mitton et al, 2020 ). Interestingly, some of these secondary metabolites from plants, such as flavonoids, are also intensely studied for their potential as remedies against human neurodegenerative diseases including Parkinson's and Alzheimer's disease ( Maan et al, 2020 ; Maher, 2019 ; Pu et al, 2007 ; Sabogal-Guáqueta et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

The flavonoid rutin protects the bumble bee Bombus impatiens against cognitive impairment by imidacloprid and fipronil

Riveros

Gronenberg

2022

Journal of Experimental Biology

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The ongoing decline of bee populations and its impact on food security demands integrating multiple strategies. Sublethal impairments associated with exposure to insecticides, affecting the individual and the colony levels, have led to insecticide moratoria and bans. However, legislation alone is not sufficient and remains a temporary solution to an evolving market of insecticides. Here, we ask whether bees can be prophylactically protected against sublethal cognitive effects of two major neurotoxic insecticides, imidacloprid and fipronil, with different mechanisms of action. We evaluated the protective effect of the prophylactic administration of the flavonoid rutin, a secondary plant metabolite, present in nectar and pollen, and known for its neuroprotective properties. Following controlled or ad libitum administration of rutin, foragers of the North American bumble bee B. impatiens received oral administration of the insecticides at sublethal realistic dosages. Learning acquisition, memory retention and decision speed were evaluated using olfactory absolute conditioning of the proboscis extension response. We show that the insecticides primarily impair acquisition but not retention or speed of conditioned response. We further show that the administration of the flavonoid rutin successfully protects the bees against impairments produced by acute and chronic administration of insecticides. Our results suggest a new avenue for the protection of bees against sublethal cognitive effects of insecticides.

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Impacts of dietary supplementation with p-coumaric acid and indole-3-acetic acid on survival and biochemical response of honey bees treated with tau-fluvalinate

Cited by 18 publications

References 65 publications

Bee Stressors from an Immunological Perspective and Strategies to Improve Bee Health

Bee Stressors from an Immunological Perspective and Strategies to Improve Bee Health

The role of honey in the ecology of the hive: Nutrition, detoxification, longevity, and protection against hive pathogens

The flavonoid rutin protects the bumble bee Bombus impatiens against cognitive impairment by imidacloprid and fipronil

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