Impacts of age and sex on retinal layer thicknesses measured by spectral domain optical coherence tomography with Spectralis

Nieves-Moreno, M.; Martínez-de-la-Casa, J.M.; Morales-Fernández, Laura; Sánchez-Jean, Rubén; Sáenz-Francés, F.; García‐Feijoó, Julián

doi:10.1371/journal.pone.0194169

Cited by 74 publications

(86 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…First, the possible effect of age on the outcomes needs to be addressed. Both the pRNFL and GCL are described to decrease with age, while this appears to be less pronounced for the RNFL [40,41]. As patients and controls in our cohort were well age matched, age is unlikely to be a factor for these betweengroup analyses.…”

Section: Discussionmentioning

confidence: 65%

Optical coherence tomography shows neuroretinal thinning in myelopathy of adrenoleukodystrophy

et al. 2019

View full text Add to dashboard Cite

Background Progressive myelopathy is the main cause of disability in adrenoleukodystrophy (ALD). Development of therapies is hampered by a lack of quantitative outcome measures. In this study, we investigated whether myelopathy in ALD is associated with retinal neurodegeneration on optical coherence tomography (OCT), which could serve as a surrogate outcome measure. Methods Sixty-two patients (29 men and 33 women) and 70 age-matched and sex-matched controls (33 men and 37 women) were included in this cross-sectional study. We compared retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) and peripapillary retinal nerve fiber layer (pRNFL) thickness between ALD patients and controls. In addition, we correlated these OCT measurements with clinical parameters of severity of myelopathy. Results Patients had significantly thinner RNFL (male group, p < 0.05) and pRNFL superior and temporal quadrant [both male (p < 0.005) and female (p < 0.05) groups] compared to controls. Comparing three groups (symptomatic patients, asymptomatic patients and controls), there were significant differences in RNFL thickness (total grid and peripheral ring) in the male group (p ≤ 0.002) and in pRNFL thickness (superior and temporal quadrant) in both male (p ≤ 0.02) and the female (p ≤ 0.02) groups. Neuroretinal layer thickness correlated moderately with severity of myelopathy in men (correlation coefficients between 0.29-0.55, p < 0.02), but not in women. Conclusions These results suggest that neurodegeneration of the spinal cord in ALD is reflected in the retina of patients with ALD. Therefore, OCT could be valuable as an outcome measure for the myelopathy of ALD. Additional longitudinal studies are ongoing.

show abstract

Section: Discussionmentioning

confidence: 65%

Optical coherence tomography shows neuroretinal thinning in myelopathy of adrenoleukodystrophy

et al. 2019

View full text Add to dashboard Cite

show abstract

“…One limitation of our study is that the controls were significantly older than the ACHM population by an average of 4.03 years. Previous literature has conflicting reports of the effect age has on ONL measurements, with some reporting no significant changes, 36,37 some reporting thinning, 38 and some reporting thickening. 39,40 The controls used in this study were significantly older than the ACHM patients; however, if decreasing ONL thickness with age is assumed, then accounting for this within our study only would have further increased our significance of ONL thickness between the two groups.…”

Section: Discussionmentioning

confidence: 99%

Interocular Symmetry and Repeatability of Foveal Outer Nuclear Layer Thickness in Congenital Achromatopsia

Mastey

Litts

Langlo

et al. 2018

Preprint

View full text Add to dashboard Cite

Cone Photoreceptors 18 19Precise: (21/35 Submitted separately as "Highlights" file) We examined the intraobserver 20 repeatability and interocular symmetry of foveal outer nuclear layer (ONL) thickness 21 measurements in patients with congenital achromatopsia. . CC-BY-NC 4.0 International license It is made available under a was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which . http://dx.doi.org/10.1101/367813 doi: bioRxiv preprint first posted online Jul. 12, 2018; Purpose: To examine the intraobserver repeatability of foveal outer nuclear layer (ONL) 25 thickness measurements and evaluate interocular symmetry for patients with achromatopsia 26 (ACHM) and controls. 27Design: Cross-sectional study. 28 Subjects: Sixty-four patients with CNGA3-or CNGB3-associated ACHM and 38 patients 29 with normal vision were recruited for analysis. 30Methods: Horizontal line scans through the fovea of each eye were acquired using 31 optical coherence tomography. Three foveal ONL thickness measurements were made by a 32 single observer using custom software to analyze repeatability. Interocular symmetry was 33 assessed using the average of the three measurements for each eye.

show abstract

“…Another notable observation in this study was that the OPL increased in volume in the occult type. OPL thickening with age and in AMD has been reported recently [27,28]. This increase in OPL volume may represent a compensatory expansion as a consequence of ONL thinning.…”

Section: Discussionmentioning

confidence: 66%

Association of Longitudinal Changes in Drusen Characteristics and Retinal Layer Volumes with Subsequent Subtype of Choroidal Neovascularisation

2019

View full text Add to dashboard Cite

Aim: To investigate the longitudinal correlation between drusen characteristics and retinal layer volumes pre conversion and subsequent type of choroidal neovascularisation (CNV). Methods: This was a single-centre retrospective study. The study participants were patients with wet age-related macular degeneration (AMD) in one eye who developed wet AMD in the contralateral eye, with at least 2 years of follow-up prior to conversion. The Moorfields Eye Hospital database was searched for eligible patients and their data were recorded. Eyes were classified as occult or classic based on fundus fluorescein angiography. Optical coherence tomography (OCT) images were analysed for drusen characteristics and retinal layer volumes were analysed over time using automated software (Topcon 3D OCT-2000 and Orion, Voxeleron LLC, respectively). All values were obtained at baseline as well as year 1 and year 2 before conversion to wet AMD. Results: Fifty-one eyes with bilateral CNV showed high correlation of type of CNV between eyes (kappa statistic 0.89). A total of 49 wet AMD eyes (29 occult, 20 classic) were analysed for drusen parameters. Two patients with retinal angiomatous proliferation were excluded. Drusen count, area, and volume did not differ by CNV type, but the rates of change of drusen area (p = 0.046) and drusen volume (0.022) were higher in the occult group in the year preceding CNV development. Of the 49 eyes, 17 (10 occult, 7 classic) with available good quality OCT were analysed for retinal layer volumes. There was a progressive reduction in outer nuclear layer (ONL) volume (p = 0.002) and an expansion in outer plexiform layer volume (p = 0.015) in eyes that developed occult CNV. Conclusion: Our study shows that rate of increase in drusen load and reduction in ONL are significant features seen in eyes developing occult CNV, highlighting new imaging markers that need to be replicated in larger studies. These markers provide insight into the pathogenesis of CNV and may serve as prognostic indicators, as classic CNV carries a poorer prognosis compared to occult CNV.

show abstract

Impacts of age and sex on retinal layer thicknesses measured by spectral domain optical coherence tomography with Spectralis

Cited by 74 publications

References 18 publications

Optical coherence tomography shows neuroretinal thinning in myelopathy of adrenoleukodystrophy

Optical coherence tomography shows neuroretinal thinning in myelopathy of adrenoleukodystrophy

Interocular Symmetry and Repeatability of Foveal Outer Nuclear Layer Thickness in Congenital Achromatopsia

Association of Longitudinal Changes in Drusen Characteristics and Retinal Layer Volumes with Subsequent Subtype of Choroidal Neovascularisation

Contact Info

Product

Resources

About