Impact of worst pattern of invasion on prognosis of oral squamous cell carcinoma: a systematic review and meta-analysis

Binmadi, Nada O.; Mohamed, Yassmin A.

doi:10.1177/03000605231206260

Cited by 2 publications

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the number of buds is recommended for the grading and classifying colorectal cancer patients, the Worst Pattern of Invasion (WPOI) has drawn more attention to risk classification in oral cancer. High-risk WPOI is marked by small tumor islands <15 cells and satellite tumor(s) located at least 1 mm from the main tumor or the nearest satellite ( 17 , 29 , 30 ). This histologic feature corresponds with the term “Single-Cell Invasion (SCI)” applied in the present study.…”

Section: Discussionmentioning

confidence: 99%

The impact of tumor budding and single-cell invasion on survival in patients with stage III/IV locally advanced oral squamous cell carcinoma- results from a prospective cohort study

Hakim,

Alsharif,

Falougy

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

IntroductionTumor budding (TB) refers to the presence of small clusters of tumor cells at the invasive front of a malignant tumor. Single tumor cell invasion (SCI) is an extreme variant of TB, in which individual loose tumor cells are present at the invasive front. Both TB and SCI are important histomorphologic risk factors postulated to indicate loss of cellular cohesion. In this study, we investigated the influence of TB and SCI on different survival outcomes in patients with locally advanced oral squamous cell carcinoma (OSCC).MethodsWe included 129 patients with locally advanced OSCC (pT3-4) from a single-center, prospectively maintained cohort. We examined the association of TB and SCI with the presence of occult lymph node metastasis using a logistic regression model. Survival probabilities were estimated using the Kaplan-Meier method and cumulative incidence functions. The association of TB and SCI on overall survival (OS), oral cancer-specific survival (OCSS), and local recurrence-free survival (LRFS) was investigated using Cox’s proportional hazards regression models. ResultsTB was detected in 98 (76%) of the tumors, while SCI was observed in 66 (51%) patients. There was a significant association between TB and the occurrence of occult lymph node metastasis (OR=3.33, CI: 1.21-10.0). On multivariate analysis, TB had no detectable impact on survival outcomes. However, SCI showed a higher risk for local recurrence (Hazards ratio (HR): 3.33, CI: 1.19 – 9.27). DiscussionThis study demonstrates that TB and SCI in locally advanced OSCC function as an independent risk factor for occult lymph node metastases, as well as local recurrences. Both histomorphologic risk factors could serve as an additional parameter for stratifying therapy and escalating multimodal treatment approaches.

show abstract

Section: Discussionmentioning

confidence: 99%