Impact of Water Exposure and Temperature Changes on Skin Barrier Function

Herrero-Fernandez, Manuel; Montero‐Vílchez, Trinidad; Díaz-Calvillo, Pablo; Romera-Vilchez, Maria; Buendía‐Eisman, A.; Arias‐Santiago, Salvador

doi:10.3390/jcm11020298

Cited by 12 publications

(9 citation statements)

References 46 publications

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“…36 A TEWL test is typically conducted to assess the integrity of the epidermal barrier, which is linked to a deficiency in the skin barrier. 37 The present study demonstrated that SHFE lotion significantly reduced transdermal water loss after 3 weeks compared with the placebo (Figure 6A). We observed a reduction in skin irritation caused by SLS exposure using a video microscope (Figure 6B).…”

Section: Discussionsupporting

confidence: 54%

The effects of fucoidan‐rich polysaccharides extracted from Sargassum horneri on enhancing collagen‐related skin barrier function as a potential cosmetic product

Kang,

Hyun,

Kim

et al. 2023

J of Cosmetic Dermatology

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BackgroundSargassum horneri came ashore after flowing from the South China Sea to Jeju Island a few years ago. This caused a significant environmental impact on coastal areas where S. horneri has accumulated because of decomposition and the release of toxic substances, such as hydrogen sulfide.AimsIn this study, we evaluated a biological ingredient prepared from fucoidan‐rich S. horneri and demonstrated its antiwrinkle effects on ultraviolet B (UVB)‐induced fibroblast cells.Materials and MethodsFucoidan samples from S. horneri were prepared according to a previously published process with modifications. The compositional analysis of S. horneri fucoidan extract (SHFE) as well as its effects on antiaging were examined to determine its utility as a functional material.ResultsSHFE exhibited antioxidant properties using 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging assay. Treatment of UVB‐induced fibroblasts with SHFE significantly increased the synthesis of procollagen compared with adenosine treatment and inhibited MMP‐1 and MMP‐3 expression. In a clinical study, SHFE lotion improved skin barrier effects in forearms and transepidermal water loss (TEWL) values were reduced after 3 weeks of use compared with a placebo.ConclusionSHFE has utility as an additive with functional antiaging effects for a range of cosmetic products as it restores skin hydration in the epidermal barrier.

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Section: Discussionsupporting

confidence: 54%

The effects of fucoidan‐rich polysaccharides extracted from Sargassum horneri on enhancing collagen‐related skin barrier function as a potential cosmetic product

Kang,

Hyun,

Kim

et al. 2023

J of Cosmetic Dermatology

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“…The total amount of vapor lost through skin and appendages under non-sweating conditions from a fixed area of SC per unit of time (g/h/m 2 ) corresponds to TEWL. [35][36][37] The effect of environmental factors on TEWL values has been studied 38,39 ; however, discrepant results have been reported regarding the effect of temperature and relative humidity. 40 The results of our present work…”

Section: Discussionmentioning

confidence: 99%

Directional assessment of the skin barrier function in vivo

Alsamad,

Stamatas

2023

Skin Research and Technology

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Introduction:The fundamental function of the epidermis is to provide an inside-out barrier to water loss and an outside-in barrier to penetration of external irritants.Transepidermal water loss (TEWL) has been extensively used as a method of estimating the skin barrier quality, typically without any consideration of directionality. The validity of TEWL as an estimate of skin permeability to external substances has been controversial in vitro and in vivo. The aim of this work was to assess the relationship between TEWL and the penetration of a topically applied external marker (caffeine) in healthy skin in vivo before and following a challenge to the barrier. Methods:The skin barrier was challenged by application of aqueous solutions of mild cleanser products under occlusion for 3 h on the forearms of nine human participants. Skin barrier quality was evaluated before and after the challenge by measuring the TEWL rate and the permeated amount of topically applied caffeine using in vivo confocal Raman microspectroscopy.Results: No skin irritation was observed following the skin barrier challenge. TEWL rates and the caffeine penetrated amount in the stratum corneum after the challenge were not correlated. A weak correlation was observed when the changes were corrected to water-only treatment. TEWL values can be influenced by environmental conditions as well as the skin temperature and water content.Conclusions: Measuring TEWL rates is not always representative of the outside-in barrier. TEWL may be useful in differentiating large changes in skin barrier function (e.g., between healthy and compromised skin) but is less sensitive to small variations following topical application of mild cleansers.

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“…From a different scope, cold outdoor temperatures and exposure to shampoo were associated with eczema aggravation. Currently, it remains unclear whether parabens, which are included in many daily consumer products such as cosmetics, shampoos and personal care products as preservative antimicrobial agents, induce or aggravate it [ 47 , 48 ]. However, a population study suggested an increased association between children aged 0–3 years exposed to parabens [ 49 ].…”

Section: Exposome In the Development Of Ad During Childhood And Teena...mentioning

confidence: 99%

The Imprint of Exposome on the Development of Atopic Dermatitis across the Lifespan: A Narrative Review

Grafanaki

Bania

Kaliatsi

et al. 2023

JCM

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Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects more than 200 million people worldwide, including up to 20% of children and 10% of the adult population. Although AD appears frequently in childhood and often continues into adulthood, about 1 in 4 adults develop the adult-onset disease. The prenatal period, early childhood, and adolescence are considered critical timepoints for the development of AD when the exposome results in long-lasting effects on the immune system. The exposome can be defined as the measure of all the exposures of an individual during their lifetime and how these exposures relate to well-being. While genetic factors could partially explain AD onset, multiple external environmental exposures (external exposome) in early life are implicated and are equally important for understanding AD manifestation. In this review, we describe the conceptual framework of the exposome and its relevance to AD from conception and across the lifespan. Through a spatiotemporal lens that focuses on the multi-level phenotyping of the environment, we highlight a framework that embraces the dynamic complex nature of exposome and recognizes the influence of additive and interactive environmental exposures. Moreover, we highlight the need to understand the developmental origins of AD from an age-related perspective when studying the effects of the exposome on AD, shifting the research paradigm away from the per se categorized exposome factors and beyond clinical contexts to explore the trajectory of age-related exposome risks and hence future preventive interventions.

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Impact of Water Exposure and Temperature Changes on Skin Barrier Function

Cited by 12 publications

References 46 publications

The effects of fucoidan‐rich polysaccharides extracted from Sargassum horneri on enhancing collagen‐related skin barrier function as a potential cosmetic product

The effects of fucoidan‐rich polysaccharides extracted from Sargassum horneri on enhancing collagen‐related skin barrier function as a potential cosmetic product

Directional assessment of the skin barrier function in vivo

The Imprint of Exposome on the Development of Atopic Dermatitis across the Lifespan: A Narrative Review

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