2020
DOI: 10.3389/fphar.2020.00481
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Abstract: The aim of this systematic review and meta-analysis of longitudinal studies was to ascertain to effects of TNF-a inhibitor therapy on body weight and BMI. Methods: Three databases (PubMed, OVID, and EMBASE) were systematically searched from inception to August 2018. We identified prospective, retrospective, and randomized controlled studies in adults with immune-mediated inflammatory diseases treated with TNF-a inhibitors based on pre-specified inclusion criteria. A random-effects model was used to estimate st… Show more

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Cited by 52 publications
(37 citation statements)
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“…A total of 1537 participants received treatment with an IL-6 pathway inhibitor, with sample sizes ranging from 13 to 805 participants. None of the studies reported correlational data and were thus imputed from a previous meta-analysis by our group [ 34 ].…”
Section: Resultsmentioning
confidence: 99%
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“…A total of 1537 participants received treatment with an IL-6 pathway inhibitor, with sample sizes ranging from 13 to 805 participants. None of the studies reported correlational data and were thus imputed from a previous meta-analysis by our group [ 34 ].…”
Section: Resultsmentioning
confidence: 99%
“…For such cases, clinical monitoring of patients’ weight with additional weight-regulating measures, such as diet counselling and physical exercise, may be necessary. It is important to mention here that weight gain may not be specific to IL-6 signaling inhibition as other cytokine inhibitors have also been shown to increase weight and BMI [ 34 ].…”
Section: Discussionmentioning
confidence: 99%
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