Impact of the Triglycerides to High-Density Lipoprotein Cholesterol Ratio on the Incidence and Progression of CKD: A Longitudinal Study in a Large Japanese Population

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

“…Previous investigations have shown that higher TG/HDL-c is independently correlated with coronary heart disease [10, 39] and all-cause mortality [40]. Several cross-sectional [41] and longitudinal studies [42, 43] have also shown a relationship between TG/HDL-c and CKD. In the present analysis, we were able to reproduce this finding utilizing the new CKD-EPI equation.…”

LDL-C/apoB and HDL-C/apoA-1 ratios predict incident chronic kidney disease in a large apparently healthy cohort

“…Oxidized LDL induced renal injury in in vitro studies [4e6]. One study suggested this relationship with small dense LDL-C as a mechanism for the effect of a higher TG/HDL-C ratio on the incidence of CKD in a Japanese population [7]. In our study, baseline TG and HDL-C levels were independently associated with the development of CKD and, in particular, a higher TG/HDL-C ratio was associated with a higher risk of incident CKD.…”

“…The Physicians' Health Study showed that elevated TC, high non-HDL-C, a high TC/ HDL ratio, and low HDL are significantly associated with an increased risk of developing renal dysfunction [10]. A higher TG/ HDL-C ratio in the Japanese population affects the decline in eGFR and incidence of CKD [7]. However, the results of these studies could not answer which lipid or lipoprotein better predicts the development of renal dysfunction because the results were inconsistent [4].…”

Circulating CD34-positive cells, glomerular filtration rate and triglycerides in relation to hypertension

“…In the present study, triglycerides were significantly inversely correlated with HDLcholesterol, with a simple correlation coefficient of r ¼ À0.42 (P < 0.001) calculated for total subjects, r ¼ À0.39 (P ¼ <0.001) for non-hypertensive subjects, and r ¼ À0.44 (P < 0.001) for hypertensive subjects. A higher TG-HDL cholesterol ratio (TG-HDL) was previously found to indicate insulin resistance among the general population [20], while another study reported increased TG-HDL to be independently associated with atherosclerosis [21], lower GFR, and CKD incidence [22] among the general population. Insulin resistance might therefore have an influence on the correlation between triglycerides and endothelial dysfunction.…”