Impact of the SARS‐CoV‐2 virus on male reproductive health

Nassau, Daniel E.; Best, Jordan C.; Kresch, Eliyahu; González, Daniel; Khodamoradi, Kajal; Ramasamy, Ranjith

doi:10.1111/bju.15573

Cited by 56 publications

(67 citation statements)

References 64 publications

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“…Direct SARS-CoV-2 infection of Leydig cells may lead to testicular hypofunction, especially in severe diseases. 31 In a postmortem examination of the testes from 12 COVID-19 patients conducted by Yang M, et al, the mean number of Leydig cells per tubule cross-section in COVID-19 testes was significantly lower compared with 5 non-COVID-19 patients' testes (2,2 vs. 7,8; p<0,001). In addition, only 3 out of 12 COVID-19 patients' testes showed normal signs of spermatogenesis.…”

Section: Discussionmentioning

confidence: 94%

long-term impact of COVID-19 infection on semen quality of the COVID-19 survivors

Sunnu

Tribowo

Juwita

et al. 2022

ijhs

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Background. Several studies have shown the short-term effects of COVID-19 on semen quality, but not as many for the long-term effects. This follow-up study aims to explore the long-term effects of COVID-19 on male fertility by comparing semen parameters of patients recovering from COVID-19 infection. Methods. Fourteen subjects aged >18 years old who had a history of resolved COVID-19 infection with previous evidence of laboratory-confirmed positive SARS-CoV-2 nasopharyngeal PCR swab result, and had a previous history of infertility after COVID-19 infection based on the evidence of the semen analysis within 6 months or longer were recruited in this study. Analysis of the semen parameter of all fourteen subjects was performed, including semen volume, pH, sperm concentration, total, progressive, non-progressive, and immotile motility percentage, morphology percentage, leukocyte, erythrocyte, and immature sperm cells parameters. The semen analysis obtained from this current semen analysis was compared with individual baseline semen analysis results, which were obtained in the resolution phase of COVID-19 infection, 6 months or longer from the current semen analysis. Results. Mean pH decreased significantly in follow-up semen analysis, with baseline vs. follow-up 7.9 vs 7.4 (p=0.002; 95%CI=0.3-0.67).

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Section: Discussionmentioning

confidence: 94%

long-term impact of COVID-19 infection on semen quality of the COVID-19 survivors

Sunnu

Tribowo

Juwita

et al. 2022

ijhs

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“…Six main targets were classified: receptor tyrosine kinase (RTK), 20S proteasome β5, ion channel, DNA synthesis, antibacteria or protozoa drugs and natural products ( Figure 1 b). Numerous studies report RTK inhibitors, ion channel inhibitors, DNA synthesis inhibitors, antibacteria or protozoa drugs and natural products to be arbovirus antivirals [ 14 , 15 , 16 , 17 ]. However, little work has been conducted regarding 20S proteasome β5 inhibitors as direct-acting antivirals.…”

Section: Resultsmentioning

confidence: 99%

High-Throughput Screening of FDA-Approved Drug Library Reveals Ixazomib Is a Broad-Spectrum Antiviral Agent against Arboviruses

Ding¹,

Tang²,

Binghui³

et al. 2022

Viruses

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The emergence of significant arboviruses and their spillover transmission to humans represent a major threat to global public health. No approved drugs are available for the treatment of significant arboviruses in circulation today. The repurposing of clinically approved drugs is one of the most rapid and promising strategies in the identification of effective treatments for diseases caused by arboviruses. Here, we screened small-molecule compounds with anti-tick-borne encephalitis virus, West Nile virus, yellow fever virus and chikungunya virus activity from 2580 FDA-approved drugs. In total, 60 compounds showed antiviral efficacy against all four of the arboviruses in Huh7 cells. Among these compounds, ixazomib and ixazomib citrate (inhibitors of 20S proteasome β5) exerted antiviral effects at a low-micromolar concentration. The time-of-drug-addition assay suggested that ixazomib and ixazomib citrate disturbed multiple processes in viruses’ life cycles. Furthermore, ixazomib and ixazomib citrate potently inhibited chikungunya virus replication and relieved virus-induced footpad swelling in a mouse model. These results offer critical information which supports the role of ixazomib as a broad-spectrum agent against arboviruses.

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“…Every day, a new study reveals the widespread effects of COVID‐19 on different organs throughout the body. Erectile dysfunction has also been shown to be one of these effects (Kaynar et al, 2022 ; Nassau et al, 2021 ). It has been suggested that the underlying pathophysiological mechanism of ED is endothelial damage.…”

Section: Discussionmentioning

confidence: 99%

A factor not to be ignored in post‐COVID ‐19 erectile dysfunction; psychological effect, a prospective study

Sevim¹,

Alkış²,

Kartal³

et al. 2022

Andrologia

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It was aimed to show the effect of anxiety and depression on erectile dysfunction seen after coronavirus disease‐2019 (COVID‐19). Between March and July 2021, the participants completed the International Index of Erectile Function, Beck Depression Inventory and Generalised Anxiety Disorder 7 forms at the beginning and after the 1st month of the disease. We investigated the psychological impact of COVID‐19 on the development of erectile dysfunction. The mean age of 156 male patients in the study was 54.74 ± 8.01 years. It was determined that the mean International Index of Erectile Function scores of the patients before COVID‐19 were 73.42 ± 3.43 and decreased to 68.28 ± 12.86 after COVID‐19 ( p < .01). The patients’ erectile function scores were significantly lower after COVID‐19 (29.45 ± 1.23, 27.69 ± 4.33, p < .01, respectively). Their Beck Depression Inventory scores were statistically significantly higher after COVID‐19 (1.69 ± 2.56, 2.22 ± 2.79, p < .01, respectively). Their Generalised Anxiety Disorder 7 scores were also statistically significantly higher after COVID‐19 (4.69 ± 1.63 6.56 ± 2.40, p < .01, respectively). A negative correlation was found between the increase in the Beck Depression Inventory score during the pandemic process and the decrease in the International Index of Erectile Function score ( r = −0.356, p = <.001). A negative correlation was also found between the increase in the Generalised Anxiety Disorder 7 score and the decrease in the International Index of Erectile Function score ( r = −0.200, p = .012). One of the main factors post‐COVID‐19 erectile dysfunction is anxiety and depression due to the disease.

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Impact of the SARS‐CoV‐2 virus on male reproductive health

Cited by 56 publications

References 64 publications

long-term impact of COVID-19 infection on semen quality of the COVID-19 survivors

long-term impact of COVID-19 infection on semen quality of the COVID-19 survivors

High-Throughput Screening of FDA-Approved Drug Library Reveals Ixazomib Is a Broad-Spectrum Antiviral Agent against Arboviruses

A factor not to be ignored in post‐COVID ‐19 erectile dysfunction; psychological effect, a prospective study

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