Impact of the Magnitude of the Initial ST-Segment Elevation on Left Ventricular Function in Patients With Anterior Acute Myocardial Infarction

Kurisu, Satoshi; Inoue, Ichiro; Kawagoe, Takuji; Ishihara, Masaharu; Sakai, Yuji; Matsumoto, Naoya; Hata, Tomoko; Nakama, Yasuharu; Kisaka, Tomohiko; Kijima, Yasufumi

doi:10.1253/circj.68.903

Cited by 10 publications

(4 citation statements)

References 26 publications

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“…However, because the amount of ST segment elevation in other studies 18 was associated with a greater myocardial infarct size and a greater reduction in the LV EF, it is reasonable that ST elevation in patients with TS indicates a larger area of myocardial injury and, consequently, a worse outcome. 19,20…”

Section: Discussionmentioning

confidence: 99%

Impact of triggering event in outcomes of stress-induced (Takotsubo) cardiomyopathy

Yerasi

Koifman

Weissman

et al. 2016

European Heart Journal: Acute Cardiovascular Care

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Our study showed that different triggers for Takotsubo syndrome confer different prognoses, with medical illness conferring the worst prognosis. Overall, the in-hospital death rate was low and mostly related to non-cardiac death secondary to the underlying medical illness. Although an unidentified trigger was prevalent in a third of this population, efforts should be made to identify the triggering event to classify the risk group of patients with Takotsubo syndrome.

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Section: Discussionmentioning

confidence: 99%

Impact of triggering event in outcomes of stress-induced (Takotsubo) cardiomyopathy

Yerasi

Koifman

Weissman

et al. 2016

European Heart Journal: Acute Cardiovascular Care

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“…In this regard, Kurisu et al reported that more than 10 mm ∑ST elevation and severely reduced LV ejection fraction were frequently observed in wide anterior MI with less collateral branches. 23 …”

Section: St Elevation In Extensive Precordial Leadmentioning

confidence: 99%

Clinical Features of Emergency Electrocardiography in Patients With Acute Myocardial Infarction Caused by Left Main Trunk Obstruction

Hirano

Tsuchiya

Nishigaki

et al. 2006

Circ J

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tandard 12-lead electrocardiography (ECG) is the simplest examination for diagnosing acute myocardial infarctions (AMI) because generally the infarct area and the segments with ST elevation correspond well with each other; that is, for AMI of the left anterior descending artery (LAD), right coronary artery (RCA) and left circumflex artery (LCX), the specificity of ST segment elevation is more than 90%. [1][2][3][4][5] Recording the ECG in AMI is very useful for making a prompt and precise diagnosis of the culprit artery, but for left main trunk (LMT) infarction, it is sometimes difficult to obtain the characteristic ECG findings because lethal arrhythmias, such as ventricular fibrillation, or atrioventricular block with hemodynamic compromise often occurs. These unstable hemodynamics can lead to cardiac arrest before the patient arrives at the hospital and thus a poor prognosis. Consequently, it is important to diagnose LMT infarction from the ECG on admission and institute coroCirculation Journal Vol.70, May 2006 nary interventions, such as mechanical assistance by an intra-aortic balloon pump, or surgical treatment without any delay.Some research has indicated that ST-segment elevation in lead aVR may indicate LMT infarction, 5-7 but to the best of our knowledge, the ECG features in LMT infarction have not been fully described. Methods Study PopulationThe records of 2,190 patients admitted to Gifu University Hospital and its referral hospitals with AMI from 1988 to 2004 were retrospectively collected from the data bank and 140 were enrolled and divided into 4 equal groups according to the location of the culprit artery: LMT, LAD, RCA (#3 and #4 AV) and LCX (#13 and #14). All patients immediately underwent coronary angiography and the extent of stenosis was evaluated according to American Heart Association classification. Exclusion criteria were (1) prior Q-wave myocardial infarction (MI), (2) prior coronary artery bypass graft operation, and (3) inability to identify the culprit lesion as a result of severe stenosis in 2 or 3 vessels. 2,3 A lesion was considered to be the culprit when it occluded or showed severe narrowing and ulceration with or without thrombus.Standard 12-lead surface ECG (paper speed: 25 mm/s, calibration: 1 mV =10 mm) was recorded as soon as possible after admission and various parameters (heart rate (HR),

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“…[1][2][3][4][5][6][7] Recent advancements in transthoracic Doppler echocardiography (TTDE) have enabled direct visualization and evaluation of coronary blood flow velocity, especially in the distal left anterior descending coronary artery (LAD). [8][9][10][11][12][13][14][15][16][17][18] This technique has been applied for noninvasive evaluation of Thrombolysis in Myocardial Infarction (TIMI) flow grade, which is widely used as a valuable index of coronary reperfusion.…”

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confidence: 99%

Correlation Between Distal Left Anterior Descending Artery Flow Velocity by Transthoracic Doppler Echocardiography and Corrected TIMI Frame Count Before Mechanical Reperfusion in Patients With Anterior Acute Myocardial Infarction

Lee

Minagoe

Hamasaki

et al. 2005

Circ J

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uick and accurate evaluation of coronary reperfusion in patients with acute myocardial infarction (AMI) is essential to determine whether thrombolysis and/or percutaneous coronary intervention (PCI) is required to achieve reperfusion. [1][2][3][4][5][6][7] Recent advancements in transthoracic Doppler echocardiography (TTDE) have enabled direct visualization and evaluation of coronary blood flow velocity, especially in the distal left anterior descending coronary artery (LAD). [8][9][10][11][12][13][14][15][16][17][18] This technique has been applied for noninvasive evaluation of Thrombolysis in Myocardial Infarction (TIMI) flow grade, which is widely used as a valuable index of coronary reperfusion. 19 Our previous study demonstrated that preserved coronary artery flow velocity as determined by TTDE enables differentiation of TIMI 3 from TIMI 0-2 in patients with anterior AMI before PCI. 20 However, the conventional TIMI classification is a semi-quantitative grading of coronary reperfusion after AMI and is thereby limited by its subjective and categorical nature. TIMI frame count by angiography is a simple, objective, reproducible and quantitative measure of coronary reperfusion 21 that allows for better prediction of clinical outcomes after AMI. 22 An intracoronary Doppler guidewire study has demonstrated that distal coronary flow velocity inversely correlates with the TIMI frame count before PCI. 23 Therefore, we hypothesized that the measurement of LAD flow velocity by TTDE would enable quantitative evaluation of the TIMI frame count by angiography in patients with anterior AMI. To test this hypothesis, we prospectively compared reperfused distal LAD flow velocity by TTDE with the TIMI frame count by angiography in patients with anterior AMI before mechanical reperfusion therapy. Methods Study GroupBetween August 2001 and November 2003, 56 consecutive patients at the Department of Cardiology, Kagoshima City Hospital with a first anterior AMI before mechanical reperfusion were enrolled in the study. Inclusion criteria were: (1) typical chest pain lasting >30 min and <12 h from onset; (2) ST-segment elevation >0.2 mV in precordial leads; (3) subsequent increase in serum creatine kinase ≥2- Methods and ResultsColor and pulsed TTDE was performed to evaluate distal left anterior descending coronary artery (LAD) reperfusion in 56 consecutive patients with a first anterior AMI before coronary intervention, and these findings were compared with the corrected TIMI frame count (cTFC) by subsequent angiography. Twenty-four of the 56 patients had LAD reperfusion (TIMI 2 or 3) by angiography. Visual antegrade distal LAD flow by color TTDE was detected in 21 of these 24 patients. In the 21 patients, diastolic peak velocity of the distal LAD flow by pulsed TTDE showed a significant correlation with cTFC by angiography (r=-0.74, p<0.001). The diagnosis of high risk with angiographic cTFC >40 by distal LAD peak velocity <21 cm/s using TTDE had a sensitivity, specificity, and accuracy of 82%, 93%, and 91%, respectively. Concl...

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Impact of the Magnitude of the Initial ST-Segment Elevation on Left Ventricular Function in Patients With Anterior Acute Myocardial Infarction

Cited by 10 publications

References 26 publications

Impact of triggering event in outcomes of stress-induced (Takotsubo) cardiomyopathy

Impact of triggering event in outcomes of stress-induced (Takotsubo) cardiomyopathy

Clinical Features of Emergency Electrocardiography in Patients With Acute Myocardial Infarction Caused by Left Main Trunk Obstruction

Correlation Between Distal Left Anterior Descending Artery Flow Velocity by Transthoracic Doppler Echocardiography and Corrected TIMI Frame Count Before Mechanical Reperfusion in Patients With Anterior Acute Myocardial Infarction

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