Impact of the carotenoid astaxanthin on phagocytic capacity and ROS/RNS production of human neutrophils treated with free fatty acids and high glucose

Abstract

In summary, this study showed that both high glucose and a mixture of FFA are potent inducers of ROS/RNS production on neutrophils as observed by higher levels of superoxide anion, hydrogen peroxide and NO production. Also, these metabolites decrease the phagocytic capacity of neutrophils and increase the G6PDH activity. Overall, ASTA-treatment was able to reduce partially ROS/RNS production by reducing the availability of NADPH and recover phagocytic capacity of neutrophils.

Fatty acids as modulators of neutrophil recruitment, function and survival

“…On the other hand, another group evaluated the effect of palmitic acid on human neutrophil reactive oxygen species production using luminol-enhanced chemiluminescent (Wanten et al, 2002) and found that this fatty acid, at 1 mM, induces the production of significant amounts of radical oxygen species in the absence of any neutrophil stimulus. Additionally, a study performed in isolated human neutrophils reported a stimulatory effect of a mixture of fatty acids (the most abundant components of this mixture were palmitic (31%) and stearic acids (41%)) on the production of reactive oxygen species (Guerra and Otton, 2011). These findings suggest a role of palmitic acid (depending on its concentration) on reactive oxygen species production by neutrophils, which may be relevant for the inflammatory process and tissue damage and for the host organism's protection against pathogenic microorganisms.…”

Green tea polyphenols change the profile of inflammatory cytokine release from lymphocytes of obese and lean rats and protect against oxidative damage

“…The maximum activity of this enzyme was previously described by Guerra and Otton [35] and was based on the conversion of NADP + in NADPH in the presence of glucose-6-phosphate.…”

Astaxanthin as feed supplement in aquatic animals

“…), sun proofing (O'Connor & O'Brien ; Suganuma et al . ), antidiabetic activities (Maoka & Etoh ; Guerra & Otton ) and among other various health benefits due to the potent antioxidant activity of this fat‐soluble pigment. Astaxanthin exists in various stereoisomers characterized by different configuration of the two hydroxyl groups on the molecule (Fig.…”