Impact of tart cherries polyphenols on the human gut microbiota and phenolic metabolites in vitro and in vivo

Mayta-Apaza, Alba C.; Pottgen, Ellen; Bodt, Jana De; Papp, Nóra; Marasini, Daya; Howard, Luke R.; Abrankó, László; Wiele, Tom Van de; Lee, Sun‐Ok; Carbonero, Franck

doi:10.1016/j.jnutbio.2018.04.001

Cited by 96 publications

(80 citation statements)

References 92 publications

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“…In a small‐scale randomized controlled feeding study, a cranberry diet containing 30 g per day freeze‐dried whole cranberry powder increased Bacteroidetes and decreased Firmicutes population in healthy adults after 5 days of treatments compared to placebo powder diet . Likewise, tart cherry consumption also changed gut‐microbiota composition in healthy participants . Initially, participants had low levels of Bacteroides genera.…”

Section: Impact Of Gut Microbiota On Obesity and Inflammationmentioning

confidence: 98%

“…According to bioavailability and absorption data, most of the ingested anthocyanins are actively metabolized and converted into small metabolites by indigenous bacteria such as Bifidobacterium spp . and Lactobacillus spp ., which possess probiotic effects and can be stimulated by polyphenols . These bacteria possess the beta‐glycosidase enzyme required to catalyze metabolic reactions which could encourage colonization of these bacteria in the gut .…”

Section: Impact Of Gut Microbiota On Obesity and Inflammationmentioning

confidence: 99%

“…In another study, 5 mL of tart cherry treatment for 48 h in vitro using conditions which mimicked gastric, intestine, and colon environments (15 mL) increased Bacteroides and Bifidobacterium which could be associated with increased chlorogenic acid in tart cherry juice concentrate. Increased Bacteroides may be due to high levels of polysaccharides (carbohydrates and sugars) in tart cherry juice concentrate, the key energy source of Bacteroides …”

Section: Impact Of Gut Microbiota On Obesity and Inflammationmentioning

confidence: 99%

“…Initially, participants had low levels of Bacteroides genera. However, after a short, 5‐day consumption period of 8 oz tart cherry concentrate juices, Bacteroides or Prevotella and Bifidobacterium increased in the stool . Moreover, consumption of 272 mL per day red wine polyphenols for 30 days increased the numbers of fecal Bifidobacteria and Lactobacillus (typically involved in intestinal barrier protection), as well as Faecalibacterium prausnitzii and Roseburia , known for butyrate production .…”

Section: Impact Of Gut Microbiota On Obesity and Inflammationmentioning

confidence: 99%

“…This hypothetical concept has been applied to explore potential effects of anthocyanins on gut bacteria composition during obesity . Studies have reported beneficial impacts of anthocyanins on gut‐microbiota composition and inflammatory status using both in vivo and in vitro studies …”

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Anthocyanins in Obesity‐Associated Inflammation and Changes in Gut Microbiome

Jayarathne

Stull

Park

et al. 2019

Molecular Nutrition Food Res

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Obesity is a complex disease and a major public health epidemic. Chronic, low‐grade inflammation is a common underlying feature of obesity and associated metabolic diseases; adipose tissue is a major contributor to this systemic inflammation. Evidence shows that obesity‐associated inflammation may originate from gut dysfunction, including changes in intestinal bacteria or microbiome profiles. Increasingly, food and plant bioactive compounds with antioxidant and anti‐inflammatory properties are proposed to ameliorate obesity‐associated inflammation. Among these, the health‐promoting effects of anthocyanin‐rich foods are of interest here. Specifically, this review summarizes the reported benefits of anthocyanins in obesity‐associated inflammation and underlying molecular mechanisms, including the role of gut microbiome and cell signaling pathways regulated by anthocyanins both in vivo and in vitro.

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Section: Impact Of Gut Microbiota On Obesity and Inflammationmentioning

confidence: 98%

Section: Impact Of Gut Microbiota On Obesity and Inflammationmentioning

confidence: 99%

Section: Impact Of Gut Microbiota On Obesity and Inflammationmentioning

confidence: 99%

Section: Impact Of Gut Microbiota On Obesity and Inflammationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Protective Effects of Anthocyanins in Obesity‐Associated Inflammation and Changes in Gut Microbiome

Jayarathne

Stull

Park

et al. 2019

Molecular Nutrition Food Res

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Dietary Anthocyanins

Fernandes¹,

Oliveira²,

Marques³

et al. 2020

Dietary Polyphenols

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Impact of increasing concentration of tart and sweet cherries juices concentrates on healthy mice gut microbiota

2020

Self Cite

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Cherries are an excellent source of dietary polyphenols and are marketed as sports and health dietary supplements. However, there are still limited direct evidence for their purported nutritional and health benefits. Gut microbiota modulation ought to be tested because most polyphenols reach the colon where they undergo microbial metabolization to bioactive and bioavailable metabolites. In the present study, varying dilutions of three concentrate cherries juices, Montmorency tart cherry juice, Balaton tart cherry juice, and sweet cherry juice, were examined to determine their potential effect on the murine gut microbiota composition. Forty-five mice were randomly assigned to three different groups. Each group received an increased concentration of its assigned juices (1/20, 1/15, 1/10, 1/7, and 1/4 [v/v]) every 5 days for 25 days. Fecal samples were collected after each concentration change for microbiota characterization by high-throughput 16S rRNA gene sequencing using Illumina Miseq. The results revealed consistent gut microbiota modulation based on concentration regardless of the juice type, but not in a true dose-dependent manner. The two median concentrations and the two highest were significantly different from each other and from the baseline and lowest concentration. Increasing cherries consumption consistently resulted in significant increase of the relative abundance of Barnesiella and Akkermansia, whereas Bacteroides abundance was negatively correlated with the concentration of the juice. Overall, we demonstrate that cherries induce a beneficial modulation of the murine gut microbiota, and that amounts of fruits consumed need to be considered to devise appropriate health and nutrition studies. K E Y W O R D S dietary supplement, gut microbiota, polyphenols, sweet cherries, tart cherries 1 INTRODUCTION Cherry fruits belong to the genus Prunus from the family Rosaceae. The most common types of cherries consumed by humans are Prunus cerasus, designated as sour or tart cherries, and Prunus avium, designated This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Impact of tart cherries polyphenols on the human gut microbiota and phenolic metabolites in vitro and in vivo

Cited by 96 publications

References 92 publications

Protective Effects of Anthocyanins in Obesity‐Associated Inflammation and Changes in Gut Microbiome

Protective Effects of Anthocyanins in Obesity‐Associated Inflammation and Changes in Gut Microbiome

Dietary Anthocyanins

Impact of increasing concentration of tart and sweet cherries juices concentrates on healthy mice gut microbiota

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