Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma

Abstract

Long-term outcome following resection of IHCC is poor. A pre-operative NLR >or= 5 was an adverse predictor of disease-free survival and was associated with an aggressive tumour biology profile.

Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma

“…Chronic inflammation and biliary irritation are, however, commonly shared among these diseases (40). These support recent findings that inflammation-based scores or parameters may be used as prognostic markers for patients with cholangiocarcinoma (36,37). In this study, we demonstrated that the inflammation-based prognostic score, GPS, is associated with the recurrence and overall survival of ICC patients and may be used as an independent prognostic marker.…”

“…Preoperative NLR is correlated with the overall survival of ICC patients, and NLR>5 is an independent risk factor for recurrence (36). GPS is an independent prognostic factor for extrahepatic cholangiocarcinoma according to a study on 62 patients (37).…”

A new prognostic scoring system using factors available preoperatively to predict survival after operative resection of perihilar cholangiocarcinoma

“…The Glasgow prognostic score, reported by Forrest et al for non-small-cell lung cancer, is widely known as an indicator of SIR 23 . The gastrointestinal cancers also associated with SIR: intrahepatic cholangiocarcinoma, colorectal cancer, liver metastases of colon cancer origin, and hepatocellular cancer 19,20,[24][25][26]41 . However, only a few reports were available on perihilar cholangiocarcinoma 34,42 .…”

“…Recently, several reports have indicated that the state of the Systemic Inflammatory Response (SIR) provides significant information about the prognoses of a variety of cancers [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] . Neutrophil-lymphocyte ratio (NLR), which reflects SIR, has been reported as a prognostic factor in gastrointestinal cancers, including intrahepatic cholangiocarcinoma 19 and colorectal cancer 20 .…”

“…Neutrophil-lymphocyte ratio (NLR), which reflects SIR, has been reported as a prognostic factor in gastrointestinal cancers, including intrahepatic cholangiocarcinoma 19 and colorectal cancer 20 . Platelet-lymphocyte ratio (PLR) has also been described as a prognostic factor for pancreatic cancer 21 .…”