Impact of surgery in patients with metastatic soft tissue sarcoma: A monocentric retrospective analysis

Abstract

Repeated resections of metastases from different localizations are a strong predictor for prolonged survival. We suggest that the progression-free interval after metastasectomy should be considered as a predictive factor for benefit from further surgery.

Long‐term results of surgical resection of lung metastases from soft tissue sarcoma: A single center experience

“…Two favorable prognostic factors for 5‐year DFS after complete resection of pulmonary metastasis were identified: a single nodule resected at last complete resection and a DFI over 1.3 years. Our results is in concordance with previous studies in which a single pulmonary metastatic lesion, DFI of greater than twelve months, negative resection margins at metastectomy, histologic subtype of leiomyosarcoma, minimally invasive resection) and younger age have been reported to be favorable prognostic factors after metastasectomy. The endpoint of all these previous studies has been OS, while the present study examined prognostic factors for long‐term DFS.…”

“…Large retrospective studies from specialist centers and a systematic review have shown 5‐year survival between 13% and 52% after complete resection of lung metastases. However, 5‐year OS is not necessarily equal to cure due to the variable clinical course of STS.…”

“…Solitary pulmonary metastasis and oligometastases are a common manifestation in STS. Aggressive surgical management of pulmonary metastasis, including repeat metastasectomies, has achieved an important role in STS treatment but without level I or II evidence . Approximately 25% of patients are alive 5 years after surgery of pulmonary metastases, but most studies do not reveal whether these patients live with or without relapse .…”

“…Aggressive surgical management of pulmonary metastasis, including repeat metastasectomies, has achieved an important role in STS treatment but without level I or II evidence. 1,[7][8][9][10][11][12][13][14] Approximately 25% of patients are alive 5 years after surgery of pulmonary metastases, but most studies do not reveal whether these patients live with or without relapse. 4 No randomized trials to compare survival after surgery and nonsurgical treatment have been published.…”

Rethinking the Role of Radiation Therapy in the Management of Epithelial Ovarian Cancer

“…The clinical implication of this concept is that aggressive local treatment of limited metastatic disease may contribute to progression-free survival (PFS). This concept is clinically supported by the positive impact on long term survival of resecting liver metastases from colon cancer [7] and pulmonary metastases from soft tissue sarcoma [8]. A review of 1001 consecutive cases of hepatic resection for metastatic colorectal cancer reported a 5-year survival of 37% and 10-year survival of 22%.…”