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Cited by 17 publications
(12 citation statements)
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“…For univariable MR analysis, we selected the inverse-variance weighted (IVW) as the main MR analysis method. Meanwhile, we also selected other additional MR analysis methods, including weighted median, MR-Egger method, and MR-PRESSO, as used in recent MR studies ( Bowden et al, 2015 ; Burgess and Thompson, 2017 ; Liu et al, 2018 ; Larsson et al, 2020 ; Au Yeung et al, 2021b ; Sun et al, 2021 ; Yuan et al, 2021 ; Zhao and Schooling, 2021 ; Zhuang et al, 2021b ). For multivariable MR analysis, we selected the multivariable IVW method, multivariable median-based method, and multivariable MR-Egger method.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…For univariable MR analysis, we selected the inverse-variance weighted (IVW) as the main MR analysis method. Meanwhile, we also selected other additional MR analysis methods, including weighted median, MR-Egger method, and MR-PRESSO, as used in recent MR studies ( Bowden et al, 2015 ; Burgess and Thompson, 2017 ; Liu et al, 2018 ; Larsson et al, 2020 ; Au Yeung et al, 2021b ; Sun et al, 2021 ; Yuan et al, 2021 ; Zhao and Schooling, 2021 ; Zhuang et al, 2021b ). For multivariable MR analysis, we selected the multivariable IVW method, multivariable median-based method, and multivariable MR-Egger method.…”
Section: Methodsmentioning
confidence: 99%
“…Both assumption 2 and assumption 3 are known as no pleiotropy, as described in recent MR studies (Larsson et al, 2020;Au Yeung et al, 2021b;Sun et al, 2021;Yuan et al, 2021;Zhao and Schooling, 2021;Zhuang et al, 2021b). Hence, we conducted a pleiotropy analysis using the MR-Egger intercept test (Bowden et al, 2015;Burgess and Thompson, 2017) and the MR pleiotropy residual sum and outlier (MR-PRESSO) test (Verbanck et al, 2018); both have widely used in recent MR studies (Larsson et al, 2020;Au Yeung et al, 2021b;Sun et al, 2021;Yuan et al, 2021;Zhao and Schooling, 2021;Zhuang et al, 2021b). The significance threshold P < 0.05 indicated evidence of pleiotropy.…”
Section: Pleiotropy Analysismentioning
confidence: 99%
“…Furthermore, MR investigations have shown that genetic evidence of increased serum calcium levels did not improve eBMD (55,56).…”
Section: Discussionmentioning
confidence: 99%
“…In the recent 3 years, a lot of factors that had been reported related to osteoporosis before have been re-evaluated by MR. Some were further confirmed to be associated with BMD, for instance, serum calcium ( Sun et al, 2021 ), sex hormone-binding globulin ( Qu et al, 2021 ) and age at menarche ( Magnus et al, 2020 ), while others such as vascular endothelial growth factor, uric acid and serum vitamin D got no evidence for their correlations with osteoporosis ( Lee and Song, 2019 ; Sun et al, 2019 ; Keller-Baruch et al, 2020 ). In a previous MR study of heel-ultrasound estimated BMD ( Folkersen et al, 2020 ), there were no causal effects of MMP-1, 3, 7, 10, 12 in the European population.…”
Section: Discussionmentioning
confidence: 99%