Impact of Renal Failure on Liver Transplantation Survival

Afonso, R.C.; Hidalgo, R.; Zurstrassen, M.P.V.C.; Fonseca, Luís; Pandullo, Fernando Luis; Rezende, Marcelo Bruno de; Meira-Filho, S.P.; Ferraz-Neto, Ben Hur

doi:10.1016/j.transproceed.2008.02.062

Cited by 36 publications

(35 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reasons for Re-LT are summarized in Table 4. Table 5 shows reasons for late Re-LT. 55.2% (n ¼ 85), (p ¼ 0.01). 3.1% (n ¼ 7) and 6.5% (n ¼ 10) had SIRF at T1 and T2 (p ¼ 0.118).…”

Section: Graft Survivalmentioning

confidence: 95%

See 1 more Smart Citation

Twenty-Year Longitudinal Follow-Up After Orthotopic Liver Transplantation: A Single-Center Experience of 313 Consecutive Cases

Schoening

Buescher

Rademacher

et al. 2013

American Journal of Transplantation

106

View full text Add to dashboard Cite

y These authors have contributed equally to this work.With excellent short-term survival in liver transplantation (LT), we now focus on long-term outcome and report the first European single-center 20-year survival data. Three hundred thirty-seven LT were performed in 313 patients (09/88-12/92). Impact on long-term outcome was studied and a comparison to life expectancy of matched normal population was performed. A detailed analysis of 20-years follow-up concerning overweight (HBMI), hypertension (HTN), diabetes (HGL), hyperlipidemia (HLIP) and moderately or severely impaired renal function (MIRF, SIRF) is presented. Patient and graft survival at 1, 10, 20 years were 88.4%, 72.7%, 52.5% and 83.7%, 64.7% and 46.6%, respectively. Excluding 1-year mortality, survival in the elderly LT recipients was similar to normal population. Primary indication (p < 0.001), age (p < 0.001), gender (p ¼ 0.017), impaired renal function at 6 months (p < 0.001) and retransplantation (p ¼ 0.034) had significant impact on patient survival. Recurrent disease (21.3%), infection (20.6%) and de novo malignancy (19.9%) were the most common causes of death. Prevalence of .2%, p < 0.001), p ¼ 0.01) and HBMI (33.2-45%, p ¼ 0.014) increased throughout follow-up, while prevalence of HLIP (78.0-47.6%, p < 0.001) declined. LT has conquered many barriers to achieve these outstanding long-term results. However, much work is needed to combat recurrent disease and side effects of immunosuppression (IS).

show abstract

“…Reasons for Re-LT are summarized in Table 4. Table 5 shows reasons for late Re-LT. 55.2% (n ¼ 85), (p ¼ 0.01). 3.1% (n ¼ 7) and 6.5% (n ¼ 10) had SIRF at T1 and T2 (p ¼ 0.118).…”

Section: Graft Survivalmentioning

confidence: 95%

“…As impaired renal function has turned out to be an independent risk factor for longterm survival after LT, the prognostic value of low eGFR for long-term outcome needs to be further evaluated. Several authors have reported the importance of assessing pre-and posttransplant renal functions (54,55).…”

Section: Twenty-year Survival After Liver Transplantationmentioning

confidence: 99%

Twenty-Year Longitudinal Follow-Up After Orthotopic Liver Transplantation: A Single-Center Experience of 313 Consecutive Cases

Schoening

Buescher

Rademacher

et al. 2013

American Journal of Transplantation

106

View full text Add to dashboard Cite

show abstract

“…Afonso and colleagues analyzed data collected prospectively from 152 consecutive LTs performed by the same team from March 2003 to November 2007. 20 They observed that patients who developed severe renal failure post-LT (serum creatinine .3 mg/dL or needing RRT) had worse outcomes compared with other patients; 95.29% vs 69.69% and 86.95% vs 41.66% for early and 1-year survivals, respectively (P , 0.001). 20 However, follow-up was shorter and the study included fewer patients compared with our study.…”

mentioning

confidence: 99%

“…20 They observed that patients who developed severe renal failure post-LT (serum creatinine .3 mg/dL or needing RRT) had worse outcomes compared with other patients; 95.29% vs 69.69% and 86.95% vs 41.66% for early and 1-year survivals, respectively (P , 0.001). 20 However, follow-up was shorter and the study included fewer patients compared with our study. In addition, our study is important as it does highlight the association of both pre-transplant and post-transplant renal failure with overall mortality.…”

mentioning

confidence: 99%

Kidney function and mortality post-liver transplant in the Model for End-Stage Liver Disease era

Sethi

Estrella²,

Ugarte³

et al. 2011

IJNRD

View full text Add to dashboard Cite

Abstract:The Model for End-Stage Liver Disease (MELD) score incorporates serum creatinine and was introduced to facilitate allocation of orthotopic liver transplantation (LT). The objective is to determine the impact of MELD and kidney function on all-cause mortality. Among LTs performed in a tertiary referral hospital between 1995 and 2009, 419 cases were studied. Cox proportional hazards models were constructed to estimate the hazard ratios (HR) and 95% confidence intervals (CI) for death. Over mean follow-ups of 8.4 and 3.1 years during the pre-MELD and MELD era, 57 and 63 deaths were observed, respectively. Those transplanted during the MELD era had a higher likelihood of hepatorenal syndrome (8% vs 2%, P , 0.01), lower kidney function (median estimated glomerular filtration rate [eGFR] 77.8 vs 92.6 mL/ min/1.73 m 2 , P , 0.01), and more pretransplantation renal replacement therapy (RRT) (5% vs 1%; P , 0.01). All-cause mortality risk was similar in the MELD vs the pre-MELD era (HR: 0.98, 95% CI: 0.58-1.65). The risk of death, however, was nearly 3-fold greater (95% CI: 1.14-6.60) among those requiring pre-transplant RRT. Similarly, eGFR , 60 mL/min/1.73 m 2 post-transplant was associated with a 2.5-fold higher mortality (95% CI: 1.48-4.11). The study suggests that MELD implementation had no impact on all-cause mortality post-LT. However, the need for pre-transplant RRT and post-transplant kidney dysfunction was associated with a more than 2-fold greater risk of subsequent death.

show abstract

“…The incidence of renal failure after orthotopic liver transplant ranges from 12% to 70%. 10 Several factors should be considered regarding renal dysfunction after liver transplant. 11 Damage from some medicines is one of the major causes of renal dysfunction.…”

Section: Resultsmentioning

confidence: 99%

Untitled

Lin

Chen²,

Lin³

et al. 2017

Exp Clin Transplant

View full text Add to dashboard Cite

Objectives: Preservation of renal function is an important issue after living donor liver transplant. We aimed to examine the renal protective efficacy of telbivudine in hepatitis B virus-infected patients after living donor liver transplant. Materials and Methods:In this retrospective study, we compared 18 patients who received telbivudine 600 mg once per day and 23 patients who received entecavir 1 mg once per day after living donor liver transplant. Clinical data were obtained through chart review and included Model for End-Stage Liver Disease score and pre-and postoperative aspartate aminotransferase, alanine aminotransferase, and creatinine levels and estimated glomerular filtration rate. Results: Posttransplant estimated glomerular filtration rates and creatinine levels were calculated, and improvement of renal function was found in the group of patients who received telbivudine. Significant improvements were shown in estimated glomerular filtration rates started after 9 months of administration and creatinine levels after 12 months compared with patients who received entecavir. Conclusions: In our study, long-term telbivudine therapy is associated with a sustained improvement of renal function in patients with hepatitis B virus infection after living donor liver transplant.

show abstract

Impact of Renal Failure on Liver Transplantation Survival

Cited by 36 publications

References 5 publications

Twenty-Year Longitudinal Follow-Up After Orthotopic Liver Transplantation: A Single-Center Experience of 313 Consecutive Cases

Twenty-Year Longitudinal Follow-Up After Orthotopic Liver Transplantation: A Single-Center Experience of 313 Consecutive Cases

Kidney function and mortality post-liver transplant in the Model for End-Stage Liver Disease era

Untitled

Contact Info

Product

Resources

About