Impact of reconstruction parameters on lesion detection and localization in joint ictal/inter-ictal SPECT reconstruction

Onwanna, Jaruwan; Chantadisai, Maythinee; Tepmongkol, Supatporn; Fahey, Frederic H.; Ouyang, Jinsong; Rakvongthai, Yothin

doi:10.1007/s12149-021-01680-x

Cited by 2 publications

(1 citation statement)

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“…Many other techniques have been recently implemented other than using SISCOM to aid the EZ localization. SPECT reconstruction method that jointly reconstructed ictal and interictal SPECT projection data showed a reduction of noise in the image used for seizure localization than the conventional subtraction method and showed good EZ localization (66,67). Clearance patterns of 99m Tc-ECD are also helpful in evaluating the seizure onset zone in that the seizure onset zone showed slower washout in ictal SPECT but faster washout in interictal SPECT than in contralateral brain regions (68).…”

Section: Brain Perfusion Spectmentioning

confidence: 99%

Nuclear imaging for localization and surgical outcome prediction in epilepsy: A review of latest discoveries and future perspectives

Sukprakun

Tepmongkol

2022

Front. Neurol.

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BackgroundEpilepsy is one of the most common neurological disorders. Approximately, one-third of patients with epilepsy have seizures refractory to antiepileptic drugs and further require surgical removal of the epileptogenic region. In the last decade, there have been many recent developments in radiopharmaceuticals, novel image analysis techniques, and new software for an epileptogenic zone (EZ) localization.ObjectivesRecently, we provided the latest discoveries, current challenges, and future perspectives in the field of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in epilepsy.MethodsWe searched for relevant articles published in MEDLINE and CENTRAL from July 2012 to July 2022. A systematic literature review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis was conducted using the keywords “Epilepsy” and “PET or SPECT.” We included both prospective and retrospective studies. Studies with preclinical subjects or not focusing on EZ localization or surgical outcome prediction using recently developed PET radiopharmaceuticals, novel image analysis techniques, and new software were excluded from the review. The remaining 162 articles were reviewed.ResultsWe first present recent findings and developments in PET radiopharmaceuticals. Second, we present novel image analysis techniques and new software in the last decade for EZ localization. Finally, we summarize the overall findings and discuss future perspectives in the field of PET and SPECT in epilepsy.ConclusionCombining new radiopharmaceutical development, new indications, new techniques, and software improves EZ localization and provides a better understanding of epilepsy. These have proven not to only predict prognosis but also to improve the outcome of epilepsy surgery.

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Section: Brain Perfusion Spectmentioning

confidence: 99%