Impact of Recipient and Donor Nonimmunologic Factors on the Outcome of Deceased Donor Kidney Transplantation

Shaheen, Mohammed F; Shaheen, Faissal A M; Attar, Besher; Elamin, K. M.; Hayyan, H. Al; Sayyari, Abdulla Al

doi:10.1016/j.transproceed.2009.12.052

Cited by 21 publications

(16 citation statements)

References 19 publications

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“…22 These kidneys were refused by 2 transplant centers before finally being accepted by a third. We found that the rate of creatinine clearance at organ recovery did not affect graft or patient survival or final graft function but did influence the frequency of DGF.…”

Section: Scd-optimal Scd-suboptimalmentioning

confidence: 99%

Comparison of Expanded Criteria Kidneys With 2-Tier Standard Criteria Kidneys: Role of Delayed Graft Function in Short-Term Graft Outcome

Fa¹,

Attar²,

Hejaili³

et al. 2012

Exp Clin Transplant

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Objectives: To compare transplant outcomes between expanded criteria donor kidneys and standard criteria donor kidneys. Materials and Methods: All adult renal transplants from deceased donors performed in Saudi Arabia over a 24-month period were included. Donor and recipient factors were recorded, and their effects on outcomes with expanded criteria donor and standard criteria donor kidneys were compared. Standard criteria donor kidneys were further subgrouped into optimal and suboptimal groups, and outcomes were compared. Results: A total of 280 deceased-donor kidney transplants were performed during the study period. Of these, 61 (21.8%) involved expanded criteria donor kidneys. Cold ischemia time and prevalence of delayed graft function were similar between expanded criteria and standard criteria kidneys (P = .7 and P = .8). Graft survival rates at 2 years were also similar (93.3% vs 94.6%; P = .8). Delayed graft function exerted a negative effect on 2-year graft survival in both the expanded group (hazard ratio, 4.9; 95% CI 3.2-7.5; P = .001) and the standard group (hazard ratio, 4.6; 95% CI 3.24-7.5; P = .001). No difference was found between the 2 standard criteria subgroups with respect to serum creatinine value at the end of follow-up (P = .8), delayed graft function prevalence (P =.5), or 2-year graft survival (P = .8). The only independent factor affecting graft survival was delayed graft function (P = .001). No independent effect was seen for expanded criteria donor versus standard criteria donor, donor serum creatinine level, or recipient age. Conclusions: Similar short-term outcomes were found for expanded criteria and standard criteria kidney recipients. Delayed graft function was associated with significant risk of graft loss in both groups, with decreases in 2-year graft survival of 33.3% and 18.3%. No difference was seen between the 2 subtypes of standard criteria donor kidneys.

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Section: Scd-optimal Scd-suboptimalmentioning

confidence: 99%

Comparison of Expanded Criteria Kidneys With 2-Tier Standard Criteria Kidneys: Role of Delayed Graft Function in Short-Term Graft Outcome

Fa¹,

Attar²,

Hejaili³

et al. 2012

Exp Clin Transplant

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“…A study on the influence of nonimmunologic factors on the outcome of extended criteria among deceased donor kidney transplants showed that donor age did not affect graft function or survival, or patient mortality. [5] The complement-dependent lymphocytoxicity with donor peripheral blood lymphocytes as the target is a standard pretransplant test. A positive cross match of more than 50% cell death by cytotoxicity clearly indicates the presence of antibodies to class I antigens.…”

Section: Discussionmentioning

confidence: 99%

Complement-dependent lymphocytotoxicity crossmatch in deceased donor renal transplant: A single institutional experience

Revi

Balapriya

Venkatesh

et al. 2011

Indian Journal of Medical Microbiology

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Complement-dependent lymphocytotoxicity crossmatches (n=217) between 47 deceased donors and 150 potential renal recipients were retrospectively studied. A negative cross match was reported in 48 (22.1%), doubtful positive in 126 (58.1%), weakly positive in 32 (14.7%) and positive in 11 (5.1%). No autoantibodies were detected. Renal transplantation was performed in 35.5% of the potential recipients. There was no incidence of hyperacute rejection. The graft survival rate was 88% at 15 months of follow up. The study concludes that a negative pretransplant lympocytotoxicity crossmatch using the basic National Institute of Health technique eliminates hyperacute rejection, but carries drawbacks, which require modification and supplementation with more sensitive and specific assays.

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“…Cibrik et al 2002;Oppenheimer, Aljama et al 2004); this is partially offset by the reduction in mortality associated with reduced wait-list time. In addition, female-to-male donation, major donor kidney weight/recipient weight inadequacy, cerebrovascular accidents (CVA) as the cause of donor death and the presence of donor comorbidities such as diabetes have an adverse impact on graft and/or patient survival (Feldman, Fazio et al 1996;Giral, Nguyen et al 2005;Ahmad, Cole et al 2009;Shaheen, Shaheen et al 2010). However, utilization of kidneys from deceased donors who had developed acute renal failure prior to organ procurement does not appear to have an unfavorable effect on graft outcome (Deroure, Kamar et al 2010).…”

Section: Deceased Donor Kidney Transplantationmentioning

confidence: 99%

The Impact of Donor Type and Quality on Renal Transplant Outcomes

Nguyen¹,

Yong²,

Croke³

et al. 2011

Understanding the Complexities of Kidney Transplantation

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Impact of Recipient and Donor Nonimmunologic Factors on the Outcome of Deceased Donor Kidney Transplantation

Cited by 21 publications

References 19 publications

Comparison of Expanded Criteria Kidneys With 2-Tier Standard Criteria Kidneys: Role of Delayed Graft Function in Short-Term Graft Outcome

Comparison of Expanded Criteria Kidneys With 2-Tier Standard Criteria Kidneys: Role of Delayed Graft Function in Short-Term Graft Outcome

Complement-dependent lymphocytotoxicity crossmatch in deceased donor renal transplant: A single institutional experience

The Impact of Donor Type and Quality on Renal Transplant Outcomes

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