Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners

Janssens, A. Cecile J.W.; Doorn, P.A. van; Boer, Josien B. de; Meché, F.G.A. van der; Passchier, Jan; Hintzen, Rogier Q.

doi:10.1034/j.1600-0404.2003.00166.x

Cited by 259 publications

(237 citation statements)

References 32 publications

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“…The first four domains are associated with physical health, and the last four, with mental health. The total score ranges from zero (worst) to 100 (best) 11,12 . Kappa statistic was utilized to verify the level of concordance among the instruments.…”

Section: Methodsmentioning

confidence: 99%

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Implications of HAM/TSP functional incapacity in the quality of life

Shublaq

Orsini

Puccioni-Sohler

2011

Arq. Neuro-Psiquiatr.

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Objective: To identify the functional status and quality of life of HAM/TSP patients. Method: We evaluated prospectively 30 HAM/TSP patients (20 females) seen in the Neuroinfection Clinic of the HUGG. The functional capacity was analyzed by the functional independence measure (FIM), the expanded disability status (EDSS) scale and the Osame's motor disability score (OMDS). The quality of life was assed by the Short-Form Health Survey 36 (SF-36) TM . Results: All patients need assistance device. The FIM, OMDS and EDSS scores classified 70%, 67% and 67% of the patients as dependent, respectively. The lowest scores of the SF-36 survey were found in the domains related to the physical health (D1, D2), role-emotional functioning (D7) and social functioning (D6). Conclusion: Our data suggest that the HAM/TSP physical impairment has an impact in the emotional and social issues, considering the limitation in the daily activities. Key words: HAM/TSP, myelopathy, functional capacity, quality of life.Implicações da incapacidade funcional na qualidade de vida de pacientes com HAM/TSP RESUMO Objetivo: Avaliar a capacidade funcional e sua interferência na qualidade de vida de pacientes com HAM/TSP. Método: Foram analisados prospectivamente 30 casos (20 mulheres) de HAM/TSP, atendidos no Ambulatório de Neuroinfecção do HUGG. As escalas para avaliação da capacidade funcional consistiram em: medida de independência funcional (FIM), escala de incapacidade expandida (EDSS) e pontuação da incapacidade motora de Osame (OMDS). A qualidade de vida foi analisada pelo Short-Form 36 Health Survey (SF-36) TM . Resultados: Todos os pacientes necessitavam de assistência para deambular. As escalas FIM, OMDS e EDDS classificaram 70%, 67% e 67% dos pacientes como dependentes, respectivamente. A avaliação pelo SF-36 demonstrou menores escores nos domínios físico (D1, D2), emocional (D7) e social (D6). Conclusão: Os achados sugerem que a limitação nas atividades diárias decorrentes do envolvimento físico comprometem aspectos emocionais e sociais na HAM/TSP. Palavras-chave: HAM/TSP, mielopatia, capacidade funcional, qualidade de vida.

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Section: Methodsmentioning

confidence: 99%

“…The Osame's motor disability score (OMDS) grades the motor dysfunction in relation to the gait disturbance 10 . The medical outcomes study short form-36 health survey (SF-36) is the instrument used to assess quality of life 11,12 . This study identifies the functional status of HAM/ TSP patients through the comparison of functional assessment tools.…”

mentioning

confidence: 99%

Implications of HAM/TSP functional incapacity in the quality of life

Shublaq

Orsini

Puccioni-Sohler

2011

Arq. Neuro-Psiquiatr.

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“…In our study, females with MS reported slightly more symptoms of anxiety than did males (22 There are few robust epidemiological studies addressing anxiety in MS using standardized and validated outcome measures. In addition to their own results, Nicholl et al reviewed past research on emotional problems in people who have MS.…”

Section: Discussionmentioning

confidence: 65%

“…Eight months after diagnosis of MS, 34% of the patients reported that they experienced high levels of anxiety. In a follow-up study two years later, 69% of persons with MS with high anxiety scores at baseline still had high scores [22,23].…”

Section: Discussionmentioning

confidence: 99%

Anxiety and social activities in multiple sclerosis patients

Leonavičius

Adomaitienė

2012

Open Medicine

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AbstractDespite that the prevalence of depression has been thoroughly analyzed in multiple sclerosis (MS) patients and affects approximately 15%–20% of the MS population, attention paid to social activities concomitant with anxiety is still too sporadic. The aim of this study was to find the prevalence of anxiety and social activities aggraded/aggravated with anxiety in the MS population in Lithuania and to analyze how it correlates with socio-demographic factors, clinical outcomes of MS and depression. Three hundred twelve MS patients took part in this study; anxiety prevalence was pointed in 20.2%. Only 23.4% of the study population was socially active. Our study shows a significant level of anxiety and low level of social activity in people with MS. Anxiety in MS patients was strongly related with younger age, shorter MS duration, prevalence of depression and lower level of social activity. A higher level of social activity was significantly related with older urban MS patients who indicated family status as living together and longer MS duration.

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“…Causes of depression and anxiety in this patient population include MS-related processes, genetic and environment-related predisposition, normal grieving and adjustment to loss [10,11]. Although depression and anxiety tend to worsen as physical disability increases [12], psychiatric comorbidities such as depression and anxiety are frequently present at the time of MS diagnosis [2,3,8,13].…”

Section: Introductionmentioning

confidence: 99%

A 12-month prospective, observational study evaluating the impact of disease-modifying treatment on emotional burden in recently-diagnosed multiple sclerosis patients: The POSIDONIA study

Montanari¹,

Rottoli

Maimone

et al. 2016

Journal of the Neurological Sciences

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Introduction: Depression and anxiety are common among patients with multiple sclerosis (MS) and are frequently present at the time of MS diagnosis. Methods: POSIDONIA was a 12-month, observational, prospective study conducted in Italy to evaluate the impact of disease-modifying treatment (DMT) on emotional burden in patients with recently-diagnosed MS. The Hospital Anxiety and Depression Scale (HADS), specifically HADS anxiety (HADS-A) and depression (HADS-D) subscale scores, the Short-Form 36 Health Survey (SF-36) and the Impact of Event Scale -Revised (IES-R) were used to measure patient-reported outcomes. The Hamilton Depression Rating Scale (HDRS), HDRS-17, was used as a measure of healthcare provider-reported outcomes. The primary study outcome was change from baseline in feelings of anxiety and depression over 12 months (via HADS). Results: Of 250 enrolled patients, 222 (88.8%) completed the study. At baseline, mean HADS total, HADS-A and HADS-D subscale scores were within the normal range. There were no significant changes over time in mean HADS total and HADS-A and HADS-D subscale scores, although the subgroup of patients with baseline scores indicative of anxiety or depression tended to improve over time. Both the HDRS and IES-R total scores improved over time, but there were no statistically significant changes in SF-36. Conclusion: In the patient population of the POSIDONIA study depression and anxiety were present in a minority of patients thus not allowing to detect the impact of starting DMT. However DMT appears to have a positive effect in patients with measurable anxiety or depression at baseline.

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Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners

Abstract: Both patients and their partners demonstrated high levels of anxiety and distress in the early period after the diagnosis. These findings indicate careful attention by health care professionals to identify those who may benefit from further psychological support.

Cited by 259 publications

References 32 publications

Implications of HAM/TSP functional incapacity in the quality of life

Implications of HAM/TSP functional incapacity in the quality of life

Anxiety and social activities in multiple sclerosis patients

A 12-month prospective, observational study evaluating the impact of disease-modifying treatment on emotional burden in recently-diagnosed multiple sclerosis patients: The POSIDONIA study

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