Impact of Probiotic Bacteria on Respiratory Allergy Disorders

Jakubczyk, Dominika; Górska, Sabina

doi:10.3389/fmicb.2021.688137

Cited by 15 publications

(12 citation statements)

References 189 publications

(221 reference statements)

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“…Another important aspect requires adequate attention: there is evidence that most probiotics fail the primary prevention of asthma [ 78 , 79 ]. Contrariwise, some convincing studies proved that probiotic supplementation reduced asthma severity in children with pre-existing asthma [ 47 , 48 , 49 ].…”

Section: The Relevance Of Propam Study In Asthma Managementmentioning

confidence: 99%

Probiotics in Children with Asthma

Ciprandi

Tosca

2022

Children

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A type-2 immune response usually sustains wheezing and asthma in children. In addition, dysbiosis of digestive and respiratory tracts is detectable in patients with wheezing and asthma. Probiotics may rebalance immune response, repair dysbiosis, and mitigate airway inflammation. As a result, probiotics may prevent asthma and wheezing relapse. There is evidence that some probiotic strains may improve asthma outcomes in children. In this context, the PROPAM study provided evidence that two specific strains significantly prevented asthma exacerbations and wheezing episodes. Therefore, oral probiotics could be used as add-on asthma therapy in managing children with asthma, but the choice should be based on documented evidence.

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Section: The Relevance Of Propam Study In Asthma Managementmentioning

confidence: 99%

Probiotics in Children with Asthma

Ciprandi

Tosca

2022

Children

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“…For instance, improved knowledge about the interaction between the gastrointestinal and respiratory microbiomes could serve as a foundational understanding and guide the application of oral probiotics as a treatment potential in the management of allergic disorders of the respiratory tract. 5 , 30 Similarly, a thorough understanding of how cow’s milk formula and cesarean section births result in dysbiosis and increase susceptibility to allergy and asthma development can serve as a scientific rationale for advocating for breast feeding and natural births to reduce the risk of the development of allergic diseases later in life. 31 , 32 Collectively, these examples demonstrate the important need to further develop continuing medical education curricula to include the most updated information about the role of the microbiome in disease pathogenesis as well as potential therapeutic applications to prevent the development and/or mitigate symptoms of diseases of public health importance in Saudi Arabia, such as allergies and asthma.…”

Section: Discussionmentioning

confidence: 99%

Physicians’ Understanding of the Role of the Microbiome in Allergies and Asthma: A Questionnaire-Based Study in Saudi Arabia

AlKhater¹

2022

JAA

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Purpose Allergies and asthma are two noncommunicable illnesses of increasing public health concern in Saudi Arabia. Nevertheless, little is known about knowledge of the microbiome and its relationship to asthma and allergy risks among healthcare professionals, such as pediatricians and family medicine practitioners, who are often involved in the care of patients suffering from these illnesses. Therefore, this study aimed to examine knowledge about microbiome science in these healthcare workers in the eastern region of the kingdom, where allergies and asthma are highly prevalent. Patients and Methods The study survey consisted of 37 online questions in three topical domains, including microbiome science, dysbiosis, and probiotics, and was distributed to 203 participants in various demographic groups. Results The survey analysis revealed that the mean knowledge score was 67.6%. The component scores were highest for the microbiome (75.6%) and lowest for dysbiosis (52.6%). Only 17.7% of the healthcare workers were prescribing probiotic food or drinks for most of their patients with allergies and/or asthma; and 37.8% of the healthcare workers were unaware of the reasons for prescribing pro-/prebiotics. Regression analysis revealed that older age (>45 years old), probiotic prescription experience, and positive beliefs about the importance of nutritional advice were independent predictors of higher microbiome knowledge. Conclusion The analysis not only revealed existing gaps in microbiome knowledge among the participants, including those related to the role of the microbiome in allergy and asthma development but also identified predictors of higher microbiome knowledge. These observations provide an impetus for the rational design of continuing medical education curriculum and training to update healthcare professionals with emerging clinical application of microbiome knowledge for the management of microbiome-related illnesses.

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“…The term “respiratory allergy” is an umbrella term describing a group of upper and lower airway diseases due to chronic exposure to allergens [ 45 ].…”

Section: Inflammation In Allergic Rhinitis: Role Of Microbiotamentioning

confidence: 99%

“…SCFAs are also able to generate an extrathymic peripheral Treg cell pool, linked to dampening allergic airway diseases. However, airway bacteria do not produce SCFAs in substantial amounts, likely due to the absence of substrates [ 45 ].…”

Section: Inflammation In Allergic Rhinitis: Role Of Microbiotamentioning

confidence: 99%

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(R)Evolution in Allergic Rhinitis Add-On Therapy: From Probiotics to Postbiotics and Parabiotics

Capponi

Gori

Castro

et al. 2022

JCM

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Starting from the “Hygiene Hypothesis” to the “Microflora hypothesis” we provided an overview of the symbiotic and dynamic equilibrium between microbiota and the immune system, focusing on the role of dysbiosis in atopic march, particularly on allergic rhinitis. The advent of deep sequencing technologies and metabolomics allowed us to better characterize the microbiota diversity between individuals and body sites. Each body site, with its own specific environmental niches, shapes the microbiota conditioning colonization and its metabolic functionalities. The analysis of the metabolic pathways provides a mechanistic explanation of the remote mode of communication with systems, organs, and microflora of other body sites, including the ecosystem of the upper respiratory tract. This axis may have a role in the development of respiratory allergic disease. Notably, the microbiota is significant in the development and maintenance of barrier function; influences hematopoiesis and innate immunity; and shows its critical roles in Th1, Th2, and Treg production, which are necessary to maintain immunological balance and promote tolerance, taking part in every single step of the inflammatory cascade. These are microbial biotherapy foundations, starting from probiotics up to postbiotics and parabiotics, in a still-ongoing process. When considering the various determinants that can shape microbiota, there are several factors to consider: genetic factors, environment, mode of delivery, exposure to antibiotics, and other allergy-unrelated diseases. These factors hinder the engraftment of probiotic strains but may be upgradable with postbiotic and parabiotic administration directly on molecular targets. Supplementation with postbiotics and parabiotics could represent a very exciting perspective of treatment, bypassing probiotic limitations. At present, this avenue remains theoretical and to be explored, but it will certainly be a fascinating path to follow.

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Impact of Probiotic Bacteria on Respiratory Allergy Disorders

Cited by 15 publications

References 189 publications

Probiotics in Children with Asthma

Probiotics in Children with Asthma

Physicians’ Understanding of the Role of the Microbiome in Allergies and Asthma: A Questionnaire-Based Study in Saudi Arabia

(R)Evolution in Allergic Rhinitis Add-On Therapy: From Probiotics to Postbiotics and Parabiotics

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