“…The majority of the 9,502 respondents were aged 45 years and above (61.5%), were female (52.8%), and were living with a spouse (83.9%) ( Genetic influences [59,60], ACEs [1, 6-8, 56, 61], environmental exposures, and ongoing stress are factors that combine to determine how an individual responds to stress, as well as their vulnerability to psychopathology in adulthood [11,51,62]. Accordingly, it is important to determine whether the mediated effect (indirect effect) is due to dissatisfaction with friendships or some other unmeasured or unaccounted-for variable [5,6].…”