Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility

Zhang, Yuening; Li, Muyan; Xiao, Fei; Teng, Ruobing; Zhang, Chengdong; Lan, Aihua; Gu, Kailong; Li, Jiatong; Wang, Di; Li, Hongtao; Jiang, Li; Zeng, Siping; He, Min; Huang, Yi; Guo, Ping; Zhang, Xinhua; Yang, Xiaoli

doi:10.1016/j.gene.2015.07.083

Cited by 10 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Male infertility is a complex multifactorial disease, and in approximately half of the cases the aetiology is unknown (Krausz et al, 2015). It is widely believed that genetic factors may play an important role in male infertility (Sen et al, 2016;Yarosh et al, 2014;Zhang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Impact of CAG repeat length in the androgen receptor gene on male infertility – a meta-analysis

Xiao

Lan

Lin

et al. 2016

Reproductive BioMedicine Online

Self Cite

View full text Add to dashboard Cite

CAG repeats are polymorphic nucleotide repeats present in the androgen receptor gene. Many studies have estimated the association between CAG repeat length and male infertility, but the conclusions are controversial. Previous meta-analyses have come to different conclusions; however, new studies have been published. An updated meta-analysis was conducted. PubMed, CBM, CNKI and Web of Science databases were systematically searched for studies published from 1 January 2000 to 1 October 2015. Case-control studies on the association between CAG repeat length and male infertility using appropriate methodology were included. Forty studies were selected, including 3858 cases and 3161 controls. Results showed statistically significantly longer CAG repeat length among cases compared with controls (SMD = 0.14; 95% CI, 0.02-0.26). Shorter repeat length was associated with a lower risk of male infertility compared with a longer repeat length in the overall analysis (OR = 0.79, 95% CI: 0.66-0.95). Moreover, CAG repeat length was associated with male infertility in Caucasian populations, but not Asian or Egyptian populations. Subgroup analysis revealed no significant difference in German populations, but CAG repeat length was associated with male infertility in China and the USA. There were no significant differences between cases and controls in azoospermia and severe oligozoospermia.

show abstract

Section: Introductionmentioning

confidence: 99%

Impact of CAG repeat length in the androgen receptor gene on male infertility – a meta-analysis

Xiao

Lan

Lin

et al. 2016

Reproductive BioMedicine Online

Self Cite

View full text Add to dashboard Cite

show abstract

“…By convention, an observed OR > 1 was taken to imply a better pregnancy outcome in the atosiban group, and a corresponding 95%CI for the pooled OR that did not overlap 1 was considered to be statistically significant [19]. We judged heterogeneity by calculating the I 2 statistic, with I 2 ranges from 0–25% indicating low, 25–50% indicating moderate, and 50% indicating high heterogeneity [20]. When I 2 < 50%, a fixed effects model was selected, whereas a random effects model was used when I 2 > 50%.…”

Section: Methodsmentioning

confidence: 99%

The impact of atosiban on pregnancy outcomes in women undergoing in vitro fertilization-embryo transfer: A meta-analysis

et al. 2017

View full text Add to dashboard Cite

BackgroundAtosiban is administered to women undergoing in vitro fertilization-embryo transfer (IVF-ET) to improve pregnancy outcomes. However, the results of this treatment were controversial. We conducted this meta-analysis to investigate whether atosiban improves pregnancy outcomes in the women undergoing in vitro fertilization (IVF).MethodsDatabases of PubMed, EMBASE, Web of Science, China BioMedicine, and Google Scholar were systematically searched. Meta-analyses were performed to investigate whether atosiban improves pregnancy outcomes in the women undergoing IVF.ResultsOur results showed that atosiban was associated with higher implantation (OR = 1.63, 95% CI: 1.17–2.27; P = 0.004) and clinical pregnancy (OR = 1.84, 95% CI: 1.31–2.57; P < 0.001) rates. However, atosiban showed no significant association with the miscarriage, live birth, multiple pregnancy or ectopic pregnancy rates. When a further subgroup analysis was performed in the women undergoing repeated implantation failure (RIF), implantation (OR = 1.93, 95% CI: 1.45–2.57; P < 0.001), clinical pregnancy (OR = 2.48, 95% CI: 1.70–3.64; P <0.001) and the live birth (OR = 2.89, 95% CI: 1.78–4.67; P < 0.001) rates were significantly higher in the case group. Nevertheless, no significant difference was detected in the miscarriage and multiple pregnancy rates between the case and control groups.ConclusionAtosiban may be more appropriate for women undergoing RIF and play only a limited role in improving pregnancy outcomes in the general population of women undergoing IVF. These conclusions should be verified in large and well-designed studies.

show abstract

“…The statistical heterogeneity assumption was evaluated using I 2 statistics to quantify any inconsistency arising from inter-research variability that was derived from heterogeneity instead of random chance [ 107 ]. An I 2 value from 0-25% indicates low heterogeneity, 25-50% moderate heterogeneity and ≥50% high heterogeneity [ 122 ]. Two models (fixed-effect model and random-effect model) were used for analysis [ 123 ].…”

Section: Methodsmentioning

confidence: 99%

Association between the ERCC2 Asp312Asn polymorphism and risk of cancer

Xiao

Wen

et al. 2017

Oncotarget

Self Cite

View full text Add to dashboard Cite

Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries. The relationship between genetic polymorphisms and the risk of cancers has been widely researched. Excision repair cross-complementing group 2 (ERCC2) gene plays important roles in the nucleotide excision repair pathway. There is contrasting evidence on the association between the ERCC2 Asp312Asn polymorphism and the risk of cancer. We conducted a comprehensive meta-analysis in order to assess the correlation between these factors. We searched the PubMed, EMBASE, Science Direct, Web of Science, and CNKI databases for studies published from January 1, 2005 to January 1, 2016. Finally, 86 articles with 38,848 cases and 48,928 controls were included in the analysis. The overall analysis suggested a significant association between the ERCC2 Asp312Asn polymorphism and cancer risk. Furthermore, control source, ethnicity, genotyping method, and cancer type were used for subgroup analysis. The result of a trial sequential analysis indicated that the cumulative evidence is adequate; hence, further trials were unnecessary in the overall analysis for homozygote comparison. In summary, our results suggested that ERCC2 Asp312Asn polymorphism is associated with increased cancer risk. A significantly increased cancer risk was observed in Asian populations, but not in Caucasian populations. Furthermore, the ERCC2 Asp312Asn polymorphism is associated with bladder, esophageal, and gastric cancers, but not with breast, head and neck, lung, prostate, and skin cancers, and non-Hodgkin lymphoma. Further multi-center, well-designed studies are required to validate our results.

show abstract

Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility

Cited by 10 publications

References 23 publications

Impact of CAG repeat length in the androgen receptor gene on male infertility – a meta-analysis

Impact of CAG repeat length in the androgen receptor gene on male infertility – a meta-analysis

The impact of atosiban on pregnancy outcomes in women undergoing in vitro fertilization-embryo transfer: A meta-analysis

Association between the ERCC2 Asp312Asn polymorphism and risk of cancer

Contact Info

Product

Resources

About